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Author: David F.V. Lewis
Publisher: Taylor & Francis
ISBN: 1135743282
Category : Science
Languages : en
Pages : 344
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Book Description
Author: David F.V. Lewis
Publisher: Taylor & Francis
ISBN: 1135743282
Category : Science
Languages : en
Pages : 344
Get Book Here
Book Description
Author: David F. V. Lewis
Publisher: CRC Press
ISBN: 1420023047
Category : Medical
Languages : en
Pages : 223
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Book Description
Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Author: David F.V. Lewis
Publisher: CRC Press
ISBN: 0748404430
Category : Science
Languages : en
Pages : 344
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Book Description
This guide to the structure, function and mechanism of the cytochromes P450 focuses on the role of P450s in xenobiotic metabolism and toxicity. Colour illustrations show how modelling of P450s can rationalize their substrate specificity for the metabolism of both endogenous and exogenous chemicals.
Author: David F.V. Lewis
Publisher: CRC Press
ISBN: 1482272776
Category : Science
Languages : en
Pages : 344
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Book Description
This book covers the relevant aspects of cytochromes P450 for understanding their structure, function and mechanisms of action, such as physicochemical characterization methods, redox interactions, evolution and genetics, experimental and theoretical models, induction, inhibition and metabolism.
Author: D. F. V. Lewis
Publisher:
ISBN: 9780367800956
Category : MEDICAL
Languages : en
Pages : 215
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Book Description
Author: David F. V. Lewis
Publisher: CRC Press
ISBN: 9780748408979
Category : Medical
Languages : en
Pages : 252
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Book Description
Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Author: Kelly L. Cozza
Publisher:
ISBN: 9781585620739
Category : Cytochrome P-450
Languages : en
Pages : 262
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Book Description
Topics covered in this volume include: an introduction to the P450 system and basic pharmacology; an introduction to P450 and to this concise guide; basic Pharmacology; metabolic variability - inhibition, induction, and pharmacogenetics; P450 Enzymes; 2D6; 3A4; 1A2; 2C9; 2C19; 2E1; guidelines; how to retrieve and review the literature.
Author: Kelly L. Cozza
Publisher: American Psychiatric Publishing
ISBN:
Category : Medical
Languages : en
Pages : 294
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Book Description
Adverse medication reactions account for up to 7,000 deaths annually in the United States. In today's era of polypharmacy, busy clinicians - especially those who practice in medical/surgical settings - must be able to quickly find and even anticipate psychiatric drug interactions.
Author:
Publisher:
ISBN: 9781071615447
Category : Cytochrome P-450
Languages : en
Pages : 379
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Book Description
Author: Paul R. Ortiz de Montellano
Publisher: Springer Science & Business Media
ISBN: 1475723911
Category : Medical
Languages : en
Pages : 655
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Book Description
In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem structural techniques. Only a few P450 primary sequences were available in 1985, whereas hundreds of P450 sequences are now available. Site-specific mutagenesis was then mostly a proverbial gleam in the eye of the P450 community, but it is now a standard technique in the research repertoire. The first crystal structure of a cytochrome P450 enzyme had just been solved in 1985 and appeared on the cover of the first edition. Today, the high-reso lution crystal structures of four soluble bacterial P450 enzymes are available and the race is on to develop approaches that will permit us to determine the structures of the membrane-bound forms of the enzyme. The past ten years has seen phenomenal progress let us hope that the next ten will prove equally exciting. The book is informally divided into four sections. In order to hold the book close to the advancing front of research, some of the chapter topics from the first edition have been dropped to make room for new or expanded topics.
