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Author: Jernej Iskra
Publisher: Springer Science & Business Media
ISBN: 3642251021
Category : Medical
Languages : en
Pages : 326
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Book Description
This book explores topics in Heterocyclic chemistry, including Perfluoroheteroaromatic Chemistry; Monofluorinated Heterocycles; Synthesis of beta-Halofurans; Halogenated Heterocycles as Pharmaceuticals; Green Methods in Halogenation of Heterocycles and more.
Author: Jernej Iskra
Publisher: Springer Science & Business Media
ISBN: 3642251021
Category : Medical
Languages : en
Pages : 326
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Book Description
This book explores topics in Heterocyclic chemistry, including Perfluoroheteroaromatic Chemistry; Monofluorinated Heterocycles; Synthesis of beta-Halofurans; Halogenated Heterocycles as Pharmaceuticals; Green Methods in Halogenation of Heterocycles and more.
Author: Jernej Iskra
Publisher: Springer Science & Business Media
ISBN: 364225103X
Category : Science
Languages : en
Pages : 326
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Book Description
G. Sandford: Perfluoroheteroaromatic Chemistry: Multifunctional Systems from Perfluorinated Heterocycles by Nucleophilic Aromatic Substitution Processes.- A. A. Gakh: Monofluorinated Heterocycles.- R. Dembinski ∙ Y. Li ∙ D. Gundapuneni ∙ A. Decker: Synthesis of beta-Halofurans.- Y. Shermolovich ∙ S. Pazenok: Synthesis of halogenated 5- and 6-membered sulfur- and Sulfur, Nitrogen Containing Heterocycles.- S. Minakata ∙ Y. Takeda ∙ J. Hayakawa: Heterocyclic Reagents Containing Nitrogen-Halogen Bond: Recent Applications.- Michael Schnürch: Recent Progress on the Halogen Dance Reaction on Heterocycles.- T. Kosjek ∙ E. Heath: Halogenated Heterocycles as Pharmaceuticals.- E. Heath ∙ T. Kosjek: Sources, Occurrence and Fate of Halogenated Heterocyclic Pharmaceuticals in the Environment.- J. Iskra: Green Methods in Halogenation of Heterocycles.
Author: Ian Wilson
Publisher:
ISBN:
Category : Heterocyclic compounds
Languages : en
Pages :
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Book Description
Within a number of industries, and particularly within the pharmaceutical industry, there is a desire for reliable, high yielding routes towards large numbers of valuable small molecules that allow a wide range of products to be synthesised. Heterocyclic compounds are particularly sought after as useful compounds, with an estimated 70% of pharmaceutical products being based on heterocyclic structures. A drawback of many traditional routes towards heterocyclic compounds is that the range of substituents that may be placed around the ring is limited. This is especially limiting if ring substituents have to be placed early in a synthesis, reducing the opportunities for elaboration at a late stage. Our approach is to take highly halogenated heterocyclic systems and use them as scaffolds for the synthesis of novel compounds by the sequential replacement of halogen atoms with other functionalities. This approach has led to the generation of a number of novel highly substituted heterocyclic species.
Author: John A. Joule
Publisher: John Wiley & Sons
ISBN: 1405193654
Category : Science
Languages : en
Pages : 719
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Book Description
This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.
Author: H. Suschitzky
Publisher: Elsevier
ISBN: 1483140075
Category : Science
Languages : en
Pages : 350
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Book Description
Progress in Heterocyclic Chemistry, Volume 6, reviews critically the heterocyclic literature essentially published in 1993. The first two chapters are given over to reviews. The first review deals with the subject of the "halogen dance." The second review describes the application of selected "heterocycles as vehicles for synthesis." This type of review dealing mainly with five-membered ring transformations will prove useful to many readers. The remaining chapters describe advances in the heterocyclic field arranged according to ring-size, i.e., three-, four-, five-, six-, seven-, eight-membered rings, and larger rings. Numerous diagrams and a brief index will assist in locating areas of interest.
Author: Alfred Pollak
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Stefan Huber
Publisher: John Wiley & Sons
ISBN: 3527347313
Category : Technology & Engineering
Languages : en
Pages : 418
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Book Description
Long-awaited on the importance of halogen bonding in solution, demonstrating the specific advantages in various fields - from synthesis and catalysis to biochemistry and electrochemistry! Halogen bonding (XB) describes the interaction between an electron donor and the electrophilic region of a halogen atom. Its applicability for molecular recognition processes long remained unappreciated and has mostly been studied in solid state until recently. As most physiological processes and chemical reactions take place in solution, investigations in solutions are of highest relevance for its use in organic synthesis and catalysis, pharmaceutical chemistry and drug design, electrochemistry, as well as material synthesis. Halogen Bonding in Solution gives a concise overview of halogen bond interactions in solution. It discusses the history and electronic origin of halogen bonding and summarizes all relevant examples of its application in organocatalysis. It describes the use of molecular iodine in catalysis and industrial applications, as well as recent developments in anion transport and binding. Hot topic: Halogen bonding is an important interaction between molecules or within a molecule. The field has developed considerably in recent years, with numerous different approaches and applications having been published. Unique: There are several books on halogen bonding in solid state available, but this will be the first one focused on halogen bonding in solution. Multi-disciplinary: Summarizes the history and nature of halogen bonding in solution as well as applications in catalysis, anion recognition, biochemistry, and electrochemistry. Aimed at facilitating exciting future developments in the field, Halogen Bonding in Solution is a valuable source of information for researchers and professionals working in the field of supramolecular chemistry, catalysis, biochemistry, drug design, and electrochemistry.
Author: Angelo Albini
Publisher: Routledge
ISBN: 1351441019
Category : Science
Languages : en
Pages : 369
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Book Description
This book provides a comprehensive presentation of all aspects of heterocyclic N-oxides. Topics discussed include the preparation of these compounds by N-oxidation of heterocycles and simultaneous synthesis of the ring and formation of the N-oxide group; general spectroscopic characteristics and molecular structure; and reactions and recently devel
Author:
Publisher: Academic Press
ISBN: 0080576443
Category : Science
Languages : en
Pages : 423
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Book Description
Advances in Heterocyclic Chemistry
Author: David A. Petrone
Publisher: Springer
ISBN: 3319775073
Category : Science
Languages : en
Pages : 392
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Book Description
This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C‒C) and carbon–halogen (C‒X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
