In Vitro Models of Laser Induced Injury: Pathophysiology and Cytoprotection PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 56
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Book Description
Lasers generating predominantly thermal energy are used in medicine and research for a variety of purposes including surgical excision, pan retinal photocoagulation for treating diabetic retinopathy, cornea shape remodeling, treatment of photoaged skin, and hair removal. Not surprisingly, there has been an increase in the number of laser injuries, especially eye injuries, due to laser misuse or accidents over the last four decades. When sufficient energy is provided, most visible and near infrared wavelength laser systems will damage the retinal pigment epithelium (RPE). This damage is generally due to thermal injury. Of particular concern is thermal laser injury to the macular region of the retina, which may result in a blinding trauma that produces an immediate psychological and physical debilitation. To provide rational treatments for laser-induced injury, a better understanding of the nature of this injury is required. To this end, we established methods for studying laser-induced injury with in vitro models utilizing cultured human cells.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 56
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Book Description
Lasers generating predominantly thermal energy are used in medicine and research for a variety of purposes including surgical excision, pan retinal photocoagulation for treating diabetic retinopathy, cornea shape remodeling, treatment of photoaged skin, and hair removal. Not surprisingly, there has been an increase in the number of laser injuries, especially eye injuries, due to laser misuse or accidents over the last four decades. When sufficient energy is provided, most visible and near infrared wavelength laser systems will damage the retinal pigment epithelium (RPE). This damage is generally due to thermal injury. Of particular concern is thermal laser injury to the macular region of the retina, which may result in a blinding trauma that produces an immediate psychological and physical debilitation. To provide rational treatments for laser-induced injury, a better understanding of the nature of this injury is required. To this end, we established methods for studying laser-induced injury with in vitro models utilizing cultured human cells.
Author: Jerry B. Hook
Publisher: CRC Press
ISBN: 9780881678857
Category : Medical
Languages : en
Pages : 588
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Book Description
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Author: Firas H. Kobeissy
Publisher: CRC Press
ISBN: 1466565993
Category : Medical
Languages : en
Pages : 718
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Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 874
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Book Description
Author:
Publisher: ScholarlyEditions
ISBN: 1464992819
Category : Medical
Languages : en
Pages : 520
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Book Description
Advances in Neuroglia Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroglia. The editors have built Advances in Neuroglia Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroglia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Neuroglia Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1850
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Book Description
Author: Vijay Lapsia
Publisher: Oxford University Press
ISBN: 0190611634
Category : Medical
Languages : en
Pages : 513
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Book Description
Kidney disease affects approximately ten percent of the population worldwide, with more than 2.6 million individuals estimated to be receiving renal replacement therapy. Chronic kidney disease (CKD) is fast becoming a major public health issue, with increasing incidence and death rates throughout the world. Many strategies have been proposed to reduce the growing burden of kidney disease; but while early identification and improved access to renal replacement therapies and transplantation are important, they are unlikely to solve this enormous problem. Efforts focused on primary prevention, protection, and slowing the progression of kidney disease are needed as well. Renal protection is a vital and critical component of protecting the kidneys, promoting recovery, and preventing further renal loss, yet observational data suggests that awareness of renal protection remains low and the concept of renal protection under-recognized.. Kidney Protection: A Practical Guide to Preserving Renal Function in Acute and Chronic Disease is a clinically focused review that aims to address this awareness and knowledge gap. It assembles clinically pertinent information in a concise and lucid format with the goal of helping the clinician protect the kidneys, whether in the ICU, perioperative, or out-patient setting. The authors' interdisciplinary approach is inclusive of nephrology, urology, critical care, anesthesia, and emergency medicine. Chapters review understanding kidney disease, general concepts in protecting renal function, patient selection, assessment, pharmacologic issues, and kidney protection in systemic illness. The latest evidence-based practical guidelines for optimal renal outcomes are also included.
Author: Michael R. Hamblin
Publisher: Academic Press
ISBN: 0128153067
Category : Medical
Languages : en
Pages : 658
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Book Description
Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders. - Provides a much-needed reference on photobiomodulation with an unprecedented focus on the brain and its disorders - Features a body of world-renowned editors and chapter authors that promote research, policy and funding - Discusses the recent and rapid accumulation of literature in this area of research and the shift towards the use of non-invasive techniques in therapy
Author:
Publisher:
ISBN:
Category : Gastroenterology
Languages : en
Pages : 814
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Book Description
Author: Giora Z. Feuerstein
Publisher: Springer Science & Business Media
ISBN: 9783764365110
Category : Medical
Languages : en
Pages : 664
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Book Description
New opportunities for stroke prevention and therapeutics: a hope from anti-inflammatory drugs?.- Inflammation in stroke and CNS trauma - experimental and clinical evidence.- Clinical evidence of inflammation as a risk factor in ischemic stroke.- Inflammation as a risk factor for stroke: evidence from experimental models.- Inflammatory and immune responses to CNS injury: beneficial and detrimental components.- Salutary effect of autoimmune T cells after central nervous system injury.- Traumatic brain injury: is head trauma an inflammatory disease?.- Cyclic activation and inactivation of brain vessels involving inflammatory mediators - implications for stroke.- Inflammatory cells in stroke.- Do leukocytes play a role in focal ischemia in the brain? An objective review of the literature.- The role of microglia in ischemic brain injury.- Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways.- Inflammatory cytokines, interleukins and chemokines in stroke and CNS trauma.- Cytokine effects on CNS cells: implications for the pathogenesis and prevention of stroke.- Interleukin-10 in cerebral ischemia and stroke.- Chemokines and ischemic stroke.- Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species.- Interleukin-1 and IL-1 receptor antagonist in stroke: mechanisms and potential therapeutics.- Inflammatory cytokines in CNS trauma.- Inflammation in cerebral thrombosis, angiogenesis and matrix regulation: a new perspective in stroke research and therapeutics.- Microvessel integrin expression during focal cerebral ischemia.- The inflammatory response in focal cerebral ischemia.- Chronic neuronal perturbation mediated by RAGE, a receptor for ?-sheet fibrils and S100/calgranulins.- Mediators of inflammation and blood-brain barrier permeability in cerebral ischemia.- Inflammatory proteases and oxygen radicals in stroke.- The role of metalloproteinases on blood-brain barrier breakdown after ischemic stroke.- Matrix metalloproteinases and their inhibitors in hypoxia/reoxygenation and stroke.- Extracellular matrix-degrading metalloproteinases and neuroinflammation in stroke.- Anti-oxidant strategies to treat stroke.- Inflammatory adhesion molecules, kinins, nitric oxide complement factors and lipid mediators in stroke.- Selectin-and complement-mediated mechanisms of tissue injury in stroke.- The kallikrein-kinin system in ischemic and traumatic brain injury.- Nitric oxide, nitric oxide synthases and cyclooxygenase-2 in experimental focal stroke.
