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Author: Paul G. Winyard
Publisher: Springer Science & Business Media
ISBN: 1592593747
Category : Medical
Languages : en
Pages : 373
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Book Description
Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter’s words in 1795, “inflammation is a salutary response.” That may be applied in particular to the defensive response to invading micro- ganisms.
Author: Paul G. Winyard
Publisher: Springer Science & Business Media
ISBN: 1592593747
Category : Medical
Languages : en
Pages : 373
Get Book Here
Book Description
Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter’s words in 1795, “inflammation is a salutary response.” That may be applied in particular to the defensive response to invading micro- ganisms.
Author: Jean-Marc Cavaillon
Publisher: John Wiley & Sons
ISBN: 3527338993
Category : Medical
Languages : en
Pages : 1818
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Book Description
Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128094273
Category : Medical
Languages : en
Pages : 431
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Book Description
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Author: Schook
Publisher: Academic Press
ISBN: 032314036X
Category : Medical
Languages : en
Pages : 384
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Book Description
The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.
Author:
Publisher: Academic Press
ISBN: 9780123812834
Category : Science
Languages : en
Pages : 408
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Book Description
Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128121475
Category : Medical
Languages : en
Pages : 624
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Book Description
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating 'toxic assets' and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. - Presents the most advanced information regarding the role of the autophagic system in life and death - States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities - Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease - Authored by global leaders in the field, bringing the broadest, most expert coverage available
Author: Undurti N. Das
Publisher: Springer Science & Business Media
ISBN: 940070495X
Category : Medical
Languages : en
Pages : 591
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Book Description
The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
Author: Alex Vasquez
Publisher: Createspace Independent Publishing Platform
ISBN: 9781530527113
Category :
Languages : en
Pages : 474
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Book Description
Refinements/edits made to text 20 Apr 2016: This work is the culmination of several thousand research publications combined with Dr Vasquez's many years of clinical experience and teaching graduate/doctorate-level students and clinicians worldwide. With radiographs, photos, acronyms, illustrations, flowcharts, and detailed-yet-simplifying explanations, Dr Vasquez makes it easier than ever for clinicians to grasp important concepts in integrative care and functional medicine and then translate the basic science and molecular biology into treatment plans that can be explained and used in "the real world" of clinical practice.This second volume is written for clinicians already conversant in Ch.1) Patient assessment, laboratory interpretation, risk management, hypothyroidism, hemochromatosis, Ch.2) Wellness, Personalized Lifestyle Medicine, Ch.3) Integrative pain management using nutrition, botanicals, and manipulative medicine, Ch.4) Functional Inflammology Protocol: Diet, Polydysbiosis/Infections, Viral infections, Nutritional immunomodulation, Mitochondrial dysfunction, mTOR, ERS-UPR, Orthoendocrinology, Xenobiotic detoxification.Contents: updated Chapter 5 from "Inflammation Mastery, 4th Ed"1) Hypertension...727, 2) Diabetes Mellitus...819, 3) Migraine & Headaches...863, 4) Fibromyalgia...901, 5) Allergic Inflammation...984, 6) Rheumatoid Arthritis...1019, 7) Psoriasis & Psoriatic Arthritis...1038, 8) Systemic Lupus Erythematosus...1053, 9) Scleroderma & Systemic Sclerosis...1074, 10) Vasculitic Diseases...1094, 11) Spondyloarthropathies & Reactive Arthritis...1108, 12) Sjögren Disease...1119, 13) Raynaud's Disorder...1127, 14) Clinical Notes on Behçet's Disease, Sarcoidosis, Dermatomyositis & Polymyositis...1131. The associated video tutorials and recorded live conference presentations further help students and clinicians "get it" via Dr Vasquez's effective teaching style which embraces complexity while always emphasizing clinical applicability and psychosocial context. The Inflammation Mastery & Functional Inflammology series of books and videos translates important concepts and nutritional/biomedical science into easy and practical clinical applications for the prevention and treatment of disorders of sustained inflammation, which Dr Vasquez describes as "patterns of metabolic disturbance and inflammatory dysfunction" existing in three sequential and overlapping categories: 1) metabolic inflammation, 2) allergic inflammation, 3) autoimmune inflammation. This book includes access to video presentations which introduce the origin and components of the Functional Inflammology Protocol and FINDSEX(r) acronym. Post-publication updates to this information and important social and clinical contextualization are made available in videos and online repositories (access provided in the book), and the e-newsletter available from ICHNFM.ORG. This textbook also provides access, via reprints or hyperlinks, to Dr Vasquez's published articles-paradigm-shifting perspectives published in Alternative Therapies in Health and Medicine (2004, 2014) and Nature Reviews Rheumatology (2016). Updated section on pain management allows students and clinicians to understand and apply manual, pharmacologic, nutritional/botanical medicine treatments for musculoskeletal pain, thereby providing better relief for patients and avoiding the hazards of NSAIDs, coxibs, steroids, opioids, immunosuppressants and biologics. Discounted grayscale printing; for full-color see ISBN 0990620441. The most recent publication from ICHNFM.ORG is "Functional Medicine Clinical Protocols for Inflammatory Disorders: Functional Inflammology, Vol 2" (2016; printed in color via ISBN 0990620441), which extends Vol 1 printed in 2014 in color as "Functional Inflammology" (ISBN 0990620409) and grayscale as "Inflammation Mastery" (ISBN 1500545945); also updated and published in color in 2016 as a single volume as "Inflammation Mastery, 4th Ed" (ISBN 0990620484).
Author: Christopher E. M. Griffiths
Publisher: John Wiley & Sons
ISBN: 1118441192
Category : Medical
Languages : en
Pages : 1051
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Book Description
Die 9. Auflage von Rook's Textbook of Dermatology steht für: - die Nummer 1 im Bereich der Dermatologie mit allem Wissenswerten zu dem Fachgebiet - ein unverzichtbares Referenzwerk für alle Dermatologen. - ein herausragendes Nachschlagewerk, das als Printausgabe und E-Book erhältlich ist und alle Krankheitsbilder in der Dermatologie umfassend abdeckt. - eine vollständig überarbeitete Auflage, in der jede Erkrankung in einem einheitlichen Format präsentiert wird. - einen neuen Ansatz bei der Klassifizierung von Erkrankungen: Die Zahl der Kapitel wurde verdoppelt (jetzt 160 statt vormals 80 Kapitel). Alle Kapitel sind nach logischen Abschnitten organisiert, mit einem komplett neuen Inhaltsverzeichnis. - schnelle, leistungsstarke und weitreichende Suchfunktionen bei der digitalen Ausgabe mit der Möglichkeit, online nach Krankheitsbildern, Kapiteln oder Abbildungen zu suchen. Ratschläge von Experten aus der klinischen Praxis sind jetzt schneller verfügbar. - aufwendig illustrierte Kapitel mit über 3000 farbigen Abbildungen, die Abweichungen von Krankheitsmustern nach Körperteil, Hauttyp und Schweregrad zeigen. - umfassende Informationen aus der medizinischen, plastischen und kosmetischen Dermatologie sowie wissenschaftliche Grundlagen. - ein renommiertes Herausgeber- und Autorenteam von Weltklasse. - eine stärkere Gewichtung bei klinischen Studien/Erprobungen, Richtlinien von Gesellschaften und den neuesten ICD-Codes. - Schlüsselreferenzen in der Printausgabe und Hunderten von zusätzlichen Online-Referenzen mit Hyperlinks. Die 9. Auflage von Rook's Textbook of Dermatology ist das Nachschlagewerk in der Dermatologie. Die Publikation ist jetzt noch umfassender, enthält mehr Abbildungen, präsentiert mehr Krankheitsbilder, bietet schnellere, dynamischere und ausführlichere digitale Suchfunktionen. Dieses Referenzwerk ist ein Muss für heutige Dermatologen, ob erfahrener Praktiker oder Berufsanfänger.
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
