Handbook of Chemical Biology of Nucleic Acids PDF Download
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Author: Naoki Sugimoto
Publisher: Springer Nature
ISBN: 9811997764
Category : Science
Languages : en
Pages : 2847
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Book Description
This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.
Author: Naoki Sugimoto
Publisher: Springer Nature
ISBN: 9811997764
Category : Science
Languages : en
Pages : 2847
Get Book Here
Book Description
This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.
Author: Roger L.. Lundblad
Publisher: CRC Press
ISBN: 9780367781132
Category : Biochimie
Languages : en
Pages : 1001
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Book Description
A comprehensive compendium of basic biochemical information, the convenient easy-to-use format of this revised edition includes physical and chemical data on proteins, lipids, vitamins, nucleic acids and carbohydrates. New sections will be added on DNA modification, novel protein analysis methods, lipidomics and chemical biology.
Author:
Publisher: Elsevier
ISBN: 0443217750
Category : Science
Languages : en
Pages : 298
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Book Description
Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Updated release includes the latest information on G4 biology
Author: Victor A. Bloomfield
Publisher: Sterling Publishing Company
ISBN: 9780935702491
Category : Science
Languages : en
Pages : 854
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Book Description
Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.
Author: Aaron M. Leconte
Publisher: American Chemical Society
ISBN: 0841296375
Category : Science
Languages : en
Pages : 168
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Book Description
While the field of directed evolution is vast and varied, it comes from a simple principle: to apply the principles of biological evolution in the laboratory to generate useful molecules. This widely used technique has yielded blockbuster drugs, essential biological tools, and many more useful chemicals. Considering its impact, it’s unsurprising that the 2018 Chemistry Nobel Prize was awarded for the use of directed evolution of proteins. Directed Evolution is an excellent starting point for any scientist interested in directed evolution. This primer aims to provide readers with the foundational knowledge and vocabulary that enables them to tackle the literature and begin designing their projects. Directed evolution, as a field, can be challenging to start in; one of the biggest challenges to starting work in this field is that it requires a different style of thinking than many areas of chemistry. CHAPTER 1 explains this different mentality and then gives an overview of directed evolution: what it is, why it is useful, how evolution is applied in the lab, and how evolution can be applied for human benefit. Given the diversity and quantity of methods and approaches in directed evolution, the remaining chapters focus on helping the readers find the right approach to their specific problem by outlining the basic thought process and classical methods in directed evolution. Specifically, CHAPTER 2 discusses applying directed evolution to nucleic acids. Nucleic acid evolution has several unique features that make it easier to understand conceptually, making it a good starting point for understanding how to think about and leverage evolution. CHAPTERS 3 through 6 cover approaches to evolving proteins. CHAPTER 3 discusses the strengths and weaknesses of different approaches to the diversification of proteins, giving the reader a framework for designing libraries. CHAPTERS 4, 5, and 6 introduce different approaches to sorting by applying selection pressures to find the best variant from a large complex library. Upon completing this primer, the reader will have a theoretical basis to design and execute a directed evolution campaign. They will have the core knowledge to dive into the larger world of directed evolution and begin designing projects that leverage this powerful technique.
Author: Meni Wanunu
Publisher: CRC Press
ISBN: 1439839743
Category : Medical
Languages : en
Pages : 397
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Book Description
Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff
Author: Alessandra Tolomelli
Publisher: Royal Society of Chemistry
ISBN: 1837674558
Category : Science
Languages : en
Pages : 414
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Book Description
Oligopeptides and oligonucleotides, jointly defined as TIDES, have been neglected in the past as potential drugs due to their short half-life and practical difficulties in the manufacturing processes. The consolidation of iterative synthetic techniques, allowing for design of new chemical entities with better pharmaceutical profiles, has led to renewed interest in these compounds. Large scale manufacturing is therefore now required, and it is important that sustainability and green chemistry are considered from the outset. As the two classes display many similarities, advances in sustainable approaches can easily be adapted from one class to the other. This book brings together all of the information on green synthesis of oligopeptides, which is well established, and all of the preliminary data on green oligonucleotides synthesis, creating a resource that will help chemists to bridge the gap between these two areas.
Author: Chandrabhan Verma
Publisher: Elsevier
ISBN: 0323985300
Category : Science
Languages : en
Pages : 670
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Book Description
Handbook of Biomolecules: Fundamentals, Properties and Applications is a comprehensive resource covering new developments in biomolecules and biomaterials and their industrial applications in the fields of bioengineering, biomedical engineering, biotechnology, biochemistry, and their detection methods using biosensors. This book covers the fundamentals of biomolecules, their roll in living organism, structure, sources, important characteristics, and the industrial applications of these biomaterials. Sections explore amino acids, carbohydrates, nucleic acids, proteins, lipids, metabolites and natural products, then go on to discuss purification techniques and detection methods. Applications in biomolecular engineering, biochemistry and biomedical engineering, among others, are discussed before concluding with coverage of biomolecules as anticorrosion materials. - Provides the chronological advancement of biomolecules, their biochemical reaction, and many modern industrial applications in engineering and science - Serves as a valuable source for researchers interested in the fundamentals, basics and modern applications of biomolecules - Covers both synthetic and natural biomolecule synthesis and purification processes and their modern applications - Bridges the gap between the fundamental science of biomolecular chemistry and the relevant technology and industrial applications
Author: Dongyou Liu
Publisher: CRC Press
ISBN: 1420070975
Category : Science
Languages : en
Pages : 572
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Book Description
An Indispensable Roadmap for Nucleic Acid Preparation Although Friedrich Miescher described the first isolation of nucleic acid in 1869, it was not until 1953 that James Watson and Francis Crick successfully deciphered the structural basis of DNA duplex. Needless to say, in the years since, enormous advances have been made in the study of nucleic a
Author: Michael Stumpf
Publisher: John Wiley & Sons
ISBN: 1119952042
Category : Science
Languages : en
Pages : 624
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Book Description
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.
