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Languages : en
Pages :
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Languages : en
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Author: Srinandini Parthasarathy
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
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Humans spend most of their time indoors, in residences and commercial buildings. In this thesis, I evaluate exposures to volatile (VOCs) and semivolatile organic compounds (SVOCs) in indoor environments. I use a combination of literature review and evaluation, mechanistic modeling, and skin-wipe collection and analysis to develop an understanding of the role of indoor air as an exposure medium for inhalation and passive dermal uptake of pollutants. This dissertation explores three related research topics on indoor environments and human exposures. In Chapter 2, I conduct a comprehensive review of reported measurements of pollutants found in commercial buildings. I used the literature review to estimate concentration ranges that can be compared to health-based exposure limits as basis for hazard assessment. I use the regulatory exposure limits set by government agencies to calculate hazard indices as the ratio of observed concentrations to regulatory standards. I also compare the odor and pungency thresholds of individual pollutants to observed concentrations to evaluate their potential to exceed odor thresholds. The hazard evaluation identifies the potential for health impacts at concentrations commonly found in commercial buildings. This analysis focuses exclusively on VOCs and SVOCs in commercial buildings and identified a limited set of pollutants that pose health concerns. I also characterize the selected pollutants in terms of the chemical properties that,affect partitioning to various indoor surfaces, and subsequently their fate and transport in indoor environments. Based on chemical properties and indoor fate, I grouped the pollutants into five groups. I use an hierarchical k-means analysis based on octanol-air partitioning coefficient, octanol-water partitioning coefficient, air-water partitioning coefficient, and molecular weight. The pollutants in each group are expected to behave similarly in indoor environments. In Chapter 3, I evaluate the role of buildings operation parameters such as ventilation and filtration in limiting exposures to pollutants originating from indoor and outdoor sources. I use a simple well-mixed-air model of an indoor space to study the impact of ventilation on concentrations of ozone, nitrogen dioxide, carbon monoxide, and radon. I employ a chemical-thermodynamics-(fugacity)-based mass balance model in conjunction with a particle mass balance to study the fate and transport of particulate matter, VOCs, and SVOCs. The fugacity mass balance model accounts for chemical partitioning among air, air-borne particles, and indoor surfaces. I ran the fugacity model with indoor and outdoor source of VOCs and SVOCs and indoor and outdoor sources of particulate matter. I evaluate the consequent inhalation exposures these sources with two outcome metrics, intake fraction (iF) for indoor sources and indoor/outdoor concentration ratio for outdoor sources. The exposure to particulate matter of indoor and outdoor origin was evaluated using the outcome metrics iF and the indoor proportion of outdoor particles (iPOP). The model evaluation shows that ventilation is most effective at controlling exposures to VOCs that have an indoor source. Filtration is seen to be effective at controlling exposures to particulate matter and SVOCs that partition preferentially onto particulate matter. In Chapter 4, I explore the role of indoor air in delivering SVOCs to human occupants through passive dermal uptake. I collected wipe samples from thirteen subjects who were randomly chosen. For each subject, I collected three sequential wipe samples from the forehead and one sample from the palm. I analyzed the samples for a suite of SVOCs and skin lipids (squalene and sapienic acid) in an analytical laboratory using gas chromatography and liquid chromatography. All forehead wipe samples contained SVOCs indicating that air to skin transfer of pollutants for passive dermal uptake could be a significant exposure pathway for SVOCs. Because skin lipid concentrations decrease with depth the quantitation of skin lipid concentrations from each wipe allowed me to estimate the depth of sampling by each skin wipe. This is the first study to quantitatively evaluate the depth of sampling by skin wipes. I use the experimental results together with a theoretical model to explore the potential role of skin as a passive sampler for short-term personal exposures, indoors. For this I develop a metric called the equivalent time of exposure (ETE) to study the usefulness of sequential skin wipe samples as a passive sampler. I used partitioning coefficients from air to skin surface, combined with a dynamic skin mass transport model, to study the theoretical transport of pollutant through the stratum corneum. I compare the modeled concentrations to measured concentrations, at comparable depths. The ETE is the amount of time to which the subject would have to be exposed to a constant air concentration to attain the observed skin-wipe concentration depth profile in the stratum corneum. Based on the ETE, I find that skin wipe samples could be indicative of exposures up to 6 hours prior to wipe sampling, depending on the diffusion coefficient of the pollutant. The overarching goal of this research is to evaluate the role of indoor air in mediating the transfer to human receptors of pollutants released indoors or brought indoors from outdoor sources. The indoor air mass controls the fate and transport of pollutants in indoor spaces, and the rate of delivery of pollutants for inhalation and dermal uptake. The research highlights the important role of air-to-surface and air-to-particle partitioning in facilitating or mitigating source-receptor relationships. The work illustrates future research opportunities for tracking the complex web of indoor/outdoor pathways that bring pollutants into the human environment and into the blood and other viable tissues of the human population.
Author: Lidia Morawska
Publisher: John Wiley & Sons
ISBN: 3527609202
Category : Science
Languages : en
Pages : 467
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Book Description
Covering the fundamentals of air-borne particles and settled dust in the indoor environment, this handy reference investigates: * relevant definitions and terminology, * characteristics, * sources, * sampling techniques and instrumentation, * exposure assessment, * monitoring methods. The result is a useful and comprehensive overview for chemists, physicists and biologists, postgraduate students, medical practitioners, occupational health professionals, building owners and managers, building, construction and air-conditioning engineers, architects, environmental lawyers, government and regulatory professionals.
Author: David J. Anderson
Publisher:
ISBN:
Category :
Languages : en
Pages : 282
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Author:
Publisher: World Health Organization
ISBN:
Category : House & Home
Languages : en
Pages : 488
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Book Description
This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.
Author: Yinping Zhang
Publisher: Springer Nature
ISBN: 9811676801
Category : Science
Languages : en
Pages : 2182
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Book Description
People live in indoor environment about 90% of lifetime and an adult inhales about 15 kg air each day, over 75% of the human body’s daily mass intake (air, food, water). Therefore, indoor air quality (IAQ) is very important to human health. This book provides the basic knowledge of IAQ and highlights the research achievements in the past two decades. It covers the following 12 sections: introduction, indoor air chemicals, indoor air particles, measurement and evaluation, source/sink characteristics, indoor chemistry, human exposure to indoor pollutants, health effects and health risk assessment, IAQ and cognitive performance, standards and guidelines, IAQ control, and air quality in various indoor environments. It provides a combination of an introduction to various aspects on IAQ studies, the current state-of-knowledge, various advances and the perspective of IAQ studies. It will be very helpful for the researchers and technicians in the IAQ and the related fields. It is also useful for experts in other fields and general readers who want to obtain a basic understanding of and research advances in the field of IAQ. A group of experts in IAQ research have been recruited to write the chapters. Their research interests and experience cover the scope of the book. In addition, some experienced experts in IAQ field have been invited as advisors or reviewers to give their comments, suggestions and revisions on the handbook framework and the chapter details. Their contribution guarantees the quality of the book. We are very grateful to them. Last but not least, we express our heartfelt thanks to Prof. Spengler, Harvard University, for writing the foreword of the current Handbook of Indoor Air Quality both as a pioneer scientist who contributed greatly to indoor air science and as an Editor-in-chief of Handbook of Indoor Air Quality 2001, 1st ed. New York: McGraw-Hill. In addition to hard copies, the book is also published online and will be updated by the authors as needed to keep it aligned with current knowledge. These salient features can make the handbook fresh with the research development.
Author: Javier Alfonso Garrido
Publisher:
ISBN: 9780438290259
Category :
Languages : en
Pages :
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Book Description
Semi-volatile organic compounds (SVOCs) are ubiquitous in the indoor environment and a priority for exposure assessment because of the environmental health concerns that they pose. Direct air-to-skin dermal uptake has been shown to be relevant and comparable to the inhalation fraction for compounds with certain chemical properties. In this study, we aim to further understand the transport of these type of chemicals through the skin, specifically through the stratum corneum (SC), and we do so by collecting three subsequent forehead skin wipes, each removing pollutants deeper from the skin layers, and using this wipe analysis to determine the skin concentration profiles. The removal of SVOCs with repeated wipes reveals the concentration profiles with depth and provides a way to characterize penetration efficiency and potential to be absorbed into the bloodstream. Concentration profiles of SVOCs were simulated using a diffusive model in the skin and compared with the measured values. We found that two phthalates, dimethyl and diethyl phthalates, penetrate deeper in the skin with similar times of exposure, as compared to other phthalates and targeted SVOCs, an observation supported by the model results as well. We also report the presence of statistically significant declining patterns with skin depth for most SVOCs, indicating that their diffusion through the SC is relevant and eventually can reach the blood vessels in the vascularized dermis. Finally, different oxidationproducts, linked to respiratory irritation symptoms, formed from the reaction between ozone and squalene, were identified in the skin by a non-target approach.
Author:
Publisher: Elsevier
ISBN: 0444643400
Category : Science
Languages : en
Pages : 387
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Book Description
Analysis and Fate of Emerging Brominated and Fluorinated Organic Pollutants, Volume 87 in the Comprehensive Analytical Chemistry series, contains a wide range of topics on flame retardants in the environment, specifically focusing on halogenated flame retardants. New chapters in this release include an Introduction of emerging halogenated flame retardants in the environment, Analysis of emerging halogenated flame Retardants in environment, Toxicity of emerging halogenated organic chemicals, Occurrence and fate of emerging halogenated flame retardants in environment, Emerging halogenated flame retardants in indoor environment, Food contamination on emerging halogenated flame retardants, Human exposure to emerging halogenated flame retardants, and much more. Provides the current research results on emerging halogenated flame retardants Contains all research subjects about emerging halogenated flame retardants, from analysis to human exposure Presents critical information on halogenated flame retardants
Author: M. H. Fulekar
Publisher: I. K. International Pvt Ltd
ISBN: 9380026986
Category : Technology & Engineering
Languages : en
Pages : 296
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Book Description
Highlights the latest developments and advances in the field of nanoscience and nanotechnology and their applications in the design and development of material science and devices, energy, drug delivery, cosmetics, biology, biotechnology, tissue engineering, bioinformatics, information technology, agriculture and food, environmental protection, health risk, ethics, and regulations.
Author: Claire A. Franklin
Publisher: John Wiley & Sons
ISBN: 047001220X
Category : Technology & Engineering
Languages : en
Pages : 438
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Book Description
This timely publication concentrates on the exposure to pesticides by agricultural workers and residential users of pesticides through inhalation and physical contact. The book discusses more recently discovered risks such as pesticides on indoor carpets and includes new trends in data interpretation. Occupational & Residential Exposure Assessment for Pesticides complements the other title on pesticide exposure in the series - Pesticide Residues in Drinking Water, by Hamilton/Crossley and is a must for all professionals in the Pesticide Industry as well as academics.
