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Author: Alexander Heifetz
Publisher: Springer Nature
ISBN: 1071634496
Category : Science
Languages : en
Pages : 430
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Book Description
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
Author: Alexander Heifetz
Publisher: Springer Nature
ISBN: 1071634496
Category : Science
Languages : en
Pages : 430
Get Book Here
Book Description
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
Author: Alexander Heifetz
Publisher: Humana
ISBN: 9781071634486
Category : Science
Languages : en
Pages : 0
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Book Description
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
Author: Khang, Alex
Publisher: IGI Global
ISBN:
Category : Science
Languages : en
Pages : 510
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Book Description
In a world driven by technology and data, classical computing faces limitations in tackling complex challenges like climate modeling and financial risk assessment. These barriers impede our aspirations to revolutionize industries and solve intricate real-world problems. To bridge this gap, we must embrace quantum computing. Edited by Alex Khang PH, Principles and Applications of Quantum Computing is a transformative solution to this challenge. It delves into the interdisciplinary realms of computer science, physics, and mathematics, unveiling the incredible potential of quantum computing, which outperforms supercomputers by 158 million times. This technology, rooted in quantum mechanics, offers solutions to global problems and opens new frontiers in AI, cybersecurity, finance, drug development, and more. By engaging with this book, you become a pioneer in the quantum revolution, contributing to reshaping the limits of what's achievable in our digital age.
Author:
Publisher: Elsevier
ISBN: 0128114320
Category : Medical
Languages : en
Pages : 3421
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Book Description
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Author: Vladimir Voevodin
Publisher: Springer Nature
ISBN: 3030365921
Category : Computers
Languages : en
Pages : 757
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Book Description
This book constitutes the refereed post-conference proceedings of the 5th Russian Supercomputing Days, RuSCDays 2019, held in Moscow, Russia, in September 2019. The 60 revised full papers presented were carefully reviewed and selected from 127 submissions. The papers are organized in the following topical sections: parallel algorithms; supercomputer simulation; HPC, BigData, AI: architectures, technologies, tools; and distributed and cloud computing.
Author: Cannataro, Mario
Publisher: IGI Global
ISBN: 1605663751
Category : Medical
Languages : en
Pages : 960
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Book Description
"This book provides methodologies and developments of grid technologies applied in different fields of life sciences"--Provided by publisher.
Author: Chao Wang
Publisher: CRC Press
ISBN: 1498784003
Category : Computers
Languages : en
Pages : 287
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Book Description
High-Performance Computing for Big Data: Methodologies and Applications explores emerging high-performance architectures for data-intensive applications, novel efficient analytical strategies to boost data processing, and cutting-edge applications in diverse fields, such as machine learning, life science, neural networks, and neuromorphic engineering. The book is organized into two main sections. The first section covers Big Data architectures, including cloud computing systems, and heterogeneous accelerators. It also covers emerging 3D IC design principles for memory architectures and devices. The second section of the book illustrates emerging and practical applications of Big Data across several domains, including bioinformatics, deep learning, and neuromorphic engineering. Features Covers a wide range of Big Data architectures, including distributed systems like Hadoop/Spark Includes accelerator-based approaches for big data applications such as GPU-based acceleration techniques, and hardware acceleration such as FPGA/CGRA/ASICs Presents emerging memory architectures and devices such as NVM, STT- RAM, 3D IC design principles Describes advanced algorithms for different big data application domains Illustrates novel analytics techniques for Big Data applications, scheduling, mapping, and partitioning methodologies Featuring contributions from leading experts, this book presents state-of-the-art research on the methodologies and applications of high-performance computing for big data applications. About the Editor Dr. Chao Wang is an Associate Professor in the School of Computer Science at the University of Science and Technology of China. He is the Associate Editor of ACM Transactions on Design Automations for Electronics Systems (TODAES), Applied Soft Computing, Microprocessors and Microsystems, IET Computers & Digital Techniques, and International Journal of Electronics. Dr. Chao Wang was the recipient of Youth Innovation Promotion Association, CAS, ACM China Rising Star Honorable Mention (2016), and best IP nomination of DATE 2015. He is now on the CCF Technical Committee on Computer Architecture, CCF Task Force on Formal Methods. He is a Senior Member of IEEE, Senior Member of CCF, and a Senior Member of ACM.
Author: Shailza Singh
Publisher: Springer Nature
ISBN: 9811919534
Category : Science
Languages : en
Pages : 170
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Book Description
This book presents the applications of systems biology and synthetic biology in cancer medicine. It highlights the use of computational and mathematical models to decipher the complexity of cancer heterogeneity. The book emphasizes the modeling approaches for predicting behavior of cancer cells, tissues in context of drug response, and angiogenesis. It introduces cell-based therapies for the treatment of various cancers and reviews the role of neural networks for drug response prediction. Further, it examines the system biology approaches for the identification of medicinal plants in cancer drug discovery. It explores the opportunities for metabolic engineering in the realm of cancer research towards development of new cancer therapies based on metabolically derived targets. Lastly, it discusses the applications of data mining techniques in cancer research. This book is an excellent guide for oncologists and researchers who are involved in the latest cancer research.
Author: Valentina Emilia Balas
Publisher: Academic Press
ISBN: 0128183195
Category : Science
Languages : en
Pages : 320
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Book Description
Handbook of Data Science Approaches for Biomedical Engineering covers the research issues and concepts of biomedical engineering progress and the ways they are aligning with the latest technologies in IoT and big data. In addition, the book includes various real-time/offline medical applications that directly or indirectly rely on medical and information technology. Case studies in the field of medical science, i.e., biomedical engineering, computer science, information security, and interdisciplinary tools, along with modern tools and the technologies used are also included to enhance understanding. Today, the role of Big Data and IoT proves that ninety percent of data currently available has been generated in the last couple of years, with rapid increases happening every day. The reason for this growth is increasing in communication through electronic devices, sensors, web logs, global positioning system (GPS) data, mobile data, IoT, etc. - Provides in-depth information about Biomedical Engineering with Big Data and Internet of Things - Includes technical approaches for solving real-time healthcare problems and practical solutions through case studies in Big Data and Internet of Things - Discusses big data applications for healthcare management, such as predictive analytics and forecasting, big data integration for medical data, algorithms and techniques to speed up the analysis of big medical data, and more
Author: Felipe López-Saucedo
Publisher: Bentham Science Publishers
ISBN: 9815136933
Category : Technology & Engineering
Languages : en
Pages : 279
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Book Description
Synthesis of Nanomaterials is a beginner’s guide to the synthesis and characterization of biomaterials for medical devices and implants. It presents 8 chapters explaining the use of biomaterials in medicine and pharmacology. The concepts are explained with the guidance of specialists who present the principal techniques and methods to obtain high-performance polymers and composite materials. Starting with an introduction to the subject, the book explains nanomaterials synthesis and progresses towards engineering applications. The chapters also cover modern biomaterials such as stimuli-responsive biomaterials, hydrogels, and self-healing materials. One chapter is dedicated to computational and theoretical techniques in biomedicine and a final chapter covering microencapsulation for advanced drug delivery rounds up the contents. Synthesis of Nanomaterials is a primary reference book for undergraduate and graduate students as well as professors involved in multidisciplinary research and teaching programs.
