Inflammation and Pregnancy PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Inflammation and Pregnancy PDF full book. Access full book title Inflammation and Pregnancy by Donald M. Peebles. Download full books in PDF and EPUB format.
Author: Donald M. Peebles
Publisher: CRC Press
ISBN: 9781842142721
Category : Medical
Languages : en
Pages : 224
Get Book Here
Book Description
Nowhere is the complex relation between inflammation and disease more apparent than in pregnancy. From the immune adaptation necessary for a mother to tolerate a genetically different fetus through gestation, to the role of inflammatory mediators in abnormalities of pregnancy such as pre-eclampsia and premature delivery, it is clear that inflammation plays a vital role in determining pregnancy outcome. In this authoritative text, an international panel of prestigious authors explores the complex relationship between inflammation, the mother, placenta and fetus. Providing comprehensive coverage by discussing both basic sciences and clinical applications, the book also ensures wide appeal by presenting a synthesis of the maternal and fetal aspects of immunological disorders in pregnancy. The only recent work on the subject in this fast-moving field, Inflammation and Pregnancy is relevant to a wide range of scientists and clinicians with an interest in inflammation, early pregnancy, placental development, pre-eclampsia, pre-term delivery and fetal/neonatal development.
Author: Donald M. Peebles
Publisher: CRC Press
ISBN: 9781842142721
Category : Medical
Languages : en
Pages : 224
Get Book Here
Book Description
Nowhere is the complex relation between inflammation and disease more apparent than in pregnancy. From the immune adaptation necessary for a mother to tolerate a genetically different fetus through gestation, to the role of inflammatory mediators in abnormalities of pregnancy such as pre-eclampsia and premature delivery, it is clear that inflammation plays a vital role in determining pregnancy outcome. In this authoritative text, an international panel of prestigious authors explores the complex relationship between inflammation, the mother, placenta and fetus. Providing comprehensive coverage by discussing both basic sciences and clinical applications, the book also ensures wide appeal by presenting a synthesis of the maternal and fetal aspects of immunological disorders in pregnancy. The only recent work on the subject in this fast-moving field, Inflammation and Pregnancy is relevant to a wide range of scientists and clinicians with an interest in inflammation, early pregnancy, placental development, pre-eclampsia, pre-term delivery and fetal/neonatal development.
Author: Peter Perlmann
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805573766
Category : Medical
Languages : en
Pages : 422
Get Book Here
Book Description
Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Author: Kathryn B.H. Clancy
Publisher: Springer Science & Business Media
ISBN: 1461440602
Category : Science
Languages : en
Pages : 527
Get Book Here
Book Description
The ontogeny of each individual contributes to the physical, physiological, cognitive, neurobiological, and behavioral capacity to manage the complex social relationships and diverse foraging tasks that characterize the primate order. For these reasons Building Babies explores the dynamic multigenerational processes of primate development. The book is organized thematically along the developmental trajectory:conception, pregnancy, lactation, the mother-infant dyad, broader social relationships, and transitions to independence. In this volume, the authors showcase the myriad approaches to understanding primate developmental trajectories from both proximate and ultimate perspectives. These collected chapters provide insights from experimental manipulations in captive settings to long-term observations of wild-living populations and consider levels of analysis from molecule to organism to social group to taxon. Strepsirrhines, New World monkeys, Old World monkeys, apes, and humans are all well-represented. Contributions by anthropologists, microbiologists, psychologists, population geneticists, and other primate experts provide Building Babies a uniquely diverse voice. Building Babies features multi- and trans-disciplinary research approaches to primate developmental trajectories and is particularly useful for researchers and instructors in anthropology, animal behavior, psychology, and evolutionary biology. This book also serves as a supplement to upper-level undergraduate courses or graduate seminars on primate life history and development. In these contexts, the book provides exposure to a wide range of methodological and theoretical perspectives on developmental trajectories and models how researchers might productively integrate such approaches into their own work.
Author: Anthony Carter
Publisher: Boydell & Brewer
ISBN: 9781580460439
Category : Maternal-fetal exchange
Languages : en
Pages : 456
Get Book Here
Book Description
The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
Author: Laura Howe
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Gil Mor
Publisher: Springer Science & Business Media
ISBN: 0387349448
Category : Medical
Languages : en
Pages : 338
Get Book Here
Book Description
This book covers in detail contemporary hypotheses and studies related to the immunology of implantation and provides a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR. Provides complete and up to date review of current knowledge of the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system.
Author: Uri Elkayam
Publisher: John Wiley & Sons
ISBN: 1119409829
Category : Medical
Languages : en
Pages : 1227
Get Book Here
Book Description
Cardiac Problems in Pregnancy offers clinicians the most detailed and comprehensive guide to diagnosing and managing pregnancy-associated cardiovascular diseases currently available. Covering a wide spectrum of congenital and acquired cardiovascular conditions, its extensive contents examine diseases of the heart with an expert awareness of the implications of pregnancy and the attendant physiological changes it brings. Such guidance is vitally required in an age in which congenital and acquired heart diseases are the leading causes of non-obstetrical maternal morbidity and mortality. Featuring 36 new or extensively revised chapters, this fourth edition of the book complements coverage of the latest research and clinical advances with a complete and up-to-date bibliography of literature on pregnancy in women with cardiovascular conditions. It also serves as a practical, step-by-step companion for those caring for heart disease patients during pregnancy, labor, and the post-partum period. Contents include: Coverage of all elements of maternal cardiology Newly written chapters featuring fresh research and data Guidance on performing risk assessments and interventions both prior to and during gestation Explanations of a range of diagnostic and therapeutic approaches to cardiovascular disease in pregnant patients Drawing on expertise from across the fields of cardiovascular medicine, obstetrics, anesthesiology, cardiac surgery, pharmacology, and clinical science, Cardiac Problems in Pregnancy is designed to give invaluable support to all medical professionals involved in maximizing the safety and success of cardiologically complex pregnancies.
Author: Sandra Hellberg
Publisher: Linköping University Electronic Press
ISBN: 9179299938
Category :
Languages : en
Pages : 118
Get Book Here
Book Description
Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
Author: Alfred B. Kurtz
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 320
Get Book Here
Book Description
This manual provides radiologists, diagnostic radiologists and gastroenterologists with an organ-by-organ approach to the subject in relation to ultrasound scanning. It includes coverage of the liver disease, the spleen, pancreas, gastrointestinal tract and biliary system.
Author: Adel Elkady
Publisher: Cambridge University Press
ISBN: 1108716636
Category : Medical
Languages : en
Pages : 215
Get Book Here
Book Description
Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.
