Glycosphingolipids in the Central Nervous System PDF Download
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Author: Zhongwu Guo
Publisher: Elsevier
ISBN: 0443161577
Category : Science
Languages : en
Pages : 455
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Book Description
Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity. - Presents a systematic review of literature and potential future developments in Glycosphingolipid research - Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties - Provides an overview, general trends, cases studies, summaries and future implications
Author: Zhongwu Guo
Publisher: Elsevier
ISBN: 0443161577
Category : Science
Languages : en
Pages : 455
Get Book Here
Book Description
Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity. - Presents a systematic review of literature and potential future developments in Glycosphingolipid research - Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties - Provides an overview, general trends, cases studies, summaries and future implications
Author: Robert K. Yu
Publisher: Springer
ISBN: 1493911546
Category : Medical
Languages : en
Pages : 590
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Book Description
A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.
Author: Minoru Fukuda
Publisher: Oxford University Press, USA
ISBN: 9780198525387
Category : Language Arts & Disciplines
Languages : en
Pages : 272
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Book Description
Carbohydrates play a major role in brain function. In the past decade, tremendous progress has been made in understanding their structure and function within the nervous system. This book presents a state of the art account of this rapidly expanding field.
Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category : Medical
Languages : en
Pages : 694
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Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Hinrich Rahmann
Publisher: Springer Science & Business Media
ISBN: 3642719325
Category : Science
Languages : en
Pages : 632
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Book Description
The NATO Advanced Research Workshop on "Gangliosides and Modu lation of Neuronal Functions" was held at the University of Stutt gart-Hohenheim, Federal Republic of Germany, on October 20 - 24, 1986. About 70 participants from 10 countries presented papers on a wide range of topics all concerning the ganglioside theme. The content of the workshop consisted of the following chap ters: (1) Fundamentals for research on function of gangliosides; (2) Brain ganglioside metabolism; (3) Cell specific distribution and differentiation-related ex pression of brain gangliosides; (4) Gangliosides and neuronal plasticity; (5) Bio-medical potential of exogenous ganglioside application on neuronal function; and (6) Critical assessments on aspects of ganglioside therapy. The aim of the workshop was to sum up and discuss the present knowledge in the respective fields. Despite intensive research on gangliosides ever since Ernst Klenk discovered them in 1936, the biological function of. these amphiphilic, "sphinx-like" glycosphingo lipids remains elusive. Over the past few years, several thousands of articles on gangliosides have been published demonstrating very special properties of these glycolipids and their possible in volvement in diverse biological phenomena. As far as we know up to the present time, these properties may be due to particular physico-chemical attributes of these compounds, especially in com bination with calcium. The results obtained so far have shed light not only on pos sible functional roles of gangliosides with regard to cellular induction and organization, but have also unexpectedly opened up VI a whole new field of therapeutic applications for these compounds.
Author: Matthew Warren Spence
Publisher:
ISBN:
Category :
Languages : en
Pages : 314
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Book Description
Author: Abel Lajtha
Publisher: Springer Science & Business Media
ISBN: 0387326707
Category : Medical
Languages : en
Pages : 332
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Book Description
The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.
Author: Charles Chalfant
Publisher: Springer Science & Business Media
ISBN: 1441967419
Category : Science
Languages : en
Pages : 311
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Book Description
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Author: Robert W. Ledeen
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 454
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Book Description
This is the proceedings of the Satellite Symposium to the Combined Meeting of the International and American Societies for Neurochemistry, July 13-16, 1997. It covers sphingosine and its derivatives, sphingoids as receptor and enzyme modulators, sphingolipid metabolism and neuronal differentiation, gangliosides as neuroprotective modulators, sphingolipids in neuropathology, and gangliosides as potential therapeutic agents for neurological disorders.
Author: Hans-Joachim Gabius
Publisher: John Wiley & Sons
ISBN: 3527644946
Category : Science
Languages : en
Pages : 560
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Book Description
A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
