Function of the Stroma-Derived Metalloproteinase, Stromelysin-3, in Invasive Breast Carcinomas PDF Download
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Category :
Languages : en
Pages : 0
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Book Description
Stromelysin-3 (ST-3), a member of the matrix metalloproteinase (MMP) family, is expressed in stromal cells surrounding invasive breast carcinoma cells. where it undergoes processing to its active form by an intracellular, proprotein convertase-dependent pathway. While strong correlations between disease progression and ST-3 expression suggest that the proteinase plays a critical role in breast cancer, human ST-3 is the only matrix metalloproteinase that does not express a marked ability to degrade components of the extracellular matrix (ECM). To further characterize the role of ST-3 in vivo, our attention focused on the analysis of lines of transgenic mice wherein the whey acidic protein (WAP) gene was used to direct human ST-3 expression to mammary tissue during late pregnancy through lactation. In these studies, high levels of the ST-3 transgene were generated in vivo which unexpectedly triggered a massive involution program. Surprisingly, ST-3 not only induced an apoptotic program, but also initiated changes in the underlying basement membrane in vivo. In addition, ST-3 expression also appeared to induce an exaggerated angiogenic response in involuting tissues. These data provide the first evidence that ST-3 can regulate mammary epithelial- ECM interactions and angiogenesis in vivo.
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Languages : en
Pages : 0
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Book Description
Stromelysin-3 (ST-3), a member of the matrix metalloproteinase (MMP) family, is expressed in stromal cells surrounding invasive breast carcinoma cells. where it undergoes processing to its active form by an intracellular, proprotein convertase-dependent pathway. While strong correlations between disease progression and ST-3 expression suggest that the proteinase plays a critical role in breast cancer, human ST-3 is the only matrix metalloproteinase that does not express a marked ability to degrade components of the extracellular matrix (ECM). To further characterize the role of ST-3 in vivo, our attention focused on the analysis of lines of transgenic mice wherein the whey acidic protein (WAP) gene was used to direct human ST-3 expression to mammary tissue during late pregnancy through lactation. In these studies, high levels of the ST-3 transgene were generated in vivo which unexpectedly triggered a massive involution program. Surprisingly, ST-3 not only induced an apoptotic program, but also initiated changes in the underlying basement membrane in vivo. In addition, ST-3 expression also appeared to induce an exaggerated angiogenic response in involuting tissues. These data provide the first evidence that ST-3 can regulate mammary epithelial- ECM interactions and angiogenesis in vivo.
Author: Neil J. Clendeninn
Publisher: Springer Science & Business Media
ISBN: 159259011X
Category : Medical
Languages : en
Pages : 371
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Book Description
Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.
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Publisher: Elsevier Health Sciences
ISBN: 0702069280
Category : Medical
Languages : en
Pages : 800
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Book Description
Comprehensive and easy to read, Weedon’s Skin Pathology Essentials, 2nd Edition, by Ronald B. Johnston, MD, provides a superb overview of key diagnoses in dermatopathology and is ideal for quickly looking up practical problems in the recognition and diagnosis of skin lesions both clinically and histologically. Thousands of illustrations, an accessible format, and cross references to the encyclopedic and authoritative Weedon’s Skin Pathology, 4th Edition, make this a must-have reference for pathologists and dermatologists in practice and in training. More than 3,300 color histopathologic and clinical images provide complete visual coverage of key diagnostic points for dermatological entities Numerous summary tables and diagnostic algorithms guide you to the most likely diagnosis and set of differential diagnoses for numerous inflammatory and neoplastic skin conditions. Outline format and bullet point style make essential information for any given lesion easy to find and review. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. More illustrations of rare conditions and unusual manifestations, and additional entries in the Tumors, Infections, and Infestations sections.
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811061416
Category : Medical
Languages : en
Pages : 668
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Book Description
This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author: Matthew R. Lindberg, MD
Publisher: Elsevier Health Sciences
ISBN: 0323376754
Category : Medical
Languages : en
Pages : 882
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Book Description
Part of the highly regarded Diagnostic Pathology series, this updated volume by Matthew Lindberg, MD, is a visually stunning, easy-to-use reference covering all aspects of soft tissue pathology. Outstanding images – including gross pathology, a wide range of stains, and detailed medical illustrations – make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Packed with even more high-resolution images than the previous edition – more than 2,000 images in all – it clearly depicts not only the key features of each tumor, but also the wide array of histologic variants. "I'd strongly recommend this book to both pathology residents and seasoned diagnostic pathologists alike." Reviewed by Todd Stevens, Oct 2015 Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Thoroughly updated content throughout with a particular emphasis on the practical information that directly assists in making and supporting a diagnosis. High-quality, carefully annotated histologic images depicting unique features provide extensive photodocumentation of the diverse spectrum of mesenchymal tumors and their morphologic variants. Up-to-date coverage of the most recent WHO soft tissue tumor classification scheme, the wealth of new data in the field, and the newest and most diagnostically useful antibody and molecular tests. Introductory sections include new "Approach to Diagnosis" chapters that help you successfully diagnose challenging soft tissue tumors through the recognition of distinct architectural growth pattern and histologic features. More differential tables help you decide which stains to order and when, and new algorithmic guides assist with work-up and diagnosis of soft tissue tumors.
Author: William C. Parks
Publisher: Springer Science & Business Media
ISBN: 3642168612
Category : Science
Languages : en
Pages : 262
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Book Description
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Author: Shamim I. Ahmad
Publisher: Springer
ISBN: 3319560174
Category : Medical
Languages : en
Pages : 367
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Book Description
This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter. The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted. The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes. The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields. It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light.
Author: Cheng Dong
Publisher: Springer
ISBN: 3319952943
Category : Medical
Languages : en
Pages : 378
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Book Description
This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
Author: Jai Prakash
Publisher: CRC Press
ISBN: 1000470709
Category : Medical
Languages : en
Pages : 392
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Book Description
The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
Author:
Publisher: UM Libraries
ISBN:
Category : Research
Languages : en
Pages : 422
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Book Description
