If You Give a Mouse Metformin

If You Give a Mouse Metformin PDF Author: Nikhil Krishnan
Publisher:
ISBN:
Category :
Languages : en
Pages : 45

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Book Description
Learn how clinical trials work in a fun, satirical, and kid-friendly way! A scientist and a mouse learn what it takes to develop a drug. Along the way they'll encounter a cast of characters including doctors, the FDA, other animals, and the clinical trial complex. Have you ever wanted to know how drug development works, but too scared to ask? Now you can say you're buying a book for a child, but it's actually for you. This book is a great gift for anyone in the healthcare field, or any baby that wants to learn how double-blind placebo controlled trials work. A great gag gift for baby showers, secret Santa, holidays, weddings, divorces (?), med school graduations, work anniversaries, new employees. An Out-Of-Pocket Production. Learn more at www.outofpocket.health

If You Give a Mouse Metformin

If You Give a Mouse Metformin PDF Author: Nikhil Krishnan
Publisher:
ISBN:
Category :
Languages : en
Pages : 45

Get Book Here

Book Description
Learn how clinical trials work in a fun, satirical, and kid-friendly way! A scientist and a mouse learn what it takes to develop a drug. Along the way they'll encounter a cast of characters including doctors, the FDA, other animals, and the clinical trial complex. Have you ever wanted to know how drug development works, but too scared to ask? Now you can say you're buying a book for a child, but it's actually for you. This book is a great gift for anyone in the healthcare field, or any baby that wants to learn how double-blind placebo controlled trials work. A great gag gift for baby showers, secret Santa, holidays, weddings, divorces (?), med school graduations, work anniversaries, new employees. An Out-Of-Pocket Production. Learn more at www.outofpocket.health

The Health Care Handbook

The Health Care Handbook PDF Author: Elisabeth T. Askin
Publisher: Lippincott Williams & Wilkins
ISBN: 1975200047
Category : Medical
Languages : en
Pages : 191

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Book Description
Described in the New York Times as “an astonishingly clear ‘user’s manual’ that explains our health care system and the policies that will change it,” The Health Care Handbook, by Drs. Elisabeth Askin and Nathan Moore, offers a practical, neutral, and readable overview of the U.S. health care system in a compact, convenient format. The fully revised third edition provides concise coverage on health care delivery, insurance and economics, policy, and reform—all critical components of the system in which health care professionals work. Written in a conversational and accessible tone, this popular, highly regarded handbook serves as a “one stop shop” for essential facts, systems, concepts, and analysis of the U.S. health care system, providing the tools you need to confidently evaluate current health care policy and controversies.

Diabetes and Metformin

Diabetes and Metformin PDF Author: Hendrik Michiel Jan Krans
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 68

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Book Description


Lifespan

Lifespan PDF Author: David A. Sinclair
Publisher: Atria Books
ISBN: 1501191977
Category : Science
Languages : en
Pages : 432

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Book Description
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Metformin: Beyond Diabetes

Metformin: Beyond Diabetes PDF Author: Frederic Bost
Publisher: Frontiers Media SA
ISBN: 2889634078
Category :
Languages : en
Pages : 134

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Book Description


Let's Never Talk About This Again

Let's Never Talk About This Again PDF Author: Sara Faith Alterman
Publisher: Hachette UK
ISBN: 1538748657
Category : Biography & Autobiography
Languages : en
Pages : 272

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Book Description
Samantha Irby meets Bettyville in this darkly funny and poignant memoir about love, loss, Alzheimer's, and reviving her father's pornographic writing career, from writer and Mortified liveproducer Sara Faith Alterman. Twelve-year-old Sara enjoyed an G-rated existence in suburban New England, filled with over-the-top birthday cakes, Revolutionary War reenactments, and nerdy word games invented by her prudish father, Ira. But Sara's world changed for the icky when she discovered that Ira had been shielding her from the truth: that he was a campy sex writer who'd sold millions of books in multiple languages, including the wildly popular Games You Can Play with Your Pussy. Which was, to the naïve Sara's horror, not a book about cats. For decades the books remained an unspoken family secret, until Ira developed early onset Alzheimer's disease . . . and announced he'd be reviving his writing career. With Sara's help. In this cringeworthy, hilarious, and moving memoir, Sara shares the profound experience of discovering new facets of her father; once as a child, and again as an adult. Let's Never Talk About This Again is a must-read confessional from a woman who spent years trying to find humor in the perverse and optimism in the darkness, and succeeded.

Metformin

Metformin PDF Author: Juber Akhtar
Publisher: BoD – Books on Demand
ISBN: 1839696052
Category : Medical
Languages : en
Pages : 155

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Book Description
Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus (NIDDM), is a condition in which cells fail to respond to insulin properly. As the disease progresses, the body does not produce enough insulin. There are several classes of anti-diabetic medications available, including the oral agent metformin. This medication is recommended as first-line treatment for T2D, except for those patients with severe kidney or liver problems. This book discusses the molecular mechanism, pharmacokinetics, and uses of metformin, as well as presents information on adverse drug reactions, drug interactions, and the potential use of metformin in tuberculosis.

Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance

Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance PDF Author: Jurgen Brockmoller
Publisher: Frontiers Media SA
ISBN: 2889740293
Category : Science
Languages : en
Pages : 145

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Book Description
Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?

Where Are You, Moon?

Where Are You, Moon? PDF Author: Charlotte a Lee
Publisher: Bad Mouse Publishing
ISBN: 9780990535393
Category :
Languages : en
Pages : 24

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Book Description
Eleanor and her Grandma go for a pre-dawn walk among the trees. The moon is there to light the way, but when it disappears, Eleanor wonders,

Pharmacological and Dietary Interventions for the Treatment of Diabetes in Mouse Models

Pharmacological and Dietary Interventions for the Treatment of Diabetes in Mouse Models PDF Author: Markus Florian Scheerer
Publisher:
ISBN: 9783830084433
Category :
Languages : en
Pages : 234

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Book Description