Author: M. Jager
Publisher: CRC Press
ISBN: 9789026519314
Category : Medical
Languages : en
Pages : 284
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Book Description
The eye and the ocular adnexa may give rise to over three hundred histologically different tumors - by far the largest tumor variety of the human body. However, the immunological behavior of these tumors has only been explored in some cases, although it is well established that the eye is an immune-privileged site in which cells that express foreign antigens escape immune-mediated elimination. Human tumors also create an immune-privileged surrounding and thereby escape from anti-tumor immune responses. Highlighting aspects of ocular and general tumor, this text summarizes the role of the immune system and how tumor tissue can influence various parameters (T-cells, NK-cells, HLA-expression, apoptosis), leading to escape mechanisms used by the tumor. New therapeutic regimens urgently required by patients are also reviewed, and the immunological behavior of skin melanoma is compared to choroidal melanoma, whilst basal cell carcinoma of the ocular lid is compared to those of the skin.
Author: Uwe Pleyer
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805568630
Category : Medical
Languages : en
Pages : 260
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Book Description
Although considerable light has been shed on the mechanisms of ocular immunity over the past 20 years, a complete understanding still eludes our grasp. To many ophthalmologists immunology itself is a comparatively new field. This volume will bring the latest findings in immunological research and the resulting new therapy methods to the ophthalmologist in practice. The scope of the topics goes from general principles of immuno-ophthalmology to more specific ones such as immunology of corneal transplantation or immune regulation of uveoretinal inflammation. With its broad scope of contributions, this publication will not only be significant to the ophthalmologist, but also to pediatricians, specialists in internal medicine as well as dermatologists confronted with eye diseases.
Author: Mahin Khatami
Publisher: Springer
ISBN: 3319664751
Category : Medical
Languages : en
Pages : 402
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Book Description
This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.
Author: Arun D. Singh
Publisher: Springer Science & Business Media
ISBN: 3642404898
Category : Medical
Languages : en
Pages : 239
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Book Description
Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. This volume provides essential information on cancer epidemiology, etiology, pathology, angiogenesis, immunology, genetics, and staging systems and explains the principles underlying different therapeutic approaches.
Author: Jerry Y. Niederkorn
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805581874
Category : Medical
Languages : en
Pages : 357
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Book Description
In memory of J. Wayne Streilein, the pioneer in ocular immunology The second edition of Immune Response and the Eye' highlights recent insights into the dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in Immune Response and the Eye'
Author: Hans Grossniklaus
Publisher: Springer
ISBN: 9783662508282
Category : Medical
Languages : en
Pages : 0
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Book Description
This handbook is designed to serve as a compact, up-to-date, and easy-to-use reference on the clinical features and pathology of ocular tumors. It comprises approximately 75 entries that cover the full spectrum of clinically encountered ocular tumors as well as tumor classification and other selected topics. Each entry addressing a given tumor or class of tumors is organized in a standard way, with information on synonyms, definition, etiology, clinical presentation, diagnosis, differential diagnosis, prophylaxis, therapy, prognosis, and epidemiology. Key references are also provided. The book has the advantage of having been written by members of an ocular oncology group from a leading cancer center, and will be of great practical value for ophthalmologists and ophthalmic pathologists.
Author: Eric H. Bernicker
Publisher: Springer Nature
ISBN: 3030781178
Category : Medical
Languages : en
Pages : 229
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Book Description
This book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases. Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.
Author: Glenn Dranoff
Publisher: Springer Science & Business Media
ISBN: 3642141366
Category : Medical
Languages : en
Pages : 313
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Book Description
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Author: Xuelei Ma
Publisher: Frontiers Media SA
ISBN: 2889741710
Category : Medical
Languages : en
Pages : 180
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Book Description
Author: Jerry A. Shields
Publisher: Lippincott Williams & Wilkins
ISBN: 1496321367
Category : Medical
Languages : en
Pages : 1950
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Book Description
For outstanding visual clarity in ocular diagnosis ... nothing else comes close. In this updated and revised third edition, world-renowned authorities at the Wills Eye Hospital provide outstanding guidance on recognition, evaluation, and treatment of ocular tumors, highlighted by more than 2,500 stunning photographs and surgical drawings. This unsurpassed ocular oncology resource is a comprehensive guide to the clinical features, diagnosis, management, and pathology of intraocular tumors and pseudotumors, depicting clinical variations, treatment, and histopathologic characteristics of the many varied benign and malignant lesions that affect the uveal tract, retina, and other intraocular structures. Now brought thoroughly up to date with recent clinical and scientific innovations, this unique volume has been greatly expanded with over 25% new material, and offers more high-quality images than any other text/atlas in the field. Presents each entity in an easy-to-follow format: a concise description with references on the left-hand page and six illustrations on the right-hand page. Depicts in precise photographic detail the gross and microscopic features that distinguish each condition, while professional drawings and intraoperative photographs demonstrate key surgical principles and procedures. Features numerous new references regarding diagnosis and treatment, as well as new scientific tables containing key information for your clinical practice. Features 25% new images, including panoramic images, surgical images, diagnostic testing images from multiple modalities, and updated OCT images with numerous enhanced depth imaging OCT (EDI-OCT). Covers new information on evolving conditions such as the management of choroidal nevus and melanoma with guidance for early detection using risk factors; information on the newest treatment for retinoblastoma with intra-arterial and intravenous chemotherapy; management of intraocular tumors with photodynamic therapy. Important new information on genetics of uveal melanoma, the implications of genetics, and treatment outcomes is described
