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Author: Robert J. Sawyer
Publisher: Macmillan
ISBN: 9780765313164
Category : Fiction
Languages : en
Pages : 354
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Book Description
A scientist in Berkeley, California discovers that a series of murders is the work of an insurance company. After collecting information on the genes of policy holders, the company analyzed them to see which ones were a bad risk and proceeded to kill them. By the author of The Terminal Experiment.
Author: Robert J. Sawyer
Publisher: Macmillan
ISBN: 9780765313164
Category : Fiction
Languages : en
Pages : 354
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Book Description
A scientist in Berkeley, California discovers that a series of murders is the work of an insurance company. After collecting information on the genes of policy holders, the company analyzed them to see which ones were a bad risk and proceeded to kill them. By the author of The Terminal Experiment.
Author: John F. Atkins
Publisher: Springer Science & Business Media
ISBN: 0387893822
Category : Science
Languages : en
Pages : 473
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Book Description
The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.
Author: J. Larry Jameson
Publisher: Elsevier Health Sciences
ISBN: 032332195X
Category : Medical
Languages : en
Pages : 3707
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Book Description
Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Now in full color, with special design treatment for at-a-glance pediatric content, helping to distinguish the pediatric content. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
Author: Cornelius Wilhelmus Radboud Jozef Cremers
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805574495
Category : Medical
Languages : en
Pages : 263
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Book Description
A decade of innovative findings in the research of molecular biology of hearing and deafness is reflected in this volume. The genetic causes for many types of syndromic and non-syndromic deafness are identified and genotypic-phenotypic relationships are explored. Although the type and degree of deafness caused by mutations in different genes significantly overlap, relatively unique age-related audiometric profiles are also emerging. For example, the audioprofile of DFNA1 and DFNA6-14 is a low-frequency sensorineural hearing loss; with DFNA8-14 it is a mid-frequency sensorineural hearing loss, and with DFNA2, DFNA5 and DFNA20-26 it is a high-frequency progressive hearing loss. Recognizing such audioprofiles can facilitate well-guided decision-making in clinical practice and can direct genetic testing for deafness. With an accurate genetic diagnosis, prognostic information can be provided to patients and their families. In the future, gene-specific habilitation options may also become available. To keep up to date with new clinical standards of diagnosing genetic hearing impairment, this book is indispensable reading to otorhinolaryngologists and audiologists.
Author:
Publisher: Academic Press
ISBN: 0080578365
Category : Medical
Languages : en
Pages : 403
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Book Description
This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation.Key Features* Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family* Explores immunodeficiencies, including:* Immunoglobulin deficiencies and B cells development* Glycosyl Phosphatidylinositol (GPI)-anchor and Paroxysmal Nocturnal Hemoglobinuria (PNH)* Investigates the links molecular pathology established between deficiencies in GPI-anchor synthesis and PNH* Includes the use of Multiple Antigen Peptides (MAPs) to induce protective immune response* Offers a timely update on Eosinophils' role in disease* Covers histology of Germinal center reaction of a spleen twelve days after primary immunization* Includes new research on cytotoxic T-lymphocytes* Presents the multiple roles of Nitric oxide (NO) in the inflammatory response
Author: Karl Kadish
Publisher: Elsevier
ISBN: 0123932246
Category : Science
Languages : en
Pages : 388
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Book Description
The Porphyrin Handbook, Volume 14: Medical Aspects of Porphyrins provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into 12 chapters, this volume begins with an overview of the underlying diagnostic features, mechanisms, and available treatments of erythropoietic disorders due to defective heme biosynthesis. This text then examines the physiopathology of acute intermittent porphyria, which is transmitted as autosomal dominant disorders with incomplete penetrance. Other chapters consider the main characteristics of congenital erythropoietic porphyria, which includes an increased synthesis, accumulation, ad excretion of porphyrins. This book discusses as well the biochemistry, pathophysiology, and clinical features of variegate porphyria in the light of several essential advances in the understanding, management, and diagnosis of variegate porphyria. The final chapter deals with the legal use of herbal and complementary medicines. This book is a valuable resource for research scientists, engineers, and clinicians.
Author: Dolph L. Hatfield
Publisher: CRC Press
ISBN: 1351094297
Category : Medical
Languages : en
Pages : 340
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Book Description
Transfer RNA in Protein Synthesis is a comprehensive volume focusing on important aspects of codon usage, selection, and discrimination in the genetic code. The many different functions of tRNA and the specialized roles of the corresponding codewords in protein synthesis from initiation through termination are thoroughly discussed. Variations that occur in the initiation process, in reading the genetic code, and in the selection of codons are discussed in detail. The book also examines the role of modified nucleosides in tRNA interactions, tRNA discrimination in aminoacylation, codon discrimination in translation, and selective use of termination codons. Other topics covered include the adaptation of the tRNA population to codon usage in cells and cellular organelles, the occurence of UGA as a codon for selenocysteine in the universal genetic code, new insights into translational context effects and in codon bias, and the molecular biology of tRNA in retroviruses. The contributions of outstanding molecular biologists engaged in tRNA research and prominent investigators from other scientific disciplines, specifically retroviral research, make Transfer RNA in Protein Synthesis an essential reference work for microbiologists, biochemists, molecular biologists, geneticists, and other researchers involved in protein synthesis research.
Author: J. Lemontt
Publisher: Springer Science & Business Media
ISBN: 1461334764
Category : Science
Languages : en
Pages : 391
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Book Description
It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Virtually no facilities were available and most of the wartime scientists had left. So, when we started out, it was obvious to me that something had to be done to reestab lish research. Even more, because Oak Ridge was not known at that time for its biological work but rather for the separation of Uranium 235, nuclear reactor development, and radioisotope produc tion, a new tradition had to be promoted. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained. When we started the work of the Biology Division, it became essential to make it part of the flow of mod~rn biology allover the world. As Director, I had to do more than just attract promising scientists. We created an atmosphere conducive to creative research and nurtured all of the other aspects of a productive laboratory. Of course, we carefully prepared the results of our work in publish able form. We made a sincere effort to invite seminar speakers and lecturers to come to Oak Ridge despite the sacrifices this presented to our early budget. We also had to do something more, and here I "cashed in" on my experience of the previous 15 years.
Author: Diana J Vincent
Publisher: World Scientific
ISBN: 9814548332
Category :
Languages : en
Pages : 1630
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Book Description
This three volume series represents a selected and refereed collection of papers contributed by the participants of the First World Congress on Computational Medicine, Public Health, and Biotechnology, held in 1994 at Austin, Texas. Over 500 individuals, from 30 countries attended this meeting. In addition, this collection contains a number of papers from the Australian CSIRO High Performance Computing Meeting held that same year.
Author: K. Tanaka
Publisher: Springer Science & Business Media
ISBN: 4431788476
Category : Medical
Languages : en
Pages : 650
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Book Description
Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.
