Author: M. Frederick Hawthorne
Publisher: Springer
ISBN: 1461512859
Category : Medical
Languages : en
Pages : 1389
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Book Description
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Author: Wolfgang A.G. Sauerwein
Publisher: Springer Science & Business Media
ISBN: 3642313345
Category : Medical
Languages : en
Pages : 545
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Book Description
Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Author: Harald Paganetti
Publisher: CRC Press
ISBN: 1439836450
Category : Medical
Languages : en
Pages : 691
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Book Description
Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Author: A.H. Soloway
Publisher: Springer Science & Business Media
ISBN: 9780306445675
Category : Gardening
Languages : en
Pages : 872
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Book Description
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Author: National Research Council
Publisher: National Academies Press
ISBN: 030908637X
Category : Science
Languages : en
Pages : 177
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Book Description
Recent scientific and technical advances have made it possible to create matter in the laboratory under conditions relevant to astrophysical systems such as supernovae and black holes. These advances will also benefit inertial confinement fusion research and the nation's nuclear weapon's program. The report describes the major research facilities on which such high energy density conditions can be achieved and lists a number of key scientific questions about high energy density physics that can be addressed by this research. Several recommendations are presented that would facilitate the development of a comprehensive strategy for realizing these research opportunities.
Author: Yinghuai Zhu
Publisher: World Scientific
ISBN: 9811268045
Category : Science
Languages : en
Pages : 233
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Book Description
Boron has long occupied a privileged role in chemistry (as a catalyst component) and human health (as a micronutrient). In 1951, boron science took a momentous leap forward with its application in clinical cancer research. The seventy or so years since have witnessed exciting developments in the technology now known as Boron Nuclear Capture Therapy (BNCT), a binary form of radiotherapy that lethally combines two separately non-lethal constituents: a boron-based radiosensitizer and non-ionizing neutron radiation. Frontiers in Boron-based Medicinal Chemistry is a one-stop resource on the current state of BNCT and promising works in the pipeline. It begins with an introduction to general boron chemistry, with extensive discussion on important boron compounds including boranes, boronic acids, carboranes, and FDA-approved boron drugs. Chapter 2 looks at BNCT in clinical trials, while Chapter 3 describes emerging next-generation agents such as boron-based nanoparticles and dendrimers. The penultimate chapter summarizes the currently used and emerging imaging techniques in BNCT, namely, PET, CT, MRI and fluorescence microscopy. The book concludes with a technically heavy chapter on neutron sources and dosimetry. The cutting-edge information contained in this authoritative volume will be a valuable resource for all those involved in mankind's endless struggle against cancer.
Author: Michael J. Welch
Publisher: John Wiley & Sons
ISBN: 9780471495604
Category : Medical
Languages : en
Pages : 872
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Book Description
A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States
Author: Tadaaki Kirita
Publisher: Springer
ISBN: 4431549382
Category : Medical
Languages : en
Pages : 427
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Book Description
Oral cancer is frequently diagnosed late, when the disease has advanced with lesions that are large and deeply invasive and with metastasis to regional lymph nodes, leading to increased mortality. Moreover, late diagnosis and treatment often result in considerable morbidity of oral and maxillofacial structures and poor appearance and function following therapy. This book provides head and neck oncologists, oral oncologists, oral and maxillofacial surgeons, medical oncologists, dentists and other members of dental teams furnishing supportive care with a systematic review of recent diagnostic and therapeutic advances in oral cancer. The various authoritative chapters are prepared by specialists who are active leaders in each basic and clinical field. All chapters address individual and collective issues that arise in managing oral cancer patients with difficult treatment problems and provide insight into the multiple valid management approaches available. The authors offer an extensive source of information about oral cancers and encourage the clinician to be flexible and innovative, giving physicians and medical personnel the background information to make the best, educated, responsible decisions for individual patients.
Author: U.S. Atomic Energy Commission
Publisher:
ISBN:
Category : Neutron sources
Languages : en
Pages : 856
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309173663
Category : Science
Languages : en
Pages : 222
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Book Description
Dramatic progress has been made in all branches of physics since the National Research Council's 1986 decadal survey of the field. The Physics in a New Era series explores these advances and looks ahead to future goals. The series includes assessments of the major subfields and reports on several smaller subfields, and preparation has begun on an overview volume on the unity of physics, its relationships to other fields, and its contributions to national needs. Nuclear Physics is the latest volume of the series. The book describes current activity in understanding nuclear structure and symmetries, the behavior of matter at extreme densities, the role of nuclear physics in astrophysics and cosmology, and the instrumentation and facilities used by the field. It makes recommendations on the resources needed for experimental and theoretical advances in the coming decade.
