The Retardation of Aging and Disease by Dietary Restriction

The Retardation of Aging and Disease by Dietary Restriction PDF Author: Richard Weindruch
Publisher: Charles C Thomas Pub Limited
ISBN: 9780398054960
Category : Health & Fitness
Languages : en
Pages : 436

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Book Description

The Retardation of Aging and Disease by Dietary Restriction

The Retardation of Aging and Disease by Dietary Restriction PDF Author: Richard Weindruch
Publisher: Charles C Thomas Pub Limited
ISBN: 9780398054960
Category : Health & Fitness
Languages : en
Pages : 436

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Book Description


Developmental Genetics of the Pharyngeal Arch System

Developmental Genetics of the Pharyngeal Arch System PDF Author: Jeffry M. Cesario
Publisher: Biota Publishing
ISBN: 161504681X
Category : Science
Languages : en
Pages : 120

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Book Description
The pharyngeal arches are embryonic structures that develop into the face, neck, a part of the heart, and several endocrine glands in animals. They are thought to have played a key role in vertebrate evolution as their derivatives impact the mode of feeding and breathing. Moreover, perturbation in pharyngeal arch development is associated with several major groups of birth defects in humans. During early embryonic development, cells from all three germ layers come together to assemble the pharyngeal arches. Subsequently, the pharyngeal arches undergo growth, morphogenesis, and cell type differentiation to give rise to musculoskeletal, cardiovascular, neural, and glandular components. These processes are guided by interactions amongst different tissues, via signaling molecules. A large number of genes, with a complex network of regulatory relationships, govern each aspect of pharyngeal arch development. With the advance of molecular genetics tools in model organisms such as mice, we are beginning to understand the molecular and cellular mechanisms underlying development of the pharyngeal arches and related birth defects. This eBook will provide an introduction into development of the pharyngeal arch system, with a detailed discussion on the genetic regulation of this process.

Gonadotropins: From Bench Side to Bedside

Gonadotropins: From Bench Side to Bedside PDF Author: Rajendra T. Kumar
Publisher: Academic Press
ISBN: 0128012668
Category : Medical
Languages : en
Pages : 232

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Book Description
Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. - Contains contributions from leading authorities on the topic - Publishes cutting-edge reviews in molecular biology - Informs and updates on all the latest developments available regarding the research of gonadotropins

Sertoli Cell Biology

Sertoli Cell Biology PDF Author: Michael D. Griswold
Publisher: Academic Press
ISBN: 012417048X
Category : Science
Languages : en
Pages : 488

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Book Description
Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years

Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression PDF Author: Martin L. Privalsky
Publisher: Springer Science & Business Media
ISBN: 9783540676119
Category : Medical
Languages : en
Pages : 218

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Book Description
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Transforming Growth Factor-Beta in Cancer Therapy, Volume I PDF Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
ISBN: 1588297144
Category : Medical
Languages : en
Pages : 726

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Book Description
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Mechanisms of Gene Regulation: How Science Works

Mechanisms of Gene Regulation: How Science Works PDF Author: Carsten Carlberg
Publisher: Springer Nature
ISBN: 3030523217
Category : Medical
Languages : en
Pages : 160

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Book Description
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

A Handbook of Transcription Factors

A Handbook of Transcription Factors PDF Author: Timothy R. Hughes
Publisher: Springer Science & Business Media
ISBN: 904819069X
Category : Medical
Languages : en
Pages : 310

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Book Description
Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Gene Regulation in Eukaryotes

Gene Regulation in Eukaryotes PDF Author: Edgar Wingender
Publisher: Wiley-Blackwell
ISBN:
Category : Science
Languages : en
Pages : 452

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Book Description
A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.

Poly(ADP-Ribosyl)ation

Poly(ADP-Ribosyl)ation PDF Author: Alexander Bürkle
Publisher: Springer Science & Business Media
ISBN: 0387360050
Category : Medical
Languages : en
Pages : 260

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Book Description
This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.