Identifiability and Regression Analysis of Biological Systems Models PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Identifiability and Regression Analysis of Biological Systems Models PDF full book. Access full book title Identifiability and Regression Analysis of Biological Systems Models by Paola Lecca. Download full books in PDF and EPUB format.
Author: Paola Lecca
Publisher: Springer Nature
ISBN: 3031747488
Category :
Languages : en
Pages : 130
Get Book Here
Book Description
Author: Paola Lecca
Publisher: Springer Nature
ISBN: 3031747488
Category :
Languages : en
Pages : 130
Get Book Here
Book Description
Author: Paola Lecca
Publisher:
ISBN: 9783030412562
Category : Biochemistry
Languages : en
Pages : 90
Get Book Here
Book Description
This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection. Although the main fields of application discussed in the book are biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to deal with problems such as determining the identifiability conditions, searching for an identifiable model, and conducting their own regression analysis and diagnostics without supervision. Featuring a wealth of real-world examples, exercises, and codes in R, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Readers should be familiar with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R.
Author: Jan de Gier
Publisher: Springer Nature
ISBN: 3030624978
Category : Mathematics
Languages : en
Pages : 798
Get Book Here
Book Description
MATRIX is Australia’s international and residential mathematical research institute. It facilitates new collaborations and mathematical advances through intensive residential research programs, each 1-4 weeks in duration. This book is a scientific record of the ten programs held at MATRIX in 2019 and the two programs held in January 2020: · Topology of Manifolds: Interactions Between High and Low Dimensions · Australian-German Workshop on Differential Geometry in the Large · Aperiodic Order meets Number Theory · Ergodic Theory, Diophantine Approximation and Related Topics · Influencing Public Health Policy with Data-informed Mathematical Models of Infectious Diseases · International Workshop on Spatial Statistics · Mathematics of Physiological Rhythms · Conservation Laws, Interfaces and Mixing · Structural Graph Theory Downunder · Tropical Geometry and Mirror Symmetry · Early Career Researchers Workshop on Geometric Analysis and PDEs · Harmonic Analysis and Dispersive PDEs: Problems and Progress The articles are grouped into peer-reviewed contributions and other contributions. The peer-reviewed articles present original results or reviews on a topic related to the MATRIX program; the remaining contributions are predominantly lecture notes or short articles based on talks or activities at MATRIX.
Author: Paola Lecca
Publisher: Springer
ISBN: 9783031747472
Category : Computers
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Andreas Kremling
Publisher: CRC Press
ISBN: 1466567899
Category : Mathematics
Languages : en
Pages : 382
Get Book Here
Book Description
Drawing on the latest research in the field, Systems Biology: Mathematical Modeling and Model Analysis presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are systematically applied in biotechnology. The first part of the book introduces biological basics, such as metabolism, signaling, gene expression, and control as well as mathematical modeling fundamentals, including deterministic models and thermodynamics. The text also discusses linear regression methods, explains the differences between linear and nonlinear regression, and illustrates how to determine input variables to improve estimation accuracy during experimental design. The second part covers intracellular processes, including enzymatic reactions, polymerization processes, and signal transduction. The author highlights the process–function–behavior sequence in cells and shows how modeling and analysis of signal transduction units play a mediating role between process and function. The third part presents theoretical methods that address the dynamics of subsystems and the behavior near a steady state. It covers techniques for determining different time scales, sensitivity analysis, structural kinetic modeling, and theoretical control engineering aspects, including a method for robust control. It also explores frequent patterns (motifs) in biochemical networks, such as the feed-forward loop in the transcriptional network of E. coli. Moving on to models that describe a large number of individual reactions, the last part looks at how these cellular models are used in biotechnology. The book also explains how graphs can illustrate the link between two components in large networks with several interactions.
Author: Ewart Carson
Publisher: Elsevier
ISBN: 0080511902
Category : Mathematics
Languages : en
Pages : 437
Get Book Here
Book Description
Modelling Methodology for Physiology and Medicine offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modelling methodology that is widely applicable to physiology and medicine. The book opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. - Builds upon and enhances the readers existing knowledge of modelling methodology and practice - Editors are internationally renowned leaders in their respective fields
Author: Rolf Isermann
Publisher: Springer
ISBN: 9783540871552
Category : Technology & Engineering
Languages : en
Pages : 705
Get Book Here
Book Description
Precise dynamic models of processes are required for many applications, ranging from control engineering to the natural sciences and economics. Frequently, such precise models cannot be derived using theoretical considerations alone. Therefore, they must be determined experimentally. This book treats the determination of dynamic models based on measurements taken at the process, which is known as system identification or process identification. Both offline and online methods are presented, i.e. methods that post-process the measured data as well as methods that provide models during the measurement. The book is theory-oriented and application-oriented and most methods covered have been used successfully in practical applications for many different processes. Illustrative examples in this book with real measured data range from hydraulic and electric actuators up to combustion engines. Real experimental data is also provided on the Springer webpage, allowing readers to gather their first experience with the methods presented in this book. Among others, the book covers the following subjects: determination of the non-parametric frequency response, (fast) Fourier transform, correlation analysis, parameter estimation with a focus on the method of Least Squares and modifications, identification of time-variant processes, identification in closed-loop, identification of continuous time processes, and subspace methods. Some methods for nonlinear system identification are also considered, such as the Extended Kalman filter and neural networks. The different methods are compared by using a real three-mass oscillator process, a model of a drive train. For many identification methods, hints for the practical implementation and application are provided. The book is intended to meet the needs of students and practicing engineers working in research and development, design and manufacturing.
Author: S.J. Welham
Publisher: CRC Press
ISBN: 1439898057
Category : Mathematics
Languages : en
Pages : 592
Get Book Here
Book Description
Written in simple language with relevant examples, this illustrative introductory book presents best practices in experimental design and simple data analysis. Taking a practical and intuitive approach, it only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R.
Author: Peter van Overschee
Publisher: Springer Science & Business Media
ISBN: 1461304652
Category : Technology & Engineering
Languages : en
Pages : 263
Get Book Here
Book Description
Subspace Identification for Linear Systems focuses on the theory, implementation and applications of subspace identification algorithms for linear time-invariant finite- dimensional dynamical systems. These algorithms allow for a fast, straightforward and accurate determination of linear multivariable models from measured input-output data. The theory of subspace identification algorithms is presented in detail. Several chapters are devoted to deterministic, stochastic and combined deterministic-stochastic subspace identification algorithms. For each case, the geometric properties are stated in a main 'subspace' Theorem. Relations to existing algorithms and literature are explored, as are the interconnections between different subspace algorithms. The subspace identification theory is linked to the theory of frequency weighted model reduction, which leads to new interpretations and insights. The implementation of subspace identification algorithms is discussed in terms of the robust and computationally efficient RQ and singular value decompositions, which are well-established algorithms from numerical linear algebra. The algorithms are implemented in combination with a whole set of classical identification algorithms, processing and validation tools in Xmath's ISID, a commercially available graphical user interface toolbox. The basic subspace algorithms in the book are also implemented in a set of Matlab files accompanying the book. An application of ISID to an industrial glass tube manufacturing process is presented in detail, illustrating the power and user-friendliness of the subspace identification algorithms and of their implementation in ISID. The identified model allows for an optimal control of the process, leading to a significant enhancement of the production quality. The applicability of subspace identification algorithms in industry is further illustrated with the application of the Matlab files to ten practical problems. Since all necessary data and Matlab files are included, the reader can easily step through these applications, and thus get more insight in the algorithms. Subspace Identification for Linear Systems is an important reference for all researchers in system theory, control theory, signal processing, automization, mechatronics, chemical, electrical, mechanical and aeronautical engineering.
Author: Peter H. Westfall
Publisher: CRC Press
ISBN: 100006963X
Category : Business & Economics
Languages : en
Pages : 453
Get Book Here
Book Description
Understanding Regression Analysis unifies diverse regression applications including the classical model, ANOVA models, generalized models including Poisson, Negative binomial, logistic, and survival, neural networks, and decision trees under a common umbrella -- namely, the conditional distribution model. It explains why the conditional distribution model is the correct model, and it also explains (proves) why the assumptions of the classical regression model are wrong. Unlike other regression books, this one from the outset takes a realistic approach that all models are just approximations. Hence, the emphasis is to model Nature’s processes realistically, rather than to assume (incorrectly) that Nature works in particular, constrained ways. Key features of the book include: Numerous worked examples using the R software Key points and self-study questions displayed "just-in-time" within chapters Simple mathematical explanations ("baby proofs") of key concepts Clear explanations and applications of statistical significance (p-values), incorporating the American Statistical Association guidelines Use of "data-generating process" terminology rather than "population" Random-X framework is assumed throughout (the fixed-X case is presented as a special case of the random-X case) Clear explanations of probabilistic modelling, including likelihood-based methods Use of simulations throughout to explain concepts and to perform data analyses This book has a strong orientation towards science in general, as well as chapter-review and self-study questions, so it can be used as a textbook for research-oriented students in the social, biological and medical, and physical and engineering sciences. As well, its mathematical emphasis makes it ideal for a text in mathematics and statistics courses. With its numerous worked examples, it is also ideally suited to be a reference book for all scientists.
