How Selegiline ((-)-Deprenyl) Slows Brain Aging PDF Download
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Author: Joseph Knoll
Publisher: Bentham Science Publishers
ISBN: 1608054705
Category : Medical
Languages : en
Pages : 161
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Book Description
This e-book is a reference on Selegiline ((-)-Deprenyl) effects on the brain. Selegiline, described in thousands of research papers, is registered in over 60 countries. At present, more than one hundred preparations containing selegiline circulate in the global market under different brand names. They are widely used in the treatment of Parkinson's disease, Alzheimer's disease, major depression and as a geroprotective / anti-aging drug. ((-)-Deprenyl) selegiline, the first selective inhibitor of B-type MAO which, in contrast to the known MAO inhibitors, did not potentiate the effect of tyramine but inhibited it. the compound could be combined with levodopa in Parkinson's disease without signs of hypertensive reactions. the DATATOP study in the USA revealed that (-)-deprenyl delayed the onset of disability associated with early, otherwise untreated Parkinson's disease. the age-related decay of the supply of the brain with phenylethylamine (PEA), due to the progressive increase of MAO-B activity in the aging brain, and dopamine, due to the better than average decline of the dopaminergic neuronal activity during the postdevelopmental phase of life, are irresistible biochemical lesions of aging. the speed of deterioration of behavioral performances with the passing of time and longevity depends significantly on the pace of the worsening of these lesions. (-)-Deprenyl, increasing the supply of the brain with PEA and dopamine, counteracts this aging process. Maintenance of male rats from sexual maturity until death on ((-)-deprenyl) delays the age-related loss of the capacity to ejaculate, slows the age-related decline of learning ability and prolongs life. In humans, maintenance from sexual maturity on (-)-deprenyl (1 mg daily) is, for the time being, the most promising prophylactic treatment to fight against the age-related decay of behavioral performances, prolonging life, and preventing or delaying the onset of age-related neurodegenerative diseases such as Parkinson's and Alzheimer's. This e-book is a useful reference for graduate medical students, academic researchers in the field of neuropsychopharmacology, neurophysiology and gerontology and professional research groups in commercial organizations manufacturing selegiline preparations.
Author: Joseph Knoll
Publisher: Bentham Science Publishers
ISBN: 1608054705
Category : Medical
Languages : en
Pages : 161
Get Book Here
Book Description
This e-book is a reference on Selegiline ((-)-Deprenyl) effects on the brain. Selegiline, described in thousands of research papers, is registered in over 60 countries. At present, more than one hundred preparations containing selegiline circulate in the global market under different brand names. They are widely used in the treatment of Parkinson's disease, Alzheimer's disease, major depression and as a geroprotective / anti-aging drug. ((-)-Deprenyl) selegiline, the first selective inhibitor of B-type MAO which, in contrast to the known MAO inhibitors, did not potentiate the effect of tyramine but inhibited it. the compound could be combined with levodopa in Parkinson's disease without signs of hypertensive reactions. the DATATOP study in the USA revealed that (-)-deprenyl delayed the onset of disability associated with early, otherwise untreated Parkinson's disease. the age-related decay of the supply of the brain with phenylethylamine (PEA), due to the progressive increase of MAO-B activity in the aging brain, and dopamine, due to the better than average decline of the dopaminergic neuronal activity during the postdevelopmental phase of life, are irresistible biochemical lesions of aging. the speed of deterioration of behavioral performances with the passing of time and longevity depends significantly on the pace of the worsening of these lesions. (-)-Deprenyl, increasing the supply of the brain with PEA and dopamine, counteracts this aging process. Maintenance of male rats from sexual maturity until death on ((-)-deprenyl) delays the age-related loss of the capacity to ejaculate, slows the age-related decline of learning ability and prolongs life. In humans, maintenance from sexual maturity on (-)-deprenyl (1 mg daily) is, for the time being, the most promising prophylactic treatment to fight against the age-related decay of behavioral performances, prolonging life, and preventing or delaying the onset of age-related neurodegenerative diseases such as Parkinson's and Alzheimer's. This e-book is a useful reference for graduate medical students, academic researchers in the field of neuropsychopharmacology, neurophysiology and gerontology and professional research groups in commercial organizations manufacturing selegiline preparations.
Author: Abhilash K. Desai
Publisher: Elsevier Health Sciences
ISBN: 1455700320
Category : Medical
Languages : en
Pages : 180
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Book Description
This issue examines what is a healthy aging brain and covers preventive measures for succesful cognitive aging. Topics covered include: A road map to healthy aging brain; Cardiovascular risk factors, cerebrovascular disease burden and healthy aging brain; Healthy aging brain: Impact of head injury, alcohol and environmental toxins; Healthy aging brain: What has sleep go to do with it?; Endocrine aspects of healthy aging brain; Healthy aging brain: Role of exercise and physically active lifestyle; Healthy aging brain: Role of nutrition and nutritional supplements; Healthy aging brain: Role of cognitive reserve, cognitive stimulation and cognitive exercises; Healthy aging brain: Impact of positive and negative emotions; Dementia risk predictor. Are we there yet?; Potential future neuroprotective therapies for neurodegenerative disorders and stroke; Healthy aging brain: Importance of promoting resilience and creativity.
Author: Y.L. Wright M.A.
Publisher: Lulu.com
ISBN: 0359071309
Category : Health & Fitness
Languages : en
Pages : 276
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Book Description
Get Smart with KETO SMART! Heal your brain and heal your body with this easy KETO SMART program. KETO SMART is packed with secrets to improve your memory and thinking with simple instructions that you can easily follow. Learn how to radically improve the health of your brain, so that you can enjoy life to the max at any age. Your heart, arteries, and everything else will improve as well. The KETO SMART 10-step protocol is MUCH more than just following a ketogenic diet. The KETO SMART 10-step protocol is a comprehensive program of self-healing. Follow the KETO SMART ten easy action steps, and soon your thinking mind will become as penetrating as the depths of a pristine alpine lake on a quiet sunny morning. The goal of this book is to guide you through the maze of interconnected problems. Every step helps, but you only get the gold ring of health by following the complete treatment plan. It isnÕt hard if you know what to do. It is impossible if you don't.
Author: Frank J. Ayd
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781724685
Category : Medical
Languages : en
Pages : 1138
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Book Description
Now in its thoroughly updated Second Edition, Dr. Ayd's highly acclaimed Lexicon is an indispensable desk reference for anyone working in psychiatry, neurology, or the underlying basic neurosciences. It provides succinct, detailed, and easily accessible definitions for the entire range of terms currently used in these fields, including drug categories, receptors, and the sites and mechanisms affected by pharmacologic treatments. This edition reflects the most recent developments in genetics and in psychopharmacology, including new drugs and current concepts on drug-drug interactions. Dr. Ayd has added over 1,000 new terms and rewritten nearly half of the entries in the original edition. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Author: Dr. Hiroshi Demura
Publisher: iUniverse
ISBN: 1450255760
Category : Health & Fitness
Languages : en
Pages : 376
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Book Description
As we grow older, many of us experience a tremendous amount of frustration because something inside us doesnt work the way it used to. Nutrition experts tell us to eat certain kinds of food some claim free radicals are the sole cause of aging, and that the only way to longevity is through antioxidant supplements. Fitness gurus tell us the only answer is exercise. When we do exercise or go on a diet, we feel a little betterbut not much, and not the way we felt when we were younger. We exercise or diet twice as much to stay at the same place, and even that is a challenge. The story has been the same throughout history, so we wonder if we should continue to fight the battle, or if we should just learn to grow old gracefully. Improvements in medical technology and new knowledge about exercise, nutrition, and rest are all part of the solution to remaining young and healthy. However, we continue to see some people who do not take particularly good care of themselves, yet are aging more gentlyand we know instinctively that parts of the anti-aging puzzle must still be missing.
Author: Richard P. Brown
Publisher: W. W. Norton & Company
ISBN: 0393707695
Category : Medical
Languages : en
Pages : 465
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Book Description
All you need to know about herbs, nutrients, and yoga for enhancing mental health. Many physicians and therapists agree that herbs and mind-body practices enhance health, but many more are reluctant to integrate them into their clinical work because of a lack of training or, given how long it takes to master the use of hundreds of different herbs, a lack of time. But the trend is clear: clients and consumers alike want control over their health care choices, making the time ripe for a practical resource that guides both the clinician and the consumer on complementary and alternative medicine (CAM). This book answers that call. Three noted experts in integrative medicine, Drs. Brown, Gerbarg, and Muskin, demystify the complexities of alternative mental health care, giving readers a comprehensive yet accessible guidebook to the best treatment options out there. From mood, memory, and anxiety disorders to ADD, sexual enhancement issues, psychotic disorders, and substance abuse, every chapter covers a major diagnostic category. The authors then present a range of complementary and alternative treatments-including the use of herbs, nutrients, vitamins, nootropics, hormones, and mind-body practices- that they have found to be beneficial for various conditions within each category. For example, B complex vitamins and folate have been shown to help with depression; omega-3 fatty acids can offer relief for bipolar sufferers; coherent and resonant breathing techniques-used by Buddhist monks-induce healthy alpha rhythms in the brain to relieve anxiety; the elderly can boost their memory by taking the ancient medicinal herb Rhodiola rosea; and those with chronic fatigue syndrome can find comfort in acupuncture and yoga. Focusing on evidence-based approaches, the research, the authors' clinical experience, and the potential risks and benefits of each treatment are carefully examined. Brown, Gerbarg, and Muskin have distilled an otherwise daunting field of treatment down to its basics: their overriding approach is to present the CAM methods that are most practical in a clinical setting, easy to administer, and low in side effects. With helpful summary tables at the end of each chapter, clinical pearls, and case vignettes interspersed throughout, this is a must-have resource for all clinicians and consumers who want the best that alternative medicine has to offer.
Author: James F. Willott, PhD
Publisher: Springer Publishing Company
ISBN: 0826117171
Category : Medical
Languages : en
Pages : 389
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Book Description
Neurogerontology tells the story of how the aging brain affects all aspects of cognition and physical performance. It comprehensively links the principles and substance of neuroscience with gerontology and psychology. Written largely from a behavioral neuroscience perspective, Neurogerontology explores the functional relationships between the central nervous system and psychological phenomena of aging, including perception, arousal, learning, cognition, and motor behavior. Willot emphasizes healthy aging, but dementia and other pathological conditions are discussed when relevant. This evidence-based approach to the neuroscience of aging makes this a valuable reference for professionals, as well as an informative textbook for students in gerontology courses.
Author: M.-F. Schulz-Aellen
Publisher: Springer Science & Business Media
ISBN: 1461220068
Category : Science
Languages : en
Pages : 291
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Book Description
The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.
Author: Beverly A. Potter
Publisher: Ronin Publishing
ISBN: 1579511120
Category : Health & Fitness
Languages : en
Pages : 151
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Book Description
As a group, baby boomers are heading rapidly into their "golden years," and there's little doubt that they won't go lightly. But is the process really irrevocable and irreversible? With more financial resources than any other demographic, and the knowledge gained simply by living, boomers are in the best position to at least delay the aging process. This practical guide offers a wealth of ways to do that. Dr. Beverly Potter, who has written numerous books on enhancing one's lifestyle, includes but goes beyond anti-aging and life extension. Youthfulness, she says, is characterized by vigor, flexibility, bounciness, good health, physical shapeliness, beauty, curiosity, and mental acuity — all of which can be achieved through the regimens the book describes. Potter takes a multifaceted approach, incorporating both current science and proven techniques into a program that stresses vitamins, nutrients, healthful foods, and supplements; activities and lifestyles; ways of thinking; sexual techniques; brain fitness training; and more.
Author: Abraham N. Lieberman
Publisher: Simon and Schuster
ISBN: 0671768190
Category : Health & Fitness
Languages : en
Pages : 276
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Book Description
A guide for Parkinson patients and their caregivers that addresses the body and the spirit.
