Author: James Curtis Barrow
Publisher:
ISBN:
Category : Fungi
Languages : en
Pages : 448
Book Description
I. Approaches Toward the Synthesis of the Zaragozic Acid Bicyclic Ketal Core
Author: James Curtis Barrow
Publisher:
ISBN:
Category : Fungi
Languages : en
Pages : 448
Book Description
Publisher:
ISBN:
Category : Fungi
Languages : en
Pages : 448
Book Description
Part 1, Synthesis of Zaragozic Acid A
Author: Eddy Wai Tsun Yue
Publisher:
ISBN: 9780591157222
Category : Anticholesteremic agents
Languages : en
Pages : 922
Book Description
Part 1: Synthesis of Zaragozic Acid A. The first synthesis of zaragozic acid A, an extremely potent inhibitor of squalene synthase, is described. The coupling of the C-1 alkyl dithiane side chain to the key intermediate aldehyde illustrated the high convergency of this approach. Enantioselective syntheses of the C-1 alkyl side chain and the C-6 acyl side chain as well as the successful conversion of the acyclic precursor to the bicyclic ketal core of the zaragozic acids were key elements of this synthesis. Part 2: Synthetic Studies Directed Towards Maitotoxin. A new strategy to synthesize the alkyl-alkyl linkages of maitotoxin is described. Model systems of the JKL, OPQ, and UVW ring systems of maitotoxin were synthesized via the ring closing metathesis of olefinic alcohols with Tebbe reagent. The formation of cis-decalin enol ethers and the use of dimethyl titanocene for substrates bearing a heteroatom substituent next to the olefin were key discoveries.
Publisher:
ISBN: 9780591157222
Category : Anticholesteremic agents
Languages : en
Pages : 922
Book Description
Part 1: Synthesis of Zaragozic Acid A. The first synthesis of zaragozic acid A, an extremely potent inhibitor of squalene synthase, is described. The coupling of the C-1 alkyl dithiane side chain to the key intermediate aldehyde illustrated the high convergency of this approach. Enantioselective syntheses of the C-1 alkyl side chain and the C-6 acyl side chain as well as the successful conversion of the acyclic precursor to the bicyclic ketal core of the zaragozic acids were key elements of this synthesis. Part 2: Synthetic Studies Directed Towards Maitotoxin. A new strategy to synthesize the alkyl-alkyl linkages of maitotoxin is described. Model systems of the JKL, OPQ, and UVW ring systems of maitotoxin were synthesized via the ring closing metathesis of olefinic alcohols with Tebbe reagent. The formation of cis-decalin enol ethers and the use of dimethyl titanocene for substrates bearing a heteroatom substituent next to the olefin were key discoveries.
Dissertation Abstracts International
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 846
Book Description
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 846
Book Description
Chemical Abstracts
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2726
Book Description
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2726
Book Description
Synthetic Approach to the Zaragozic Acid Core
Author: Linda Joy Brzezinski
Publisher:
ISBN:
Category : Blood cholesterol
Languages : en
Pages : 478
Book Description
Publisher:
ISBN:
Category : Blood cholesterol
Languages : en
Pages : 478
Book Description
American Doctoral Dissertations
Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 848
Book Description
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 848
Book Description
The Synthesis of the Fully Functionalized Core of the Zaragozic Acids/squalestatins
Author: Susan La Greca
Publisher:
ISBN:
Category :
Languages : en
Pages : 920
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 920
Book Description
Carbohydrate Chemistry
Author: R J Ferrier
Publisher: Royal Society of Chemistry
ISBN: 1847553117
Category : Science
Languages : en
Pages : 432
Book Description
Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Publisher: Royal Society of Chemistry
ISBN: 1847553117
Category : Science
Languages : en
Pages : 432
Book Description
Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Synthetic Studies of the Aristotelia Alkaloids
Author: Doris Stoermer
Publisher:
ISBN:
Category :
Languages : en
Pages : 442
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 442
Book Description
Desymmetrization by Ketalization/ring-closing Metathesis
Author: Eric Allan Voight
Publisher:
ISBN:
Category :
Languages : en
Pages : 368
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 368
Book Description