Human IgG Fc Receptors PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Human IgG Fc Receptors PDF full book. Access full book title Human IgG Fc Receptors by Jan G. J. van de Winkel. Download full books in PDF and EPUB format.
Author: Jan G. J. van de Winkel
Publisher:
ISBN: 9783540607830
Category :
Languages : en
Pages : 241
Get Book Here
Book Description
This book provides a state-of-the-art overview of human IgG Fc receptors, which have a crucial coordinating role in immunity. The organization of the book is unique in that it describes the FcgR on the basis of the cells expressing them. This optimally allows to address specific roles for FcgR on select cells (i.e. immunoregulation on B cells, IgG-transport in placenta, phagocytosis on neutrophils). The information in this book is easily accessible and should be helpful for researchers as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research. Importantly, a summary of key information of the various FcgR is presented in "FcgR Yellow Pages," for rapid/convenient access of relevant data.
Author: Jan G. J. van de Winkel
Publisher:
ISBN: 9783540607830
Category :
Languages : en
Pages : 241
Get Book Here
Book Description
This book provides a state-of-the-art overview of human IgG Fc receptors, which have a crucial coordinating role in immunity. The organization of the book is unique in that it describes the FcgR on the basis of the cells expressing them. This optimally allows to address specific roles for FcgR on select cells (i.e. immunoregulation on B cells, IgG-transport in placenta, phagocytosis on neutrophils). The information in this book is easily accessible and should be helpful for researchers as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research. Importantly, a summary of key information of the various FcgR is presented in "FcgR Yellow Pages," for rapid/convenient access of relevant data.
Author: David V. Erbe
Publisher:
ISBN:
Category : Immunoglobulin G.
Languages : en
Pages : 238
Get Book Here
Book Description
Author: Diane L. Maresco
Publisher:
ISBN:
Category :
Languages : en
Pages : 330
Get Book Here
Book Description
Author: Theo Rispens
Publisher: Elsevier Inc. Chapters
ISBN: 0128060301
Category : Medical
Languages : en
Pages : 46
Get Book Here
Book Description
Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be further subdivided in subclasses. The four subclasses of IgG were discovered in the 1960s following extensive studies using specific rabbit antisera against human IgG myeloma proteins.1 They are designated IgG1, IgG2, IgG3, and IgG4, in order of decreasing abundance. Several decades of research has revealed subtle but profound differences among the subclasses. Each subclass has a unique profile with respect to antigen binding, immune complex formation, complement activation, triggering of effector cells, and placental transport (Table 9.1). In addition, IgG antibody responses to different types of antigens or pathogens often lead to marked skewing toward one of the subclasses. On the other hand, selective subclass deficiencies are usually not detrimental to the individual but do sometimes lead to enhanced susceptibility toward specific classes of pathogens. All in all, the acquired variability within the Ig locus seems to have been selected for beneficial changes during evolution for optimizing or fine-tuning the antibody-mediated immune response.
Author: Bernadette Maree Scott
Publisher:
ISBN:
Category : Fc receptors
Languages : en
Pages : 542
Get Book Here
Book Description
Author: Lynn Patricia Grattage
Publisher:
ISBN:
Category : Fc receptors
Languages : en
Pages : 348
Get Book Here
Book Description
Author: Margaret Ackerman
Publisher: Academic Press
ISBN: 0123948185
Category : Medical
Languages : en
Pages : 376
Get Book Here
Book Description
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system
Author: Farouk Shakib
Publisher: Elsevier
ISBN: 1483287203
Category : Medical
Languages : en
Pages : 321
Get Book Here
Book Description
This book features contributions from internationally renowned scientists from Europe and the USA covering aspects of immunoglobulin subclasses from a molecular and mechanistic approach. The first section presents a detailed discussion of the molecular structure and segmental flexibility of IgG subclasses, including how this controls their effector function. Structure-function relationships are fully developed in the second section by means of a functional approach to the study of complement activation and opsonization by IgG subclasses. The final section contains a generous account of the regulation of IgG subclass expressions.
Author: Marije B. Overdijk
Publisher: Elsevier Inc. Chapters
ISBN: 0128060344
Category : Medical
Languages : en
Pages : 36
Get Book Here
Book Description
Historically, lack of specificity for cancer cells has been a major problem in cancer treatment; however, the development of monoclonal antibodies (mAbs), which combine high specificity with multiple mechanisms of action (MoAs), started a revolution in anti-cancer treatment options which continues to date. As of January 2013, 15 major antibody products were being marketed for cancer treatment in various countries around the globe, 10 of which are unmodified mAbs, which generally have multiple potential MoAs and may act via direct, Fab-domain-related effects or indirect, Fc-domain-related effects. Fc-domain-related effects consist of immune-mediated effector functions, which include complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP). ADCC and ADCP depend on the engagement of Fcγ-receptors (FcγR) on immune effector cells by Fc-domains clustered due to antibody–antigen binding. Similarly, CDC depends on the engagement of proteins of the complement system by clustered antibody Fc domains. In this chapter, preclinical and clinical studies with approved anti-cancer mAbs are reviewed, with an emphasis on the role of FcγR-mediated effector functions. The importance of therapeutic antibody–FcγR interactions for human treatment can be deduced from correlations of clinical responses with FcγR polymorphisms, results supported by a wealth of preclinical and in vitro studies.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Get Book Here
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
