Lead Toxicity

Lead Toxicity PDF Author: Sarah E. Royce
Publisher:
ISBN:
Category : Lead
Languages : en
Pages : 60

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Book Description

Lead Toxicity

Lead Toxicity PDF Author: Sarah E. Royce
Publisher:
ISBN:
Category : Lead
Languages : en
Pages : 60

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Book Description


Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations

Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 030904927X
Category : Science
Languages : en
Pages : 356

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Book Description
Lead is a ubiquitous toxic agent that is especially damaging to the young child and the developing fetus. Unlike many environmental health risks, the risks associated with lead are no longer theoretical but have been observed for many years. Indeed, the first regulation of lead in paint was enacted in the 1920s. Currently, because of growing evidence of lead toxicity at lower concentrations, the U.S. Centers for Disease Control and Prevention recently lowered its lead-exposure guideline to 10 ug/dl lead in blood from 25 ug/dl. Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations addresses the public health concern about the logistics and feasibility of lead screening in infants and children at such low concentrations. This book will serve as the basis for all U.S. Public Health Service activities and for all state and local programs in monitoring lead.

Lead: Its Effects on Environment and Health

Lead: Its Effects on Environment and Health PDF Author: Astrid Sigel
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311043301X
Category : Science
Languages : en
Pages : 633

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Book Description
Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Potential Health Risks to DOD Firing-Range Personnel from Recurrent Lead Exposure

Potential Health Risks to DOD Firing-Range Personnel from Recurrent Lead Exposure PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309267366
Category : Medical
Languages : en
Pages : 199

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Book Description
Lead is a ubiquitous metal in the environment, and its adverse effects on human health are well documented. Lead interacts at multiple cellular sites and can alter protein function in part through binding to amino acid sulfhydryl and carboxyl groups on a wide variety of structural and functional proteins. In addition, lead mimics calcium and other divalent cations, and it induces the increased production of cytotoxic reactive oxygen species. Adverse effects associated with lead exposure can be observed in multiple body systems, including the nervous, cardiovascular, renal, hematologic, immunologic, and reproductive systems. Lead exposure is also known to induce adverse developmental effects in utero and in the developing neonate. Lead poses an occupational health hazard, and the Occupational Safety and Health Administration (OSHA) developed a lead standard for general industry that regulates many workplace exposures to this metal. The standard was promulgated in 1978 and encompasses several approaches for reducing exposure to lead, including the establishment of a permissible exposure limit (PEL) of 50 μg/m3 in air (an 8-hour time-weighted average [TWA]), exposure guidelines for instituting medical surveillance, guidelines for removal from and return to work, and other risk-management strategies. An action level of 30 μg/m3 (an 8-hour TWA) for lead was established to trigger medical surveillance in employees exposed above that level for more than 30 days per year. Another provision is that any employee who has a blood lead level (BLL) of 60 μg/dL or higher or three consecutive BLLs averaging 50 μg/dL or higher must be removed from work involving lead exposure. An employee may resume work associated with lead exposure only after two BLLs are lower than 40 μg/dL. Thus, maintaining BLLs lower than 40 μg/dL was judged by OSHA to protect workers from adverse health effects. The OSHA standard also includes a recommendation that BLLs of workers who are planning a pregnancy be under 30μg/dL. In light of knowledge about the hazards posed by occupational lead exposure, the Department of Defense (DOD) asked the National Research Council to evaluate potential health risks from recurrent lead exposure of firing-range personnel. Specifically, DOD asked the National Research Council to determine whether current exposure standards for lead on DOD firing ranges protect its workers adequately.The committee also considered measures of cumulative lead dose. Potential Health Risks to DOD Firing-Range Personnel from Recurrent Lead Exposure will help to inform decisions about setting new air exposure limits for lead on firing ranges, about whether to implement limits for surface contamination, and about how to design lead-surveillance programs for range personnel appropriately.

Brush with Death

Brush with Death PDF Author: Christian Warren
Publisher: JHU Press
ISBN: 9780801868207
Category : History
Languages : en
Pages : 384

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Book Description
Winner of the Arthur Viseltear Award for Outstanding Book in the History of Public Health from the American Public Health AssociationSelected by Choice Magazine as an Outstanding Academic Title During the twentieth century, lead poisoning killed thousands of workers and children in the United States. Thousands who survived lead poisoning were left physically crippled or were robbed of mental faculties and years of life. In Brush with Death, social historian Christian Warren offers the first comprehensive history of lead poisoning in the United States. Focusing on lead paint and leaded gasoline, Warren distinguishes three primary modes of exposure—occupational, pediatric, and environmental. This threefold perspective permits a nuanced exploration of the regulatory mechanisms, medical technologies, and epidemiological tools that arose in response to lead poisoning. Today, many children undergo aggressive "deleading" treatments when their blood-lead levels are well below the average blood-lead levels found in urban children in the 1950s. Warren links the repeated redefinition of lead poisoning to changing attitudes toward health, safety, and risk. The same changes that transformed the social construction of lead poisoning also transformed medicine and health care, giving rise to modern environmentalism and fundamentally altered jurisprudence.

Environmental Toxicants

Environmental Toxicants PDF Author: Morton Lippmann
Publisher: John Wiley & Sons
ISBN: 0470442883
Category : Science
Languages : en
Pages : 1189

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Book Description
Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Lead Toxicity

Lead Toxicity PDF Author: Radhey Lal Singhal
Publisher: Urban & Schwarzenberg
ISBN:
Category : Lead
Languages : en
Pages : 536

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Toxicological Profile for Lead

Toxicological Profile for Lead PDF Author:
Publisher:
ISBN:
Category : Lead
Languages : en
Pages : 584

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Protect Your Family from Lead in Your Home

Protect Your Family from Lead in Your Home PDF Author:
Publisher:
ISBN:
Category : Lead
Languages : en
Pages : 16

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Book Description


Superfund and Mining Megasites

Superfund and Mining Megasites PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309097142
Category : Political Science
Languages : en
Pages : 505

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Book Description
For more than 100 years, the Coeur d' Alene River Basin has been known as "The Silver Valley" for being one of the most productive silver, lead, and zinc mining areas in the United States. Over time, high levels of metals (including lead, arsenic, cadmium, and zinc) were discovered in the local environment and elevated blood lead levels were found in children in communities near the metal-refining and smelter complex. In 1983, the U.S. Environmental Protection Agency (EPA) listed a 21-square mile mining area in northern Idaho as a Superfund site. EPA extended those boundaries in 1998 to include areas throughout the 1500-square mile area Coeur d'Alene River Basin project area. Under Superfund, EPA has developed a plan to clean up the contaminated area that will cost an estimated $359 million over 3 decades-and this effort is only the first step in the cleanup process. Superfund and Mining Megasites: Lessons from Coeur d'Alene River Basin evaluates the issues and concerns that have been raised regarding EPA's decisions about cleaning up the area. The scientific and technical practices used by EPA to make decisions about human health risks at the Coeur d'Alene River Basin Superfund site are generally sound; however, there are substantial concerns regarding environmental protection decisions, particularly dealing with the effectiveness of long-term plans.