Increased Inhibition Within Frontal Corticostriatal Networks Underlies Working Memory Impairments in a Mouse Model of Neurofibromatosis Type 1 PDF Download
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Author: Carrie Shilyansky
Publisher:
ISBN:
Category :
Languages : en
Pages : 246
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Book Description
Author: Carrie Shilyansky
Publisher:
ISBN:
Category :
Languages : en
Pages : 246
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Book Description
Author: Meena Upadhyaya
Publisher: Springer Science & Business Media
ISBN: 3642328644
Category : Medical
Languages : en
Pages : 711
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Book Description
Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Author: Bernardo Barahona Corrêa
Publisher: Springer
ISBN: 331942713X
Category : Medical
Languages : en
Pages : 278
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Book Description
In this book a group of international experts guide the reader through the clinical features of adults with autism spectrum disorders, describe the care needs of patients and their families, explain the evolution of the disorders into old age, and highlight what can be done to help. Detailed attention is paid to the medical and psychiatric problems of adults with these disorders and the approach to their education and professional integration. In addition, expert neuroscientists summarize current views on the neurobiology of autism. Autism spectrum disorders are devastating neurodevelopmental disorders. Although diagnosis and therapeutic interventions usually take place in infancy, they are chronic lifelong conditions. Surprisingly, the literature on autism spectrum disorders in adults is scarce. Moreover, most mental health professionals working with adults have little training in autism, and adult mental health services around the world are rarely prepared to address the needs of these patients, which tend to increase with age. This book therefore fills a crucial gap in the literature and will prove useful for all who care for and deal with adults in the Autistic Spectrum.
Author: Randy W. Beck
Publisher: Elsevier Health Sciences
ISBN: 0702051047
Category : Medical
Languages : en
Pages : 414
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Book Description
Functional Neurology utilizes our understanding of how the nervous system works in the treatment of a variety of clinical conditions. Fuctional Neurology for Practitioners of Manual Medicine takes the reader from the embryonic beginnings of the nervous system, through the biochemistry of receptor activation and on to the functional systems of the nervous system. Both the student and the clinician will find this text a valuable source of information and clinical guidance in the application of detailed neurological principles to their practice. Concepts, relationships and scientific mechanisms of the nervous system function are covered, and this aids the practitioner in developing their clinical approach to a wide variety of patient presentations. This text explores the neurological impact of the application of functional neurological principles, using a detailed clinical approach supported by clinical case studies. The text is fully referenced, which allows the reader to immediately apply the concepts to practice situations. New for this edition are new chapters on pain (including headache) and theoretical evidence, plus extensive electronic resources supporting the text. - Utilizes our understanding of how the nervous system works in the treatment of a variety of clinical conditions - Demystifies the clinical results seen in the practice of Functional Neurology and scientifically validates its clinical success - Addresses function rather than pathology, allowing the reader to gain a firm understanding of the neurological processes seen in health and disease - Contains clinical cases which are designed to be read and answered before starting the chapter to allow the reader to gauge their current state of knowledge - 'Quick Facts' introduce new concepts or allow rapid review of information already presented in the text in a brief and succinct manner - Contains a detailed overview of the concepts relating to our understanding of the development of emotion to demonstrate the link between physical health and the mind - Contains abundant references to support controversial concepts - Contains new chapters on theoretical evidence and the management of pain (including headache) - Contains a wide range of additional case studies, 'clinical conundrums' and key questions and answers for each topic - Bonus DVD contains fully searchable text, a downloadable image bank, brain dissection and video clips of the manipulative techniques and examination procedures found within the volume plus 200 multiple choice questions
Author: Maryse Lassone
Publisher: Springer Science & Business Media
ISBN: 1461304873
Category : Medical
Languages : en
Pages : 304
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Book Description
This book is devoted to the description of agenesis of the corpus callosum, a congenital malformation of midline structures in the brain that may be regarded as a natural model of the "split-brain. " First reported by Rei! in 1812, this anomaly has since been described by several investigators. Interest in this malformation was revived in the 1970s by studies of interhemispheric transfer in Bogen and Vogel's commissurotomized patients and the subsequent findings by Sperry that acallosal patients were devoid of the typical disconnection deficits found in patients with surgical transection of the corpus callosum. Since this seminal work, the bulk of neuropsychological research on callosal agenesis has focused on the particulars of interhemispheric transfer and integration. An ever-growing literature has emerged on the subject, attempting to specify the extent and limits of neural plasticity in a nervous system that has evolved in the absence of the most important interhemispheric pathway. Whilst callosal agenesis proves to be an excellent model of cerebral plasticity, it has to be pointed out that this anomaly is often associated with other malformations and neurological diseases that may result in different degrees of mental retardation or other cognitive and sensorimotor deficits. In this context, neurological research on callosal agenesis has concentrated on the description of various syndromes associated with this pathology as well as on the attempt to specify its neurobehavioral manifestations.
Author: Hans J. ten Donkelaar
Publisher: Springer Science & Business Media
ISBN: 3540346597
Category : Medical
Languages : en
Pages : 544
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Book Description
Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.
Author: Jan E. Leestma
Publisher: CRC Press
ISBN: 1420008684
Category : Law
Languages : en
Pages : 766
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Book Description
Over the past 30 years, as both forensic pathology and neuropathology have grown in sophistication, the two specialties have forged a heightened level of interaction. Reflecting the vast increase in knowledge and scientific progress in the past two decades, Forensic Neuropathology, Second Edition examines the new developments that have arisen since
Author: Tom Strachan
Publisher: Taylor & Francis
ISBN: 1317594304
Category : Medical
Languages : en
Pages : 545
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Book Description
Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti
Author: Colin R Martin
Publisher: Academic Press
ISBN: 0128179899
Category : Psychology
Languages : en
Pages : 628
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Book Description
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions. - Provides the most comprehensive coverage of the broad range of topics relating to the neuroscience of aging - Features sections on the genetics that influences aging and diseases of aging - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables
Author: Julio Licinio
Publisher: John Wiley & Sons
ISBN: 3527616306
Category : Science
Languages : en
Pages : 599
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Book Description
This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach
