Author: Willoughby
Publisher: Springer
ISBN: 3034887477
Category : Medical
Languages : en
Pages : 232
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Book Description
This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con flicting statements in a number of the chapters. We believe that this is entirely appro priate as this volume reflects the latest work in a rapidly developing area.
Author: Vito Turk
Publisher: Birkhäuser
ISBN: 303488737X
Category : Science
Languages : en
Pages : 238
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Book Description
This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.
Author: Jens-Michael Schröder
Publisher: Springer Science & Business Media
ISBN: 9783764358471
Category : Medical
Languages : en
Pages : 198
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Book Description
This book combines the two major functions of fatty acids in skin biol ogy. Fatty acids play an important role in the barrier function of ski n and represent a major source of proinflammatory mediators such as pr ostaglandins, leukotrienes and other lipids in inflammatory skin disor ders (e.g. proinflammatory eicosanoids which play a role in psoriasis and a topic dermatitis). The pharmacological inhibition of eicosanoid biosynthesis is also reviewed.
Author: S.D. Brain
Publisher: Springer
ISBN: 3034887531
Category : Medical
Languages : en
Pages : 355
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Book Description
This volume is intended to bring together recent advances in the often separate fields of pain and neurogenic inflammation. To this end, eminent researchers from both domains have contributed in-depth discussion of the mechanisms underlying these processes. Individual chapters focus on important recent discoveries such as the cloning of the capsaicin receptor and the discovery of RAMP proteins for CGRP receptors. This book provides an integrated account of recent advances in the fields of pain and neurogenic inflammation. The volume is intended to bring together studies from eminent researchers in the often separate research fields of pain and inflammation. "Pain and Neurogenic Inflammation" is aimed primarily at postgraduate researchers as well as academic and industrial researchers in pain and inflammation but is also likely to be of interest to undergraduate students seeking a firm grounding in the mechanisms underlying these important clinical conditions.
Author: D. A. Willoughby
Publisher: Birkhauser
ISBN: 9780817658502
Category : Cyclooxygenases
Languages : en
Pages : 211
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Book Description
The book brings together overviews by leading researchers in the field of the current status of knowledge of COX, NOS and HO in inflammation. These overviews cover a series of new concepts in the mechanism of inflammation. Topics include inducible enzyme involvement in inflammatory processes including the role in vascular permeability, leukocyte migration, granuloma formation, angiogenesis, neuroinflammation and algesia. New findings from transgenic animal models are reviewed. Other chapters address the importance of these enzymes in inflammatory disease states including rheumatoid arthritis, atherosclerosis and multiple sclerosis. The possibility of selective inhibitors or inducers of COX, NOS and HO, and their use in the clinic is discussed. The subject matter of this book is of interest to rheumatologists, pathologists, pharmacologists, neuroscientists and anyone with an academic interest in the mechanisms of inflammation.
Author: L.R. Watkins
Publisher: Springer Science & Business Media
ISBN: 9783764358495
Category : Medical
Languages : en
Pages : 248
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Book Description
The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
Author: Wagner
Publisher: Birkhäuser
ISBN: 3034887639
Category : Medical
Languages : en
Pages : 390
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Book Description
The human immune system, despite having its own sophisticated defence mecha nisms, is inferior to bacteria and viruses with respect to adaptability. Furthermore, our immune system is increasingly exposed to detrimental effects, that is immuno suppressive environmental consequences, unhealthy living, and chronic illnesses. Excessive chemotherapy threatens our immune system even further. This situation demands compensatory prophylactic therapeutic regimes. One of these - specific immunostimulation - is more difficult to achieve than the immunosuppression cur rently used in transplantation surgery and the medical treatment of autoimmune dis eases. The earliest attempts to develop suitable medication for immunostimulation were based on traditional remedies which embodied the accumulated experience of several centuries. Medicinal plants are already being used prophylactically as stan dardized and efficacy-optimized preparations for the treatment of various recur rent infections, or in combination with chemotherapeutics in standard medical practice. In order to rationally apply immunostimulants of plant origin, however, it is necessary to search for the active principles of these substances and to produce them in a pure form. Because suitable screening methods have become available only recently, research in this field is in its very beginning. Further progress can be expected from systematic basic research on the mechanisms underlying immunomodulation. This also applies to verification of clinical efficacy, which is a prerequisite for the acceptance of medications with purported immunostimulatory properties.
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author: Ernst van Faassen
Publisher: Elsevier
ISBN: 0080489591
Category : Science
Languages : en
Pages : 444
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Book Description
Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. - First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes - Extensive bibliographic references, written by specialists of human physiology - Providing high scientific quality with a focus on implications for human diseases
Author:
Publisher: Academic Press
ISBN: 0080536379
Category : Science
Languages : en
Pages : 375
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Book Description
Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. - Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques - Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression - Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone - Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution
