Handbook of Human Genetic Linkage PDF Download
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Author: Joseph Douglas Terwilliger
Publisher: JHU Press
ISBN: 9780801848032
Category : Medical
Languages : en
Pages : 326
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Book Description
"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- "American Journal of Human Genetics"
Author: Joseph Douglas Terwilliger
Publisher: JHU Press
ISBN: 9780801848032
Category : Medical
Languages : en
Pages : 326
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Book Description
"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- "American Journal of Human Genetics"
Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 9780470997628
Category : Science
Languages : en
Pages : 1616
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Book Description
The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 1119429250
Category : Science
Languages : en
Pages : 1740
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Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Author: Srinivas Aluru
Publisher: CRC Press
ISBN: 1420036270
Category : Computers
Languages : en
Pages : 1108
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Book Description
The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of
Author: Jurg Ott
Publisher: JHU Press
ISBN: 9780801861406
Category : Medical
Languages : en
Pages : 418
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Book Description
Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.
Author: Ben Hui Liu
Publisher: CRC Press
ISBN: 1351414534
Category : Mathematics
Languages : en
Pages : 642
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Book Description
Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.
Author: Pak Sham
Publisher: Wiley
ISBN: 9780470689288
Category : Science
Languages : en
Pages : 0
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Book Description
Rigorous statistical analysis methods for human genetics application Statistics in Human Genetics explores the statistical analysis methods that are critical to good science. Beginning with a brief review of genes, gene structure, variation, and terminology, the book moves into analysis of segregation, genetic linkage, allelic associations, and continuity for a wide range of conditions. From the classic Hardy-Weinberg equation to advanced modeling, algorithms and more, this book provides authoritative guidance toward methods, analysis, and applications for anyone performing quantitative analysis of human genetics.
Author: Guy Bradley-Smith
Publisher: Oxford University Press, USA
ISBN: 0199545367
Category : Medical
Languages : en
Pages : 486
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Book Description
This handbook provides accessible information on specific genetic diseases, and possible genetic components of major diseases, for the primary health care team and junior doctor in training. It assists with why, when, and where to refer patients, and affected families, to get the best advice about genetic disease.
Author: Todd D. Little
Publisher: Oxford University Press
ISBN: 0199934908
Category : Psychology
Languages : en
Pages : 784
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Book Description
Research today demands the application of sophisticated and powerful research tools. Fulfilling this need, The Oxford Handbook of Quantitative Methods is the complete tool box to deliver the most valid and generalizable answers to todays complex research questions. It is a one-stop source for learning and reviewing current best-practices in quantitative methods as practiced in the social, behavioral, and educational sciences. Comprising two volumes, this handbook covers a wealth of topics related to quantitative research methods. It begins with essential philosophical and ethical issues related to science and quantitative research. It then addresses core measurement topics before delving into the design of studies. Principal issues related to modern estimation and mathematical modeling are also detailed. Topics in the handbook then segway into the realm of statistical inference and modeling with chapters dedicated to classical approaches as well as modern latent variable approaches. Numerous chapters associated with longitudinal data and more specialized techniques round out this broad selection of topics. Comprehensive, authoritative, and user-friendly, this two-volume set will be an indispensable resource for serious researchers across the social, behavioral, and educational sciences.
Author: N Manikanda Boopathi
Publisher: Springer Science & Business Media
ISBN: 8132209583
Category : Science
Languages : en
Pages : 304
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Book Description
Genetic mapping and marker assisted selection (MAS) is considered as one of the major tools in genetic improvement of crop plants in this genomics era. This book describes basics in linkage mapping, step-by-step procedure to perform MAS, achievements made so far in different crops, and limitations and prospects of MAS in plant breeding. It summarizes all this in a simple but comprehensive mode using suitable examples so as to explain the concept and its historical developments. To summarize, this book describes technologies for identification of genes of interest through genetic mapping, recaps the major applications of MAS to plant breeding; lists examples in which MAS is being applied to various breeding programs, and emphasizes the various difficulties that limit the application of MAS in plant breeding, providing possible solutions to overcome these difficulties, and finally tries to illustrate the future prospects. This book would be a valuable guide to the under-graduates and post-graduates of agricultural universities and institutes that are interested and/or involved in genetic improvement of crop plants using modern tools. Bibliography listed in this book constitutes two parts: literature cited and further reading. Literature cited contains references cited in the text and further information on the given concept/technique can be obtained from these references. Further reading provides a list of suggested readings for in-depth coverage of the topics.
