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Author: Miroslav Blumenberg
Publisher: BoD – Books on Demand
ISBN: 1789230942
Category : Medical
Languages : en
Pages : 214
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Book Description
Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
Author: Miroslav Blumenberg
Publisher: BoD – Books on Demand
ISBN: 1789230942
Category : Medical
Languages : en
Pages : 214
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Book Description
Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
Author: Stephen N. Snow
Publisher: Univ of Wisconsin Press
ISBN: 9780299204709
Category : Medical
Languages : en
Pages : 464
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Book Description
Mohs Micrographic Surgery, an advanced treatment procedure for skin cancer, offers the highest potential for recovery--even if the skin cancer has been previously treated. This procedure is a state-of-the-art treatment in which the physician serves as surgeon, pathologist, and reconstructive surgeon. It relies on the accuracy of a microscope to trace and ensure removal of skin cancer down to its roots. This procedure allows dermatologists trained in Mohs Surgery to see beyond the visible disease and to precisely identify and remove the entire tumor, leaving healthy tissue unharmed. This procedure is most often used in treating two of the most common forms of skin cancer: basal cell carcinoma and squamous cell carcinoma. The cure rate for Mohs Micrographic Surgery is the highest of all treatments for skin cancer--up to 99 percent even if other forms of treatment have failed. This procedure, the most exact and precise method of tumor removal, minimizes the chance of regrowth and lessens the potential for scarring or disfigurement
Author: Ali Hendi
Publisher: Springer Science & Business Media
ISBN: 3642133991
Category : Medical
Languages : en
Pages : 133
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Book Description
The incidence of skin cancer has risen rapidly in recent decades, and patients often present initially to practitioners in many different specialties. Because skin cancer can vary in clinical appearance, even dermatologists may experience difficulty in reaching a clinical diagnosis. For primary care physicians and physician extenders (physician assistants, nurses, and nurse practitioners), who have had very little or no formal training in dermatology, the task can be still more daunting. In this atlas, the authors set out to provide a practical resource that will help improve the 'visual vocabulary' of physicians and physician extenders, helping them identify lesions that should be biopsied. Hundreds of high-quality color images are included to assist the reader in the task of recognition and identification. All of the common cutaneous malignancies are illustrated, with a number of examples of each entity and of common mimickers. In addition, biopsy techniques and treatment options are presented in step-by step detail with the use of high resolution clinical images, and potential complications of treatment are discussed. This atlas is ideal for all providers who wish to sharpen their clinical acumen and gain confidence in identifying skin cancers.
Author: Thomas P. Habif
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 938
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Book Description
This accurate, profusely illustrated guide to the diagnosis and treatment of skin abnormalities and diseases covers various topical therapies as well as specific skin diseases such as dermatitis, warts, diseases, and tumors. It also details surgical procedures and chemical peels.
Author: Jörg Reichrath
Publisher: Springer Nature
ISBN: 3030462277
Category : Medical
Languages : en
Pages : 422
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Book Description
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Author: Faruque Riffat
Publisher: Springer
ISBN: 8132224973
Category : Medical
Languages : en
Pages : 214
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Book Description
Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.
Author: Lester Davids
Publisher: BoD – Books on Demand
ISBN: 9535109766
Category : Medical
Languages : en
Pages : 388
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Book Description
The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.
Author: David Hill
Publisher: Springer Science & Business Media
ISBN: 9401705119
Category : Medical
Languages : en
Pages : 332
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Book Description
Our series Cancer Prevention - Cancer Control continues to address the causes and prevention of cancer. In this volume, Hill, Elwood, and English bring together a rich resource summarizing the state of science underpinning the primary prevention of skin cancer. While skin cancer causes an increasing burden, particularly in populations of European origin, our understanding of the role of sun exposure together with the genetic components of skin cancer continues to grow. Given the emphasis on evidence-based medicine and public health prevention efforts, it is noteworthy that, although we can all access the same evidence base, countries around the world have had remarkably different responses to the application of this knowledge to prevent skin cancer. The outstanding contribution of the Australian public health community to the scientific understanding of skin cancer etiology and the translation of this knowledge into national prevention efforts uniquely positions the editors to compile this volume focused on the primary prevention of skin cancer. In so doing they draw on an international team of authors to present a “state of the science” summary of skin cancer prevention and to identify those areas where uncertainty remains. To achieve successful prevention of cancer we must translate our scientific knowledge base into effective prevention programs. This book offers the reader keen insights into the depth of our understanding of etiologic pathways for skin cancer. This etiologic science base is complemented by rigorous prevention science placing emphasis on the social context for effective and sustained prevention efforts.
Author: Centre international de recherche sur le cancer
Publisher: International Agency for Research on Cancer
ISBN: 9789283224402
Category : Medical
Languages : en
Pages : 0
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Book Description
The WHO Classification of Skin Tumours is the 11th volume in the 4th edition of the WHO series on the classification of human tumours. The series (also known as the Blue Books) has long been regarded by pathologists as the gold standard for the diagnosis of tumours, and it is an indispensable guide for the design of evaluations, clinical trials, and studies involving cancer. These authoritative and concise reference books provide an international standard for anyone involved in cancer research or the care of cancer patients. Diagnostic criteria, pathological features, and genetic and other associated molecular alterations are described in a disease-oriented manner. This volume updates the existing ICD-O codes and provides new codes for use in epidemiology and cancer registration. It also provides information on clinical features, pathology, genetics, prognosis, and protective factors for each of the tumour types covered. The editors expect that this volume will be of particular interest to pathologists, oncologists, and dermatologists who manage or research skin tumours. Sections are included on all recognized neoplasms (and their variants) of the skin and its adnexae. Since the previous edition, there have been particularly substantial changes to the classification of melanoma, based on the latest information from genetic and molecular studies.
Author: IARC Working Group on Risk of Skin Cancer and Exposure to Artificial Ultraviolet Light
Publisher: World Health Organization
ISBN:
Category : Medical
Languages : en
Pages : 84
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Book Description
This report represents the views and expert opinions of an IARC Working Group that met in Lyon, France, 27-29 June 2005
