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Author: Bimal Krishna Banik
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110735776
Category : Science
Languages : en
Pages : 532
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Book Description
Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Author: Bimal Krishna Banik
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110735776
Category : Science
Languages : en
Pages : 532
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Book Description
Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Author: Rajesh Kumar Singh
Publisher: Bentham Science Publishers
ISBN: 9815040081
Category : Medical
Languages : en
Pages : 285
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Book Description
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)
Author: Rajesh Kumar Singh
Publisher: Bentham Science Publishers
ISBN: 9815040057
Category : Medical
Languages : en
Pages : 231
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Book Description
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents
Author: Lesley Ann Stewart
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages :
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Book Description
Author: Xianyong Bu
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 474
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Book Description
Author: Rajesh Kumar Singh
Publisher: Bentham Science Publishers
ISBN: 9789815040098
Category :
Languages : en
Pages : 0
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Book Description
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship (sar) studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an updates (2017-2020)
Author: A. A. R. A. Mal ullah
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Vivek Asati
Publisher: Elsevier
ISBN: 0323996329
Category : Computers
Languages : en
Pages : 504
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Book Description
Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1. The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets. Discusses recently discovered molecular targets for cancer therapy Brings updated literature of heterocyclic compounds, an important construction motif for the development of new anticancer drugs Encompasses comprehensive compilation of recently introduced anticancer drugs in the market and their health outcomes and pharmacoeconomics
Author: Rajesh Kumar Singh
Publisher: Bentham Science Publishers
ISBN: 9789815040067
Category :
Languages : en
Pages : 0
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Book Description
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents
Author: Michael L. Rogers
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 424
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Book Description
A competing reaction in the 2-aryl case led to the isolation of N,N-dimethyl-2-[cis-2-(phenylamino)vinyl]-8-methylquinoline-3-carboxamide. The A and B rings were altered to include additional ring nitrogens and to include an alkoxy moiety. Derivatisation of the carboxamide side-chain was undertaken to incorporate (S)- and (R)-N-[2-(1-dimethylamino)propyl] and (S)-N-[1((dimethylamino)carbonyl)ethyl] carboxamides. The derived carboxamides were assessed for their growth inhibitory properties by the Cancer Research Laboratory, University of Auckland, New Zealand.