Genetics of Antibiotic-producing Microorganisms PDF Download
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Author: Giuseppe Sermonti
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 408
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Book Description
Author: Giuseppe Sermonti
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 408
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Book Description
Author: Satoshi Omura
Publisher: Springer Science & Business Media
ISBN: 1461244129
Category : Science
Languages : en
Pages : 373
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Book Description
Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Author: Colin Stuttard
Publisher: Butterworth-Heinemann
ISBN: 1483295079
Category : Medical
Languages : en
Pages : 704
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Book Description
* Emphasizes the molecular genetics of antibiotic production * Provides the latest information on the organization of genes encoding the biosynthetic pathway * Explores the mechanisms governing their expression and regulation * Examines the role of resistance genes in protecting organisms from their own lethal products Genetics and Biochemistry of Antibiotic Production brings together the most up-to-date information on the genetic and biochemical mechanisms involved in antibiotic production. A collection of internationally recognized authors provide the latest information on the organization, function and regulation of genes responsible for antibiotic synthesis in a range of bacteria. This unique book groups antibiotics according to their biosynthetic affiliation, providing a background into evolutionary relationships while raising intriguing questions about the raison d'etre of antibiotics in nature.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309030447
Category : Medical
Languages : en
Pages : 393
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Book Description
Author: Waclaw Szybalski
Publisher:
ISBN:
Category : Genetics
Languages : en
Pages : 236
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Book Description
Author:
Publisher:
ISBN:
Category : Streptomyces
Languages : en
Pages : 210
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Book Description
Author: D. A. Hopwood
Publisher: Oxford University Press
ISBN: 019515066X
Category : Medical
Languages : en
Pages : 261
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Book Description
This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Author: New York Academy of Sciences
Publisher:
ISBN:
Category : Enzymes
Languages : en
Pages : 1040
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Book Description
Author:
Publisher:
ISBN:
Category : Genetics
Languages : en
Pages : 210
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Book Description
Author: Silvia Buroni
Publisher: Frontiers Media SA
ISBN: 2889632229
Category :
Languages : en
Pages : 171
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Book Description
Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better understanding of the dynamics that lead to the evolution of antibiotic resistance remains essential for the development of more efficient strategies to combat this phenomenon. The recent developments in genomics have greatly contributed to expand our knowledge on the mechanisms of microbial resistance, and of the processes by which they emerge, develop and spread. Different approaches and expertise can be used to accelerate advances in this area, ranging from clinical studies on the evolution of resistance in vivo, to theoretical modeling and the study of evolution in the laboratory.
