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Author: Lane B. Scheiber II MD
Publisher: iUniverse
ISBN: 1491744553
Category : Medical
Languages : en
Pages : 262
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Book Description
The world is under constant threat of a virus evolving into a global plague.To this point, there is no direct defense against a widespread viral infection. Fourth Generation Biologics: Molecular Virus Killers offers an innovative, new strategy to combat deadly viral infections. Presented is the discovery of unique identifiers for the viral scourges: HIV, Herpes Simplex, the Shingles virus, the Smallpox virus and the newly emerging threats of Ebola virus and the Chikungunya virus. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear signaling proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites is undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This emerging technology is then extrapolated to explore activating therapeutic nuclear genes to treat challenging medical conditions including diabetes and osteoarthritis.
Author: Lane B. Scheiber II MD
Publisher: iUniverse
ISBN: 1491744553
Category : Medical
Languages : en
Pages : 262
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Book Description
The world is under constant threat of a virus evolving into a global plague.To this point, there is no direct defense against a widespread viral infection. Fourth Generation Biologics: Molecular Virus Killers offers an innovative, new strategy to combat deadly viral infections. Presented is the discovery of unique identifiers for the viral scourges: HIV, Herpes Simplex, the Shingles virus, the Smallpox virus and the newly emerging threats of Ebola virus and the Chikungunya virus. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear signaling proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites is undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This emerging technology is then extrapolated to explore activating therapeutic nuclear genes to treat challenging medical conditions including diabetes and osteoarthritis.
Author: Lane Scheiber
Publisher: iUniverse
ISBN: 1532017227
Category : Medical
Languages : en
Pages : 308
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Book Description
The world is under constant threat of a virus evolving into a global plague. To this point, there is no direct defense against a widespread viral infection. DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. Presented is the discovery of a unique identifier for HIV. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear transcription factor proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites are undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This text describes the design of an intracellular courier gene technology to make cells defensible against HIV and other lethal pathogenic viral threats.
Author: Lane B. Scheiber II MD
Publisher: iUniverse
ISBN: 1532071507
Category : Science
Languages : en
Pages : 361
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Book Description
The luminous aether, a concept known for hundreds of years, is the fine essence of the universe. Over the last 130 years, mainstream science abandoned the knowledge such an aether existed. Yet, reawakening the principles of a luminous aether as the fabric of space--both within our being and surrounding us, reaching out in every direction to the very edges of the universe-- explains many unsolved mysteries. The luminous aether is a vast three-dimensional ocean of the tiniest and most elemental particles called quadsitrons. From the fusion of quadsitrons and energy, all else in the universe is constructed. The dynamics of quadsitrons interacting with energy accounts for and connects all the micro and macrophenomena that fill our lives, such as gravity, light, electrons, atoms, molecules, and magnetism. It is essential we understand and grasp the principles of this wondrous quadsitron-energy connectivity in order to advance our technology forward to interstellar travel.
Author: Sunit K. Singh
Publisher: Springer
ISBN: 3030030717
Category : Medical
Languages : en
Pages : 388
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Book Description
This second volume of a two-volume set focuses on specific pathogens and their mechanisms of pathogenesis as well as diagnostics, therapeutics and various strategies in the event of biological attacks. This multidisciplinary book appeals to readers from various fields, including biodefense, biosafety & biosecurity, virology, neurology, molecular biology and genetic engineering, as well as infectious disease specialists. Further, the work is of interest to basic science and applied science research scholars and experts working in the area of high-consequence or select agent virology.
Author: Lane B. Scheiber II MD
Publisher: iUniverse
ISBN: 1663208409
Category : Medical
Languages : en
Pages : 198
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Book Description
The world is on fire, threatened by a global pandemic brought on by COVID-19. This virulent viral pathogen has rapidly infected every continent across the globe and has spread misery and death in its wake. COVID-19 is very efficient, carrying in its genetic code the instructions to construct its own personal replication machinery. This virus is very effective at copying itself, but does so with a relatively high rate of mutation to the genetic code. Given Coronavirus exhibits a frequent rate of alteration to its state, resulting in an elusive adversary, which makes treating with traditional vaccines an ongoing challenge. Fighting back with novel mRNA therapies, which can be rapidly redesigned, may offer an effective broad-spectrum therapeutic armamentarium to combat Coronavirus. Modification of the native human CD8 cell surface receptor to alert the immune system to the possible presence of the COVID-19, can result in early development of antibodies to target the pathogen. But taking the fight directly to the virus, to stop the infection in an afflicted person, is the next necessary technologic leap in pharmaceutical medicine. Redesigning native human transcription factors to create a hunter-killer protein to neutralize the COVID-19 genome is the next critical innovation necessary to eradicate viral pandemics. Cultivating a cure to counteract viral infections such as Coronavirus is now more essential than ever. Ebola, a devastatingly hostile viral infection, sits lurking, in wait. At the point Ebola evolves into an airborne viral entity, the consequences of such a noxious global pandemic will be horrific. The time is now, to secure versatile and effective vaccines and devise an effective cure to stop rampant viral infections, such as Coronavirus and Ebola.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1376
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Author: David W. Kingsbury
Publisher: Springer Science & Business Media
ISBN: 1461537908
Category : Medical
Languages : en
Pages : 608
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Book Description
What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil lions annually. There are many pathogenic paramyxoviruses and too few effec tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.
Author: Denis Archambault
Publisher: Frontiers Media SA
ISBN: 2832532543
Category : Medical
Languages : en
Pages : 128
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Book Description
Emerging and re-emerging infections, in particular those caused by viruses, are expected to rise in correlation, among other factors, with climate changes. Antibiotic resistance is another issue that will limit the therapeutic arsenal against bacterial and parasitic infections. Therefore, one must be adequately prepared to overcome and prevent current and novel infections, and vaccination remains the optimal way to fight infectious diseases in humans. This is also true for many impacting diseases of livestock and companion animals, to which there are no available vaccines. First (attenuated and inactivated) and second (subunit) generation vaccines have their limitations. To overcome this, efforts have been made in recent years to develop novel vaccine types such as virus-like particle (VLP)-, viral vector-, and DNA-based vaccines in humans and animals. The recent success in utilizing RNA technology based-vaccines to fight SARS-CoV-2 to limit the severity of clinical symptoms and mortality constitutes a promising way to develop such vaccines against animal diseases. Development of novel molecules or materials with adjuvant or immunostimulatory activity to adequately stimulate the innate immune response, and, therefore the pathogen-specific adaptative immune response, as well as the identification of suitable antigenic material that would bring broad protection against infectious agent variants are other key issues to be considered in developing safe and innovative immunization strategies.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1060
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