From Ecology to Cancer Biology and Back Again PDF Download
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Author: Frederick R. Adler
Publisher: Frontiers Media SA
ISBN: 2889746151
Category : Science
Languages : en
Pages : 259
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Author: Frederick R. Adler
Publisher: Frontiers Media SA
ISBN: 2889746151
Category : Science
Languages : en
Pages : 259
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Book Description
Author: Athena Aktipis
Publisher: Princeton University Press
ISBN: 0691163847
Category : Medical
Languages : en
Pages : 256
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Book Description
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1439170916
Category : Health & Fitness
Languages : en
Pages : 624
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Book Description
Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is a magnificent, profoundly humane "biography" of cancer--from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive--and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Author: Beata Ujvari
Publisher: Academic Press
ISBN: 0128043806
Category : Medical
Languages : en
Pages : 292
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Book Description
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. - Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine - Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors - Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems - Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
Author: Anya Plutynski
Publisher: Oxford University Press
ISBN: 0199967466
Category : Science
Languages : en
Pages : 281
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Book Description
In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.
Author: Çagan H. Sekercioglu
Publisher: University of Chicago Press
ISBN: 022638277X
Category : Science
Languages : en
Pages : 398
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Book Description
For over one hundred years, ornithologists and amateur birders have jointly campaigned for the conservation of bird species, documenting not only birds’ beauty and extraordinary diversity, but also their importance to ecosystems worldwide. But while these avian enthusiasts have noted that birds eat fruit, carrion, and pests; spread seed and fertilizer; and pollinate plants, among other services, they have rarely asked what birds are worth in economic terms. In Why Birds Matter, an international collection of ornithologists, botanists, ecologists, conservation biologists, and environmental economists seeks to quantify avian ecosystem services—the myriad benefits that birds provide to humans. The first book to approach ecosystem services from an ornithological perspective, Why Birds Matter asks what economic value we can ascribe to those services, if any, and how this value should inform conservation. Chapters explore the role of birds in such important ecological dynamics as scavenging, nutrient cycling, food chains, and plant-animal interactions—all seen through the lens of human well-being—to show that quantifying avian ecosystem services is crucial when formulating contemporary conservation strategies. Both elucidating challenges and providing examples of specific ecosystem valuations and guidance for calculation, the contributors propose that in order to advance avian conservation, we need to appeal not only to hearts and minds, but also to wallets.
Author: Paul Schmid-Hempel
Publisher: Oxford University Press
ISBN: 0192568159
Category : Medical
Languages : en
Pages : 572
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Book Description
Parasites and infectious diseases are everywhere and represent some of the most potent forces shaping the natural world. They affect almost every aspect imaginable in the life of their hosts, even as far as the structure of entire ecosystems. Hosts, in turn, have evolved complex defences, with immune systems being among the most sophisticated processes known in nature. In response, parasites have again found ways to manipulate and exploit their hosts. Ever since life began, hosts and parasites have taken part in this relentless co-evolutionary struggle with far-reaching consequences for us all. Today, concepts borrowed from evolution, ecology, parasitology, and immunology have formed a new synthesis for the study of host-parasite interactions. Evolutionary parasitology builds on these established fields of scientific enquiry but also includes some of the most successful inter-disciplinary areas of modern biology such as evolutionary epidemiology and ecological immunology. The first edition of this innovative text quickly became the standard reference text for this new discipline. Since then, the field has progressed rapidly and an update is now required. This new edition has been thoroughly revised to provide a state-of-the-art overview, from the molecular bases to adaptive strategies and their ecological and evolutionary consequences. It includes completely new material on topics such as microbiota, evolutionary genomics, phylodynamics, within-host evolution, epidemiology, disease spaces, and emergent diseases. Evolutionary Parasitology is suitable for advanced undergraduates, graduate level students, and interdisciplinary researchers from a variety of fields including immunology, genetics, sexual selection, population ecology, behavioural ecology, epidemiology, and evolutionary biology. Those studying and working in adjacent fields such as conservation biology, virology, medicine, and public health will also find it an invaluable resource for connecting to the bases of their science.
Author: Yang Kuang
Publisher: CRC Press
ISBN: 1584889918
Category : Mathematics
Languages : en
Pages : 469
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Book Description
Introduction to Mathematical Oncology presents biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of the models. They also develop new mathematical tools and look to future improvements on dynamical models. After introducing the general theory of medicine and exploring how mathematics can be essential in its understanding, the text describes well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. It continues the topic of avascular tumor growth in the context of partial differential equation models by incorporating the spatial structure and physiological structure, such as cell size. The book then focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. It also examines more mechanistically formulated models, including cell quota-based population growth models, with applications to real tumors and validation using clinical data. The remainder of the text presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts. Extensively classroom-tested in undergraduate and graduate courses, this self-contained book allows instructors to emphasize specific topics relevant to clinical cancer biology and treatment. It can be used in a variety of ways, including a single-semester undergraduate course, a more ambitious graduate course, or a full-year sequence on mathematical oncology.
Author: Charles J. Krebs
Publisher: Indo American Books
ISBN: 9788189617431
Category : Science
Languages : en
Pages : 210
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Book Description
Ecology Is A Fascinating Subject. This Is A Book To Introduce You To It And The Problems Ecologists Try To Analyze. Above All It Is An Attempt To Present The Subject In A Direct, Simple Form Without Including The Detail That Is Necessary In A More Conventional Textbook And Without Burdening The Subject With Abstruse Definitions Or Voluminous Statistics. So Do Not View This Book As A Text But As Supplemental Reading Designed For An Introductory Biology Course Or For A First Course In Ecology.
Author: Jeffrey Jerome Cohen
Publisher: U of Minnesota Press
ISBN: 1452955751
Category : Philosophy
Languages : en
Pages : 435
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Book Description
The words most commonly associated with the environmental movement—save, recycle, reuse, protect, regulate, restore—describe what we can do to help the environment, but few suggest how we might transform ourselves to better navigate the sudden turns of the late Anthropocene. Which words can help us to veer conceptually along with drastic environmental flux? Jeffrey Jerome Cohen and Lowell Duckert asked thirty brilliant thinkers to each propose one verb that stresses the forceful potential of inquiry, weather, biomes, apprehensions, and desires to swerve and sheer. Each term is accompanied by a concise essay contextualizing its meaning in times of resource depletion, environmental degradation, and global climate change. Some verbs are closely tied to natural processes: compost, saturate, seep, rain, shade, sediment, vegetate, environ. Many are vaguely unsettling: drown, unmoor, obsolesce, power down, haunt. Others are enigmatic or counterintuitive: curl, globalize, commodify, ape, whirl. And while several verbs pertain to human affect and action—love, represent, behold, wait, try, attune, play, remember, decorate, tend, hope—a primary goal of Veer Ecology is to decenter the human. Indeed, each of the essays speaks to a heightened sense of possibility, awakening our imaginations and inviting us to think the world anew from radically different perspectives. A groundbreaking guide for the twenty-first century, Veer Ecology foregrounds the risks and potentialities of living on—and with—an alarmingly dynamic planet. Contributors: Stacy Alaimo, U of Texas at Arlington; Joseph Campana, Rice U; Holly Dugan, George Washington U; Lara Farina, West Virginia U; Cheryll Glotfelty, U of Nevada, Reno; Anne F. Harris, DePauw U; Tim Ingold, U of Aberdeen; Serenella Iovino, U of Turin; Stephanie LeMenager, U of Oregon; Scott Maisano, U of Massachusetts, Boston; Tobias Menely, U of California, Davis; Steve Mentz, St. John’s U; J. Allan Mitchell, U of Victoria; Timothy Morton, Rice U; Vin Nardizzi, U of British Columbia; Laura Ogden, Dartmouth College; Serpil Opperman, Hacettepe U, Ankara; Daniel C. Remein, U of Massachusetts, Boston; Margaret Ronda, U of California, Davis; Nicholas Royle, U of Sussex; Catriona Sandilands, York U; Christopher Schaberg, Loyola U; Rebecca R. Scott, U of Missouri; Theresa Shewry, U of California, Santa Barbara; Mick Smith, Queen’s U; Jesse Oak Taylor, U of Washington; Brian Thill, Golden West College; Coll Thrush, U of British Columbia, Vancouver; Cord J. Whitaker, Wellesley College; Julian Yates, U of Delaware.
