IDENTIFICATION AND ANALYSIS OF NOVEL GENES INVOLVED IN CELLULAR MORPHOGENESIS IN SACCHAROMYCES CEREVISIAE (CYTOSKELETON, BUD SITE). PDF Download
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Author: KATHLEEN CORRADO
Publisher:
ISBN:
Category :
Languages : en
Pages : 194
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the germinated spores display no obvious terminal phenotype.
Author: KATHLEEN CORRADO
Publisher:
ISBN:
Category :
Languages : en
Pages : 194
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Book Description
the germinated spores display no obvious terminal phenotype.
Author: Christian Josef Hubert Hofmann
Publisher:
ISBN:
Category :
Languages : en
Pages : 420
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Author: Shanshan Tuo
Publisher:
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Category :
Languages : en
Pages :
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This dissertation describes investigations of the machinery of cell polarization in the budding yeast Saccharomyces cerevisiae. Cell polarization is an essential feature of most, if not all, cell types. It occurs in two steps: (1) the selection of an axis and (2) the asymmetric organization of organelles, the cytoskeleton, and plasma-membrane components along this axis. The selection of an axis in S. cerevisiae is manifested as bud-site selection. S. cerevisiae cells select bud sites in either of two patterns, known as the axial and bipolar, depending on the mating type of the cells. Normal haploid cells use the axial pattern, whereas normal diploid cells use the bipolar pattern. Beginning with a re-analysis of the phenotypes of 38 mutants reported in a genome-wide screen to be defective in bipolar-bud-site selection, I focused on two groups of mutants with distinct phenotypes and tried to elucidate the molecular mechanisms underlying these phenotypes. The first group contains two mutants, bud13[Delta] and ist3[Delta]; the second group contains 14 endocytosis-related mutants. Each group has led to a separate story of how the corresponding proteins are involved in bipolar-bud-site selection. First, I found (Chapter 2) that Bud13 and Ist3 are responsible specifically for the efficient pre-mRNA splicing of MATa1, which encodes a cell-type-specific regulator for the expression of haploid-specific genes. One of these genes, AXL1, encodes a protein whose ectopic expression in diploid cells causes override of the bipolar-budding mechanism by the axial budding mechanism. Second, I found (Chapter 3) that endocytosis-related proteins are involved in maintaining the localization, and thus the function, of bipolar marker proteins including Bud8 and Bud9.
Author: Aron Richard Marquitz
Publisher:
ISBN:
Category : Cell cycle
Languages : en
Pages : 280
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Author: Zhixiong Xiao
Publisher:
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Category : Chromosomes
Languages : en
Pages : 388
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Author:
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Category : Cells
Languages : en
Pages : 1132
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Author: Jian Zou
Publisher:
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Category :
Languages : en
Pages :
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Author: Peter A. Hall
Publisher: John Wiley & Sons
ISBN: 9780470779699
Category : Science
Languages : en
Pages : 380
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"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." –Microbiology Today, May 2009 Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions. This book comprehensively examines the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila. A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed. In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences. This book is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.
Author: Le Hoa Tan
Publisher:
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Category :
Languages : en
Pages :
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Author: Lauren Frances Stevenson
Publisher:
ISBN:
Category : Saccharomyces cerevisiae
Languages : en
Pages : 442
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