IDENTIFYING THE SIZE OF ISCHEMIC PENUMBRA BY BLOOD-BASED BIOMARKERS: IS IT POSSIBLE? PDF Download
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Author: Lu00e1szlu00f3 Szapu00e1ry
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Background: Selecting patients for recanalization procedures by assessing the size of salvageable brain tissue is playing an increasing role in stroke care, although currently it is based mainly on imaging methods. There is no validated biomarker for patient selection. However, several articles have reported on proteins that are appear only in the penumbra during ischemic stroke, some of which also appear in the peripheral blood during the acute phase.Aim:Our aim is to find blood-based biomarkers which can predict the amount of the salvageable brain tissue and can be potential candidates for extensive clinical use.Methods:In our department stroke patients are enrolled to a comprehensive Stroke-Registry since November 2017. Our database contains detailed data on medical history, symptoms, management and therapy, aetiology, follow-up data and outcomes of 200 patients so far. Blood samples are collected three times (on admission, at 24h and at 72h after stroke onset) from all included patients and stored in our Stroke-Biobank for later analysis. All patients who meet the eligibility criteria undergo CT-perfusion imaging, which is assessed manually and automatically by the Olea Sphereu00ae software.Conclusion:Our Stroke-Registry and our Stroke-Biobank gives us the chance to investigate multiple biomarkers in a notable number of cases. Currently we are examining the clinical utility of Heat Shock Protein 70 (HSP70) and S100 calcium-binding protein B (S100B). We will examine whether the serum levels of these biomarkers are correlating with the approximation of core infarct (S100B) and region of penumbra (HSP70) on the CT-perfusion scan.
Author: Lu00e1szlu00f3 Szapu00e1ry
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Background: Selecting patients for recanalization procedures by assessing the size of salvageable brain tissue is playing an increasing role in stroke care, although currently it is based mainly on imaging methods. There is no validated biomarker for patient selection. However, several articles have reported on proteins that are appear only in the penumbra during ischemic stroke, some of which also appear in the peripheral blood during the acute phase.Aim:Our aim is to find blood-based biomarkers which can predict the amount of the salvageable brain tissue and can be potential candidates for extensive clinical use.Methods:In our department stroke patients are enrolled to a comprehensive Stroke-Registry since November 2017. Our database contains detailed data on medical history, symptoms, management and therapy, aetiology, follow-up data and outcomes of 200 patients so far. Blood samples are collected three times (on admission, at 24h and at 72h after stroke onset) from all included patients and stored in our Stroke-Biobank for later analysis. All patients who meet the eligibility criteria undergo CT-perfusion imaging, which is assessed manually and automatically by the Olea Sphereu00ae software.Conclusion:Our Stroke-Registry and our Stroke-Biobank gives us the chance to investigate multiple biomarkers in a notable number of cases. Currently we are examining the clinical utility of Heat Shock Protein 70 (HSP70) and S100 calcium-binding protein B (S100B). We will examine whether the serum levels of these biomarkers are correlating with the approximation of core infarct (S100B) and region of penumbra (HSP70) on the CT-perfusion scan.
Author: Philip V. Peplow
Publisher: Humana
ISBN: 9781493996810
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume presents the latest data on recent achievements in new and emerging technologies for stroke biomarkers and innovations in stroke assessment. The topics discussed in this book explore the role of upcoming biomarkers in different types of stroke, and explores techniques that will allow researchers to be more effective when approaching clinical management and patient care. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to ensure successful results in the laboratory. Cutting-edge and comprehensive, Stroke Biomarkers is a valuable resource for both experimental and clinical scientists interested in expanding their knowledge in the field of stroke research.
Author: R. Gilberto González
Publisher: Springer Science & Business Media
ISBN: 3642127517
Category : Medical
Languages : en
Pages : 299
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Book Description
This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Author: E. Steve Roach
Publisher: Cambridge University Press
ISBN: 1139855581
Category : Medical
Languages : en
Pages : 445
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Book Description
Toole's Cerebrovascular Disorders was the first modern book devoted to care of the stroke, originally published more than 40 years ago. This is a completely revised and updated sixth edition of the highly respected standard for stroke diagnosis and treatment. Dr James Toole has stayed on as a consultant for the text, and Drs E. Steve Roach, Kerstin Bettermann, and Jose Biller have reworked Dr Toole's book to include chapters on genetics, pregnancy-related stroke, and acute treatments. The practical focus of the book has not changed, retaining its emphasis on bedside diagnosis and treatment. Easily accessible both for stroke specialists and residents, the sixth edition has been modernized to keep pace with the rapid expansion of knowledge in stroke care and includes evidence-based recommendations, the latest technology and imaging, and risk factors. The text is supplemented with more than 200 images, many in color.
Author: Ulrich Dirnagl
Publisher: Springer Science & Business Media
ISBN: 3662054264
Category : Medical
Languages : en
Pages : 248
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Book Description
The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Author: Leonardo Pantoni
Publisher: Cambridge University Press
ISBN: 1107031664
Category : Medical
Languages : en
Pages : 375
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Book Description
Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Author: Stefan Schwab
Publisher: Cambridge University Press
ISBN: 1139991558
Category : Medical
Languages : en
Pages : 579
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Book Description
New and groundbreaking therapeutic options for the critical care of patients with cerebrovascular disease have improved patient management, minimized morbidity, reduced in-patient care, improved quality of life, and had a positive economic impact on health service provision. This volume integrates these approaches and suggests the best therapy option for all cerebrovascular conditions. The early chapters of the book focus on monitoring techniques and interventions. Subsequent sections address the critical care of a wide range of cerebrovascular diseases: ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, arteriovenous malformations, cerebral venous thrombosis and traumatic injury. The editors and authors are internationally recognized experts in their field, and the text is supplemented by tables and illustrations to demonstrate important clinical findings. This book will meet the needs of stroke physicians, neurologists, neurosurgeons, neurointensivists and interventional neuroradiologists seeking to maximize positive outcomes for their patients.
Author: Victor I. Mikla
Publisher: Elsevier
ISBN: 0124170366
Category : Technology & Engineering
Languages : en
Pages : 156
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Book Description
Medical Imaging Technology reveals the physical and materials principles of medical imaging and image processing, from how images are obtained to how they are used. It covers all aspects of image formation in modern imaging modalities and addresses the techniques, instrumentation, and advanced materials used in this rapidly changing field. Covering conventional and modern medical imaging techniques, this book encompasses radiography, fluoroscopy, computed tomography, magnetic resonance imaging, ultrasound, and Raman spectroscopy in medicine. In addition to the physical principles of imaging techniques, the book also familiarizes you with the equipment and procedures used in diagnostic imaging. Addresses the techniques, instrumentation, and advanced materials used in medical imaging Provides practical insight into the skills, tools, and procedures used in diagnostic imaging Focuses on selenium imagers and chalcogenide glasses
Author: Michael Brainin
Publisher: Cambridge University Press
ISBN: 1107047498
Category : Medical
Languages : en
Pages : 425
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Book Description
Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.
Author: Steven C. Cramer
Publisher: Cambridge University Press
ISBN: 1139490656
Category : Medical
Languages : en
Pages : 307
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Book Description
Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
