Author: Naoyuki Taniguchi
Publisher: Elsevier
ISBN: 0323149626
Category : Science
Languages : en
Pages : 458
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Book Description
Glutathione Centennial: Molecular Perspectives and Clinical Implications is a collection of papers presented at the international symposium by the same titles, held in Osaka, Japan on December 1-4, 1988. This symposium concentrates on the developments is glutathione field, especially those related to molecular and clinical problems. This book is organized into five parts encompassing 30 chapters. Part I deals with the metabolic regulation, thermodynamic and kinetic properties, and enzyme regulation of glutathione. Part II examines the gene expression and molecular mechanism of glutathione-related enzymes, while Part III explores the association between carcinogenesis, xenobiotic compounds, and glutathione. Part IV highlights the clinical implications of glutathione, particularly its effect on vasospasm in subarachnoid hemorrhage and experimental hepatitis. Part V discusses the mechanism and regulation of biological transport of glutathione. This book will be of great value to glutathione enthusiasts and to many scientists in the brad fields of biology and medicine, and to their students.
Author: Leopold Flohe
Publisher: CRC Press
ISBN: 1351261746
Category : Medical
Languages : en
Pages : 642
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Book Description
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1174
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Christopher Ari Shaw
Publisher: Routledge
ISBN: 1351444611
Category : Medical
Languages : en
Pages : 410
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Book Description
The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.
Author: Henrik Friis
Publisher: CRC Press
ISBN: 1420042351
Category : Medical
Languages : en
Pages : 273
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Book Description
Exploring the role of micronutrients in HIV, this book provides a comprehensive a review of recently published human studies and intervention trials and other important epidemiology based literature. It covers the history, biochemistry, biological functions, and food sources of individual micronutrients and reviews their roles in host defense and resistance to infections in general, and HIV in particular. The editorial panel presents a critical analysis of how existing micronutrient interventions can be promoted, expanded, and modified to reduce the impact of the HIV pandemic. They discuss how this information can be applied in countries where HIV is widespread and treatment unavailable.
Author:
Publisher: Academic Press
ISBN: 0080530168
Category : Science
Languages : en
Pages : 333
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Book Description
This informative publication brings together knowledge of various aspects of cellular regulation. Current Topics in Cellular Regulation reviews the progress being made in those specialized areas of study that have undergone substantial development. It also publishes provocative new theories and concepts and serves as a forum for the discussion of general principles. Researchers in cellular regulation as well as biochemists, molecular and cell biologists, microbiologists, and biophysicists will find Current Topics in Cellular Regulation a useful source of up-to-date information. - Regulation of Iron Metabolism in Eukaryotes - Regulation of Fas-Mediated Apoptosis - Aging and Regulation of Apoptosis - Regulation of Bacterial Responses of Oxidaditive Stress - Regulation of NF-(B and Disease Control - Mechanism and Regulation of Bone Resorption - Gene Regulation by Reactive Oxygen Species - Structure, Mechanism, and Specificity of Protein-Tyrosine Phosphatases
Author: Daniel L. Purich
Publisher: John Wiley & Sons
ISBN: 9780471246442
Category : Science
Languages : en
Pages : 304
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Book Description
Biological catalysis plays a dominant role both in fermentation and industrial process chemistry. This collection of chapters, written by a well-known biochemist and enzymologist, should serve as an invaluable reference to those investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 1090
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Book Description
Author: T. Andus
Publisher: Springer Science & Business Media
ISBN: 9780792387589
Category : Medical
Languages : en
Pages : 438
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Book Description
The gastrointestinal tract has a number of unique features. Its extensive surface is formed by a single layer of rapidly renewing cells, the intestinal epithelial cells. These cells are in contact with a number of other cell populations, including the largest part of the immune system, and with an excessive luminal antigen load, including vast numbers of bacteria. Furthermore two more organs, namely liver and pancreas, are part of the system. The rapid renewal of the epithelial layer, the interactions of different cell types, and the balance between cell proliferation and death, have been fascinating subjects of studies in recent years. Much has been learned, and cytokines have emerged as important mediators for all these interactions and homeostatic systems. This book, the proceedings of the Falk Symposium 113 on `Cytokines and Cell Homeostasis in the Gastrointestinal Tract', held in Regensburg, Germany, 16-18 September 1999, provides a forum for basic scientists and interested clinicians to exchange ideas, to discuss concepts and to plan further studies.
Author:
Publisher: Elsevier
ISBN: 0080468845
Category : Medical
Languages : en
Pages : 6448
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Book Description
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
