Human Skeletal Muscle MRNA Response to Exercise in the Cold PDF Download
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Author: Robert J. Shute
Publisher:
ISBN: 9781321693461
Category : Adaptation (Physiology)
Languages : en
Pages : 110
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Book Description
Endurance exercise in the cold when coupled with recovery in the cold has been shown to effect the expression of select genes to a greater extent than room temperature exercise and recovery. However, it is not known whether endurance exercise in the cold without recovery in the cold elicits this same gene response. Purpose: To determine mitochondrial related gene expression response to exercise in a cold compared to room temperature environment. Methods: Recreationally trained males (N = 9, age: 25 ± 4 y, height: 179 ± 5 cm, weight: 76.2 ± 8.0 kg, %BF: 13.4 ± 3.3%, VO2peak: 4.39 ± 0.82 L/min) each completed two trials consisting of cycling in a cold (C) or room temperature (RT) environment (7.2 ± 0.2 and 20.1 ± 0.2 °C, respectively) for one hour at 60% of the workload associated with VO2peak followed by 3 hours of room temperature recovery. Muscle biopsies were taken from the vastus lateralis pre-exercise and three hours post-exercise for gene expression analysis. Heart rate (HR) and expired gases were also measured throughout the trials. Results: Exercise V02 was lower in C than N (2.68 ± 0.8, 2.81 ± 5.2 L/min, respectively, p = 0.017). HR was similar during exercise and recovery between C and N. Environmental temperatures (p = 0.238) and V02 (p = 0.924) were not different during recovery. PGC-1&agr; and VEGF increased with exercise (p = 0.001, p = 0.001, respectively) but were not different between trials (p = 0.134 and p = 0.975, respectively). ERR&agr; was lower three hours after exercise in C compared to N (p = 0.033). There was a trend toward MEF2A and NRF-2 being lower in C than N (p = 0.086, p = 0.055) but no effect of exercise (p = 0.786, p = 0.256). NRF-1 and TFAM did not change with exercise (p = 0.281, p = 0.117, respectively) or differ between trials (p = 0.981, p = 0.854, respectively). Conclusion: These results indicate that when exercise is performed in a cold environment, select mRNA associated with mitochondrial biogenesis are altered in a manner that would appear to inhibit mitochondrial biogenesis.
Author: Robert J. Shute
Publisher:
ISBN: 9781321693461
Category : Adaptation (Physiology)
Languages : en
Pages : 110
Get Book Here
Book Description
Endurance exercise in the cold when coupled with recovery in the cold has been shown to effect the expression of select genes to a greater extent than room temperature exercise and recovery. However, it is not known whether endurance exercise in the cold without recovery in the cold elicits this same gene response. Purpose: To determine mitochondrial related gene expression response to exercise in a cold compared to room temperature environment. Methods: Recreationally trained males (N = 9, age: 25 ± 4 y, height: 179 ± 5 cm, weight: 76.2 ± 8.0 kg, %BF: 13.4 ± 3.3%, VO2peak: 4.39 ± 0.82 L/min) each completed two trials consisting of cycling in a cold (C) or room temperature (RT) environment (7.2 ± 0.2 and 20.1 ± 0.2 °C, respectively) for one hour at 60% of the workload associated with VO2peak followed by 3 hours of room temperature recovery. Muscle biopsies were taken from the vastus lateralis pre-exercise and three hours post-exercise for gene expression analysis. Heart rate (HR) and expired gases were also measured throughout the trials. Results: Exercise V02 was lower in C than N (2.68 ± 0.8, 2.81 ± 5.2 L/min, respectively, p = 0.017). HR was similar during exercise and recovery between C and N. Environmental temperatures (p = 0.238) and V02 (p = 0.924) were not different during recovery. PGC-1&agr; and VEGF increased with exercise (p = 0.001, p = 0.001, respectively) but were not different between trials (p = 0.134 and p = 0.975, respectively). ERR&agr; was lower three hours after exercise in C compared to N (p = 0.033). There was a trend toward MEF2A and NRF-2 being lower in C than N (p = 0.086, p = 0.055) but no effect of exercise (p = 0.786, p = 0.256). NRF-1 and TFAM did not change with exercise (p = 0.281, p = 0.117, respectively) or differ between trials (p = 0.981, p = 0.854, respectively). Conclusion: These results indicate that when exercise is performed in a cold environment, select mRNA associated with mitochondrial biogenesis are altered in a manner that would appear to inhibit mitochondrial biogenesis.
Author: Bruce Spiegelman
Publisher: Springer
ISBN: 3319727907
Category : Science
Languages : en
Pages : 108
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Book Description
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Gunnar Borg
Publisher:
ISBN: 9780317593631
Category : Psychophysics
Languages : en
Pages : 26
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Book Description
Author: Nicolas J. Pillon
Publisher: Frontiers Media SA
ISBN: 2889669211
Category : Science
Languages : en
Pages : 231
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Book Description
Author: James W. Bellew
Publisher: F.A. Davis
ISBN: 1719647666
Category : Medical
Languages : en
Pages : 1242
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Book Description
A volume in the Contemporary Perspectives in Rehabilitation Series, curated by Steven L. Wolf, PhD, PT, FAPTA Implement a current, evidence-based approach to the selection, application, and uses of therapeutic modalities as an essential tool for functionally based rehabilitation and as a complement to other types of interventions in a patient-centered model of care. The 7th Edition of this groundbreaking text fosters an in-depth understanding of the science behind each modality, its advantages and limitations, its appropriateness for specific conditions, and its implementation. A hands-on problem-solving approach promotes the development of essential clinical decision-making skills through a wealth of full-color photographs and illustrations, special features, and challenging cases studies. See what students and practitioners are saying about the previous edition… Recommend this book. “Great clinical reference for young therapists and seasoned therapists alike. Great information in a nicely organized book.”—Jane D., Online Reviewer Excellent book “Excellent content. Therapeutic modalities and many more... including spinal decompression devices.”—Online Reviewer
Author: Bente Klarlund Pedersen
Publisher:
ISBN: 9781570594205
Category : Exercise
Languages : en
Pages : 206
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Book Description
Author: Adam P Sharples
Publisher: Routledge
ISBN: 1351617001
Category : Science
Languages : en
Pages : 549
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Book Description
Fully revised and expanded, the second edition of Molecular Exercise Physiology offers a student-friendly introduction. It introduces a history documenting the emergence of molecular biology techniques to investigate exercise physiology, the methodology used, exercise genetics and epigenetics, and the molecular mechanisms that lead to adaptation after different types of exercise, with explicit links to outcomes in sport performance, nutrition, physical activity and clinical exercise. Structured around key topics in sport and exercise science and featuring contributions from pioneering scientists, such as Nobel Prize winners, this edition includes new chapters based on cutting-edge research in epigenetics and muscle memory, satellite cells, exercise in cancer, at altitude, and in hot and cold climates. Chapters include learning objectives, structured guides to further reading, review questions, overviews of work by key researchers and box discussions from important pioneers in the field, making it a complete resource for any molecular exercise physiology course. The book includes cell and molecular biology laboratory methods for dissertation and research projects in molecular exercise physiology and muscle physiology. This book is essential reading for upper-level undergraduate or postgraduate courses in cellular and molecular exercise physiology and muscle physiology. It is a valuable resource for any student with an advanced interest in exercise physiology in both sport performance and clinical settings.
Author: Wilfred A. Nix
Publisher: Springer Science & Business Media
ISBN: 3642713378
Category : Medical
Languages : en
Pages : 149
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Book Description
In many cases of neuromuscular disorders the physician is faced with a complete lack of therapeutic approaches. This helplessness places the doctor in a position of conflict between his desire to help and his awareness that there is no treatment. In this situation it is tempting to indiscriminately use any procedure that avoids an admission of medical helplessness while satisfying the patient's demand for treatment. Electrical interventions are often used to avoid this situation. Due to the random use of therapeutic approaches it is not known what really happens. Presumptions and biased empirical observations have led to the exten sive use of different forms of electrical stimulation regimes in neuromuscular diseases. Due to this unsatisfactory situation it is necessary to know more about appropriate methods that are being used in particular disorders. The search for a better understanding of nerve-muscle interaction has shown that certain activity patterns can influence muscle. These experi mental results provide a rational basis for a possible therapeutic use of electrical stimulation of nerve and muscle. Previously most research has been conducted in normal tissue, and little is known regarding the re sponses of diseased muscle. In an interdisciplinary approach to this, it is our intention to present the current knowledge about basic principles of electrical stimulation in normal muscle. Before electrical stimulation can be accepted as a therapeutic tool, we felt it necessary to summarize the effects of activity in normal and diseased muscle and nerve.
Author: Nikos C. Apostolopoulos
Publisher: Springer
ISBN: 3319968009
Category : Science
Languages : en
Pages : 239
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Book Description
In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.
