Human Stem Cell Toxicology PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Human Stem Cell Toxicology PDF full book. Access full book title Human Stem Cell Toxicology by James L Sherley. Download full books in PDF and EPUB format.
Author: James L Sherley
Publisher: Royal Society of Chemistry
ISBN: 1782626786
Category : Medical
Languages : en
Pages : 316
Get Book Here
Book Description
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Author: James L Sherley
Publisher: Royal Society of Chemistry
ISBN: 1782626786
Category : Medical
Languages : en
Pages : 316
Get Book Here
Book Description
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Author: Saura C. Sahu
Publisher: John Wiley & Sons
ISBN: 1119135435
Category : Science
Languages : en
Pages : 1010
Get Book Here
Book Description
A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Author: Theodore P. Rasmussen
Publisher: John Wiley & Sons
ISBN: 1119283213
Category : Science
Languages : en
Pages : 384
Get Book Here
Book Description
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
Author: Shiva Prasad Potta
Publisher:
ISBN:
Category : Science
Languages : en
Pages :
Get Book Here
Book Description
Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology - An overview.
Author: Saura C. Sahu
Publisher: John Wiley & Sons
ISBN: 1118855868
Category : Science
Languages : en
Pages : 713
Get Book Here
Book Description
The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Author: Shripriya Singh
Publisher: Mohammed Abdul Malik
ISBN:
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
In "Stem Cell Study: Organ-Specific Responses to Xenobiotics," Shripriya Singh explores the exciting field of stem cell research and its applications in detecting organ-specific responses to xenobiotics. This book provides a comprehensive overview of the use of stem cells for toxicology studies and their potential for identifying organ-specific responses to xenobiotics. The book begins with an introduction to stem cells and their properties, followed by a discussion of the various types of xenobiotics and their effects on human health. Singh then delves into the techniques used for stem cell culture and differentiation, including 3D cell culture and microfluidic platforms. The book then moves on to the applications of stem cells in toxicology studies, focusing on the detection of organ-specific responses to xenobiotics. Singh discusses the use of various types of stem cells, such as induced pluripotent stem cells (iPSCs) and organoids, for toxicology studies. The author also presents case studies on the use of stem cells for detecting organ-specific responses to xenobiotics, such as the liver and the kidney. Overall, "Stem Cell Study: Organ-Specific Responses to Xenobiotics" is an informative and insightful book for researchers, scientists, and clinicians working in the field of toxicology and stem cell research. The author provides a comprehensive understanding of the potential of stem cells for detecting organ-specific responses to xenobiotics, which is crucial for improving drug development and human health.
Author: Mike Clements
Publisher: Methods in Pharmacology and To
ISBN: 9781493982646
Category : Medical
Languages : en
Pages : 356
Get Book Here
Book Description
Author: M.A. Hayat
Publisher: Springer Science & Business Media
ISBN: 9400724152
Category : Medical
Languages : en
Pages : 394
Get Book Here
Book Description
It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described.
Author: Philip H. Schwartz
Publisher: Humana Press
ISBN: 9781617792007
Category : Science
Languages : en
Pages : 468
Get Book Here
Book Description
Almost daily, new technologies are being presented that move the field of human pluripotent stem cell research towards a future that may yield highly-effective, personalized medical treatments. Three enabling technologies at hand for human PSCs are 1) directed reprogramming of somatic cells, which eliminate many of the ethical issues associated with the derivation and use of human PSCs, increase genetic diversity of the available human PSC lines, and give rise to better in vitro human disease models; 2) the discovery that a Rho-associated protein Kinase (ROCK) inhibitor allows for efficient single cell passaging and cryopreservation, increasing the efficiency and reliability of hPSC culture; and 3) defined, animal-component-free media, which lay the groundwork for simplified scale-up for therapeutic applications, differentiation protocols, and toxicology screens. The aforementioned technologies can be found in Human Pluripotent Stem Cells: Methods and Protocols, a compilation of 33 detailed protocols in six categories of PSC research that cover laboratory essentials and the derivation of new PSC lines, including induced PSC lines, as well as their growth, maintenance, characterization, genetic manipulation, and differentiation. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Human Pluripotent Stem Cells: Methods and Protocols serves as an ideal guide to scientists conducting their own pluripotent cell research programs and makes great strides towards furthering human knowledge and, ultimately, improving the human condition.
Author: C. K. Atterwill
Publisher: Cambridge University Press
ISBN: 9780521326841
Category : Medical
Languages : en
Pages : 490
Get Book Here
Book Description
The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.
