Hormonal Regulation of Estrogen and Progesterone Receptors in Mouse Mammary Glands in Vivo PDF Download
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Author: Yuqian Zhou
Publisher:
ISBN:
Category :
Languages : en
Pages : 456
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Author: Yuqian Zhou
Publisher:
ISBN:
Category :
Languages : en
Pages : 456
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Author: Mark Douglas Aupperlee
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 396
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Author: Benjamin S. Leung
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 312
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Author: Benjamin S. Leung
Publisher: Springer London
ISBN:
Category : Medical
Languages : en
Pages : 328
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 46
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Both the growth and the development of the mammary gland are controlled by the female hormones estrogen and progesterone, and by interactions between the epithelial and stromal compartments of the breast. Changes in the regulation of any of these processes may lead to breast cancer. Therefore, we need to understand in detail the mechanisms that control proliferation and development of the mammary gland. We have investigated the role of progesterone in the process of sidebranching and alveologenesis In the mammary gland using mice laclting the progesterone receptor which are defective in these processes. By reconstituting murine mammary glands in vivo, we have shown that the progesterone receptor is required only in epithelial cells for proper sidebranching to occur. Our studies suggest that progesterone acts in a paracrine manner and more recent data suggests that Wnt-4 is a possible mediator of this paracrine effect. In parallel studies, we have observed that breast cancer cells can dramatically downregulate the expression of hepatocyte growth factor in cocultured libroblasts. These results suggest an important role of paracrine interactions also in breast cancer development. In addition, we have characterized the role of the estrogen receptor in regulating the proliferation of breast cancer cells. We postulate that the ability of estrogen receptor to control cyclin Dl expression and proliferation of breast cancer cells may be acquired during breast cancer development. In conclusion, we have studied the role of female hormones and stroma-epithelial interactions in regulating mammary gland development and tumorigenesis.
Author: Joseph Alexander Cameron
Publisher:
ISBN:
Category : Hormones
Languages : en
Pages : 248
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Author: Emily Elizabeth Flynn
Publisher:
ISBN: 9781124510972
Category : Electronic dissertations
Languages : en
Pages : 299
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Author: Brenda Pauline Alston
Publisher:
ISBN:
Category : Hormones
Languages : en
Pages : 138
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Our previous results have shown that the basement membrane (BM) regulated the expression and function of estrogen receptor-alpha (ERa) in mouse mammary epithelial cells. New results shown here indicate that the presence of lactogenic hormones was required for the regulatory effect of BM on ERa levels. We present evidence that cell adhesion to the BM components collagen-IV, through alpha 2 and beta 1 integrin subunits and laminin-l, through alpha 2, alpha 6 and beta 1 subunits are the relevant interactions responsible for transducing the signal of the BM that increases ERa expression. On the other hand, BM- induced changes in cell proliferation and cell morphology were not involved. Thus, the changes observed in ER expression and estrogenic effect when mammary epithelial cells are removed from the gland and placed in culture could be due to the disruption of the tissue organization and, in particular, to the lack of cell-matrix interactions on tissue culture plastic. Our system model could be useful to better understand the mechanisms involved in the regulation of ER expression and function during mammary gland development and breast tumor progression.
Author: Shiqing Wang
Publisher:
ISBN:
Category : Estrogen
Languages : en
Pages : 268
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