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Author: Xuexian Yang
Publisher: Frontiers Media SA
ISBN: 283254973X
Category : Medical
Languages : en
Pages : 144
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Book Description
Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived "masking" molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases.
Author: Xuexian Yang
Publisher: Frontiers Media SA
ISBN: 283254973X
Category : Medical
Languages : en
Pages : 144
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Book Description
Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived "masking" molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases.
Author: Gert Flik
Publisher: Garland Science
ISBN: 0203487702
Category : Science
Languages : en
Pages : 256
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Book Description
This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field.
Author: K.-P. Chang
Publisher: Springer Science & Business Media
ISBN: 3642728405
Category : Science
Languages : en
Pages : 426
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Book Description
Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128014334
Category : Science
Languages : en
Pages : 392
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Book Description
The theme of this volume is to discuss Eco-evolutionary Dynamics. Updates and informs the reader on the latest research findings Written by leading experts in the field Highlights areas for future investigation
Author: Gianni Marone
Publisher: Academic Press
ISBN: 0080535852
Category : Medical
Languages : en
Pages : 738
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Book Description
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Author: Nancy Guillen
Publisher: Springer Nature
ISBN: 3030448266
Category : Medical
Languages : en
Pages : 368
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Book Description
Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.
Author: Mukesh Samant
Publisher: Academic Press
ISBN: 0128227982
Category : Medical
Languages : en
Pages : 281
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Book Description
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment Discusses novel approaches to study parasite infection and treatment Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
Author: Pablo Muriel
Publisher: Academic Press
ISBN: 0128043210
Category : Science
Languages : en
Pages : 917
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Book Description
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
Author: Toni Aebischer
Publisher: Frontiers Media SA
ISBN: 2889454851
Category :
Languages : en
Pages : 294
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Book Description
Eukaryotic parasites (including parasitic protozoans, worms and arthropods) are more complex and heterogeneous organisms than pathogenic bacteria and viruses. This notion implies different evolutionary strategies of host exploitation. Typically, parasites establish long-term infections and induce relatively little mortality, as they often limit pathological changes by modulating host cells and downregulating adverse immune responses. Their pattern of distribution tends to be endemic rather than epidemic. Despite these seemingly benign traits, parasites usually cause substantial chronic morbidity, thus constituting an enormous socioeconomic burden in humans, particularly in resource poor countries, and in livestock worldwide. Parasite-induced fitness costs are an evolutionary force that can shape populations and contribute to species diversity. Therefore, a thorough understanding of parasites and parasitic diseases requires detailed knowledge of the respective biochemical, molecular and immunological aspects as well as of population genetics, epidemiology and ecology. This Research Topic (RT) bridges disciplines to connect molecular, immunological and wildlife aspects of parasitic infections. The RT puts emphases on four groups of parasites: Plasmodium, Toxoplasma, Giardia and intestinal helminths. Co-infections are also covered by the RT as they represent the most common form of parasite infections in wildlife and domestic animal populations. Within the four types of parasites the following topics are addressed: (1) Experimental models: hypothesis testing, translation and limits. (2) Critical appraisal of experimental models. (3) Natural systems: Technological advances for investigations in natural parasite-host systems and studies in natural systems. (4) The urgent need for better models and methods in natural parasite systems. Hence, the RT covers and illustrate by the means of four main parasitic infections the parasite-host system at the molecular, cellular and organismic level.