Genetics of Melanoma PDF Download
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Author: Carlos A. Torres-Cabala
Publisher: Springer
ISBN: 1493935542
Category : Medical
Languages : en
Pages : 291
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Book Description
This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.
Author: Carlos A. Torres-Cabala
Publisher: Springer
ISBN: 1493935542
Category : Medical
Languages : en
Pages : 291
Get Book Here
Book Description
This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.
Author: Anja K. Bosserhoff
Publisher: Springer
ISBN: 9783319823225
Category : Medical
Languages : en
Pages : 0
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Book Description
This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.
Author: Lester Davids
Publisher: BoD – Books on Demand
ISBN: 9535109766
Category : Medical
Languages : en
Pages : 388
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Book Description
The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.
Author: Miroslav Blumenberg
Publisher: BoD – Books on Demand
ISBN: 1789230942
Category : Medical
Languages : en
Pages : 214
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Book Description
Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
Author: Parvin Mehdipour
Publisher: Springer
ISBN: 3319645501
Category : Medical
Languages : en
Pages : 1189
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Book Description
The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.
Author: Anja K. Bosserhoff
Publisher: Springer
ISBN: 3319413198
Category : Medical
Languages : en
Pages : 443
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Book Description
This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.
Author: Garden Grove Garden Grove Press
Publisher:
ISBN: 9781545053478
Category :
Languages : en
Pages : 250
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Book Description
This article collection reviews the medical genetics of melanoma and includes 25 papers by various authors. Topics include: Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma; The stable traits of melanoma genetics: an alternate approach to target discovery; Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma; Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naive patient melanomas; Discrepant alterations in main candidate genes among multiple primary melanomas; MiR-21: an environmental driver of malignant melanoma?; Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts; Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona; A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib; Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies; Melanoma genome evolution across species; Clinical application of genetic testing for posterior uveal melanoma; AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment; Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study; Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"; The association between Parkinson's disease and melanoma: a systematic review and meta-analysis; Gene expression profiling of melanoma cells - searching the haystack; The immune-related role of BRAF in melanoma; Vemurafenib resistance reprograms melanoma cells towards glutamine dependence; Melanoma cells influence the differentiation pattern of human epidermal keratinocytes; Exome sequencing in primary melanoma identifies novel drivers of melanoma progression; Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face; Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy; Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study; Melanoma risk loci as determinants of melanoma recurrence and survival. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author: Sverre Heim
Publisher: John Wiley & Sons
ISBN: 1118795512
Category : Medical
Languages : en
Pages : 645
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Book Description
The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
Author: Charles M. Balch
Publisher: Springer
ISBN: 9783030050689
Category : Medical
Languages : en
Pages : 0
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Book Description
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
Author: Antonio Russo
Publisher: Springer Nature
ISBN: 3030560511
Category : Medical
Languages : en
Pages : 1104
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Book Description
This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.
