Handbook of Systems Biology PDF Download
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Author: Marian Walhout
Publisher: Academic Press
ISBN: 012385945X
Category : Science
Languages : en
Pages : 553
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Book Description
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers
Author: Marian Walhout
Publisher: Academic Press
ISBN: 012385945X
Category : Science
Languages : en
Pages : 553
Get Book Here
Book Description
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers
Author: Michael Stumpf
Publisher: John Wiley & Sons
ISBN: 1119952042
Category : Science
Languages : en
Pages : 624
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Book Description
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
Author: Nicolas Musi
Publisher: Academic Press
ISBN: 0124116205
Category : Medical
Languages : en
Pages : 576
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Book Description
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. - Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition - Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline - Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline - Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering - New chapters on genetics, evolutionary biology, bone aging, and epigenetic control - Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
Author: Srinivas Aluru
Publisher: CRC Press
ISBN: 1420036270
Category : Computers
Languages : en
Pages : 1108
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Book Description
The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of
Author: Limin Angela Liu
Publisher: IGI Global
ISBN: 9781609604912
Category : Computers
Languages : en
Pages : 0
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Book Description
"This book offers information on the state-of-the-art development in the fields of computational biology and systems biology, presenting methods, tools, and applications of these fields by many leading experts around the globe"--Provided by publisher.
Author: James E. Ferrell
Publisher: Garland Science
ISBN: 1000430782
Category : Science
Languages : en
Pages : 410
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Book Description
How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: · Full-color illustration program with diagrams to help illuminate the concepts · Enables the reader to apply modeling and theory to the biological processes · Further Reading for each chapter · High-quality figures available for instructors to download
Author: Robert Splinter
Publisher: CRC Press
ISBN: 142007525X
Category : Science
Languages : en
Pages : 550
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Book Description
In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that a
Author: Kory Floyd
Publisher: Routledge
ISBN: 1351235575
Category : Language Arts & Disciplines
Languages : en
Pages : 525
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Book Description
The Handbook of Communication Science and Biology charts the state of the art in the field, describing relevant areas of communication studies where a biological approach has been successfully applied. The book synthesizes theoretical and empirical development in this area thus far and proposes a roadmap for future research. As the biological approach to understanding communication has grown, one challenge has been the separate evolution of research focused on media use and effects and research focused on interpersonal and organizational communication, often with little intellectual conversation between the two areas. The Handbook of Communication Science and Biology is the only book to bridge the gap between media studies and human communication, spurring new work in both areas of focus. With contributions from the field’s foremost scholars around the globe, this unique book serves as a seminal resource for the training of the current and next generation of communication scientists, and will be of particular interest to media and psychology scholars as well.
Author: Edwin Wang
Publisher: CRC Press
ISBN: 1040189245
Category : Computers
Languages : en
Pages : 622
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Book Description
The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorgenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and their applications in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.
Author: Jose M. Causadias
Publisher: John Wiley & Sons
ISBN: 1119181348
Category : Psychology
Languages : en
Pages : 562
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Book Description
A comprehensive guide to empirical and theoretical research advances in culture and biology interplay Culture and biology are considered as two domains of equal importance and constant coevolution, although they have traditionally been studied in isolation. The Handbook of Culture and Biology is a comprehensive resource that focuses on theory and research in culture and biology interplay. This emerging field centers on how these two processes have evolved together, how culture, biology, and environment influence each other, and how they shape behavior, cognition, and development among humans and animals across multiple levels, types, timeframes, and domains of analysis. The text provides an overview of current empirical and theoretical advances in culture and biology interplay research through the work of some of the most influential scholars in the field. Harnessing insights from a range of disciplines (e.g., biology, neuroscience, primatology, psychology) and research methods (experiments, genetic epidemiology, naturalistic observations, neuroimaging), it explores diverse topics including animal culture, cultural genomics, and neurobiology of cultural experiences. The authors also advance the field by discussing key challenges and limitations in current research. The Handbook of Culture and Biology is an important resource that: Gathers related research areas into the single, cohesive field of culture and biology interplay Offers a unique and comprehensive collection from leading and influential scholars Contains information from a wide range of disciplines and research methods Introduces well-validated and coherently articulated conceptual frameworks Written for scholars in the field, this handbook brings together related areas of research and theory that have traditionally been disjointed into the single, cohesive field of culture and biology interplay.
