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Author: David S. Nelson
Publisher: Academic Press
ISBN: 1483274772
Category : Nature
Languages : en
Pages : 652
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Book Description
Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author: David S. Nelson
Publisher: Academic Press
ISBN: 1483274772
Category : Nature
Languages : en
Pages : 652
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Book Description
Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Khalid Hussain Bhat
Publisher: BoD – Books on Demand
ISBN: 1789846447
Category : Medical
Languages : en
Pages : 134
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Book Description
Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Bernard Burke
Publisher: Oxford University Press, USA
ISBN: 9780192631978
Category : Medical
Languages : en
Pages : 647
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Book Description
The Macrophage, second edition provides a unique, comprehensive review of the current scientific knowledge of the multifaceted role of this important and intriguing cell in health and disease. In 16 chapters, written by experts in the field, it covers the basic biology and diverse functions of macrophages in specific diseases and the complex interactions between macrophages and other cells. Ranging from their role in the defence against pathogens, their role as hosts for pathogens (including HIV), their complex roles in diseases such as arthritis and cancer, and their potential for use in novel gene therapy approaches to disease treatment, the book gives an up to the minute account of active macrophage research.
Author: Subhra K. Biswas
Publisher: Springer
ISBN: 1493913115
Category : Medical
Languages : en
Pages : 603
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Book Description
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.
Author: Vijay Kumar
Publisher: BoD – Books on Demand
ISBN: 1803556242
Category : Medical
Languages : en
Pages : 394
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Book Description
Macrophages were first discovered in 1882 when Elia Metchnikoff recognized them as important phagocytic cells that can engulf any foreign material, including fungal spores. This discovery has proved to be a milestone in establishing the field of innate immunity. Macrophages are still ruling the area after 140 years of their discovery. This book explores the diverse role of macrophages in vertebrate immunity, parasitic, bacterial, and viral infections, regeneration, inflammation, and neurological diseases.
Author: Emil Unanue
Publisher: Elsevier
ISBN: 0323146678
Category : Science
Languages : en
Pages : 540
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Book Description
Macrophage Regulation of Immunity contains the proceedings of a conference held in Augusta, Michigan, on March 12-14, 1979. The papers examine the role of macrophages in the regulation of cellular immune reactions. They highlight the interaction between macrophages and T cells, along with immune response gene control and macrophage secretion of a number of lymphostimulatory molecules. Organized into six sections encompassing 35 chapters, this volume begins with an overview of antigen handling and presentation, immune response gene control, antigen-presenting cells, and factors affecting lymphocyte-macrophage interactions. It then discusses genetic control of T cell-macrophage interaction in helper cell induction in vitro; mechanisms underlying the interaction of guinea pig T lymphocytes with antigen-pulsed macrophages; and secretion of arachidonic acid oxygenation products by mononuclear phagocytes and their possible role as modulators of lymphocyte function. The book also covers regulation of intracellular killing by extracellular stimulation of the monocyte membrane, and adjuvant activation of macrophage functions. Students and scientists will find this book extremely helpful.
Author: Sigurd J. Normann
Publisher: Springer Science & Business Media
ISBN: 1468443941
Category : Medical
Languages : en
Pages : 814
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Book Description
This book is the outcome of a meeting held in Davos, Switzerland, February 7-12, 1982 focused primarily on mononuclear phagocytes and on natural killer (NK) cells. This IX International RES Congress was attended by 489 scientists from 31 countries and there were 340 scientific presentations in oral or poster session. The essential purpose of the Congress was to bring together scientists representing various aspects of mononuclear phagocyte biology to review and examine cri~ically the effects and mechanisms of macrophage growth control as well as the participatio~ of these cells in the afferent and efferent limbs of the immune response. Additional topics included the production and distribution of mono nuclear phagocytes; the intrinsic and extrinsic regulation of these cells; and the origin, nature, function and regulation of NK cells. The ultimate goal of the Congress was to enhance communication between scientists in various countries and disciplines so that new research directives could be defined with which to explore basic aspects of macrophage and NK cell participation in the control of cancer and infection.
Author: Niels Olson Saraiva Camara
Publisher: Academic Press
ISBN: 0128213868
Category : Medical
Languages : en
Pages : 324
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Book Description
Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential. Covers translational aspects where there is research support to indicate potential therapeutic potential Aims at presenting a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics Introduces Macrophages generally and dive into the organ/tissue/specific representations covering their phenotype, function, and metabolic characteristics Brings updated aspects of macrophages biology
