Handbook of Membrane Channels PDF Download
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Author:
Publisher: Academic Press
ISBN: 032313890X
Category : Science
Languages : en
Pages : 615
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Book Description
This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.
Author:
Publisher: Academic Press
ISBN: 032313890X
Category : Science
Languages : en
Pages : 615
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Book Description
This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.
Author: Jie Zheng
Publisher: CRC Press
ISBN: 1466551429
Category : Medical
Languages : en
Pages : 682
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Book Description
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Author: Bertil Hille
Publisher: Sinauer Associates, Incorporated
ISBN:
Category : Medical
Languages : en
Pages : 638
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Book Description
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Author: Nikita Gamper
Publisher: Humana Press
ISBN: 9781493960095
Category : Science
Languages : en
Pages : 456
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Book Description
This Methods in Molecular Biology book offers strategies and protocols for studying a large group of proteins that form ionic channels in the plasma membrane and intracellular membranes of cells. Includes step-by-step protocols, materials lists, tips and more."
Author: C. Miller
Publisher: Springer Science & Business Media
ISBN: 1475713614
Category : Science
Languages : en
Pages : 579
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Book Description
It is now over 30 years since the idea of ion-conducting pores burst on the elec trophysiological scene, 15 years since these were generalIy realized to be mem brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial "VDAC," and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possible, with a view towards understanding the molecular mechanisms ofthe protein's behavior and how this is related to the underlying molecular structure. This is always a daunting task, alI the more so with ion channels because of our still primitive and scanty understanding of channel structures and because of the difficulty in iso lating functionally active channel proteins. In this volume, which can be considered a biochemically slanted companion to Sakmann and Neher's Single-Channel Recording, I have tried to present a view of the current landscape of ion-channel reconstitution. These chapters illustrate not only the different approaches and techniques of the major practitioners of ion channel reconstitution but, as importantly, the varied motivations for doing this kind of work.
Author: Paul J. Kammermeier
Publisher:
ISBN: 9781621821205
Category : Ion channels
Languages : en
Pages : 0
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Book Description
The propagation of signals through the nervous system depends on rapid changes in electric potential across cell membranes. These changes are mediated by ion channels--macromolecular pores that facilitate the passage of specific ions (e.g., K+ or Na+) through cell membranes in response to various signals. Defects in ion channels can lead to diseases such as epilepsy. This laboratory manual provides state-of-the-art techniques for investigating ion channel properties and activity, particularly in the nervous system. Contributors present electrophysiological methods to examine single-channel activity in cultured cells, to study synaptic plasticity and circuit dynamics in brain slice preparations, and to perform whole-cell recordings in awake--and even freely moving--animals. The use of optogenetic tools to study synapses or small networks in organotypic slice cultures is also covered. Many of the experimental setups described can be adapted for other ion channels, cell types, or systems. The manual includes background on the structure, function, and regulation of different voltage- and ligand-gated ion channels. Therefore, it is a useful resource for all cell biologists and neuroscientists seeking to further understand the complex roles of ion channels in normal physiology and disease.
Author: Richard W. Baker
Publisher: John Wiley & Sons
ISBN: 9780470854457
Category : Science
Languages : en
Pages : 556
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Book Description
Table of Contents Preface Acknowledgments for the first edition Acknowledgments for the second edition 1 Overview of Membrane Science and Technology 1 2 Membrane Transport Theory 15 3 Membranes and Modules 89 4 Concentration Polarization 161 5 Reverse Osmosis 191 6 Ultrafiltration 237 7 Microfiltration 275 8 Gas Separation 301 9 Pervaporation 355 10 Ion Exchange Membrane Processes - Electrodialysis 393 11 Carrier Facilitated Transport 425 12 Medical Applications of Membranes 465 13 Other Membrane Processes 491 Appendix 523 Index 535.
Author: Areles Molleman
Publisher: John Wiley & Sons
ISBN: 0470856513
Category : Science
Languages : en
Pages : 186
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Book Description
Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns
Author: Charles G. Cranfield
Publisher: Humana
ISBN: 9781071618424
Category : Science
Languages : en
Pages : 300
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Book Description
This detailed book explores examples of current in vitro and in silico techniques that are at the forefront of lipid membrane research today. Beginning with methods and strategies associated with the creation and use of lipid membrane models in various research settings, the volume continues with electrical impedance spectroscopy strategies and methods to identify how ions and proteins interact with model lipid bilayers, guidance on lipid bilayer in silico molecular dynamics modeling, novel techniques to explore lipid bilayer characteristics using neutron scattering, IR spectroscopy, and atomic force microscopy (AFM), as well as unique fluorescence techniques. Written in the highly successful Methods in Molecular Biology series style, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Membrane Lipids: Methods and Protocols serves as an ideal guide for researchers seeking to further investigate the often complicated world of lipid membrane biophysics.
Author: Rafael Luján
Publisher: Humana
ISBN: 9781493930630
Category : Medical
Languages : en
Pages : 0
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Book Description
Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.
