Author: Celia Mary Bisbach
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Photoreceptors require an excessive amount of energy to carry out their function, yet their access to the nutrients and oxygen which could facilitate efficient ATP production is restricted by neighboring retinal pigment epithelial (RPE) cells. This dissertation investigates the metabolic adaptations made by both photoreceptors and RPE which allow both cell types to coexist in a competitive environment, with a focus on understanding the independent influences of mitochondrial Ca2+ uptake and O2 tension. Highly specialized photoreceptors in the retina use Ca2+ as a second messenger to transduce light to a chemical signal, yet we find that mitochondrial Ca2+uptake mediated by the Mitochondrial Ca2+ Uniporter is quite dispensable for photoreceptor metabolism and function. Instead, we find that photoreceptor metabolism appears to be programmed by the basal hypoxic niche they normally reside in, which causes photoreceptors produce succinate by non-canonical reversal of succinate dehydrogenase. This succinate is exported from retinas by Monocarboxylate Transporter 1 (MCT1) and is capable of being imported and oxidized by eyecup tissue, which has ample access to O2 in the eye. Transport of succinate between tissues may be more widespread than previously thought, as we also uncover evidence that succinate can be oxidized in cerebellum, kidney, liver, and brown adipose tissue.
Influences of Calcium and Oxygen on Retinal Metabolism
Research Awards Index
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1196
Book Description
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1196
Book Description
Retina E-Book
Author: Charles P. Wilkinson
Publisher: Elsevier Health Sciences
ISBN: 1455737801
Category : Medical
Languages : en
Pages : 2498
Book Description
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
Publisher: Elsevier Health Sciences
ISBN: 1455737801
Category : Medical
Languages : en
Pages : 2498
Book Description
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
Retina
Author: David R. Hinton
Publisher: Elsevier Health Sciences
ISBN: 1455707376
Category : Medical
Languages : en
Pages : 2498
Book Description
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
Publisher: Elsevier Health Sciences
ISBN: 1455707376
Category : Medical
Languages : en
Pages : 2498
Book Description
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
Webvision
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Research Grants Index
Author: National Institutes of Health (U.S.). Division of Research Grants
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1212
Book Description
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1212
Book Description
Toxicity Bibliography
Author:
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 834
Book Description
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 834
Book Description
Diabetes Literature Index
Author:
Publisher:
ISBN:
Category : Diabetes
Languages : en
Pages : 1264
Book Description
Publisher:
ISBN:
Category : Diabetes
Languages : en
Pages : 1264
Book Description
Nuclear Science Abstracts
Author:
Publisher:
ISBN:
Category : Nuclear energy
Languages : en
Pages : 1132
Book Description
Publisher:
ISBN:
Category : Nuclear energy
Languages : en
Pages : 1132
Book Description
Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute
Author: National Heart, Lung, and Blood Institute
Publisher:
ISBN:
Category : Cardiovascular system
Languages : en
Pages : 486
Book Description
Publisher:
ISBN:
Category : Cardiovascular system
Languages : en
Pages : 486
Book Description