Toxicological Profile for Bis(chloromethyl)ether PDF Download
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Author:
Publisher:
ISBN:
Category : Dichloromethyl ether
Languages : en
Pages : 78
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Book Description
Author:
Publisher:
ISBN:
Category : Dichloromethyl ether
Languages : en
Pages : 78
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Book Description
Author: National Institute for Occupational Safety and Health
Publisher:
ISBN:
Category :
Languages : en
Pages : 596
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Book Description
Author: Dow Chemical Company
Publisher:
ISBN:
Category : Chemical industry
Languages : en
Pages : 16
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Book Description
Author: Samuel S. Epstein
Publisher: Random House (NY)
ISBN:
Category : Medical
Languages : en
Pages : 610
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Book Description
Discusses the wide range of human cancers that are environmentally induced or related and presents suggestions on how many cancers can be prevented by controlling environmental factors.
Author: United States. Congress. House. Committee on Government Operations. Subcommittee on Government Information and Individual Rights
Publisher:
ISBN:
Category : Government information
Languages : en
Pages : 1066
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Book Description
Author:
Publisher:
ISBN:
Category : Char
Languages : en
Pages : 1040
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Book Description
Author: Bureau of National Affairs (Arlington, Va.)
Publisher:
ISBN:
Category : Administrative law
Languages : en
Pages : 1182
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Book Description
Author: CCH Incorporated
Publisher: CCH Incorporated
ISBN: 9780808014386
Category : Business & Economics
Languages : en
Pages : 878
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Book Description
Author: CCH Incorporated
Publisher: CCH Incorporated
ISBN: 9780808017295
Category : Business & Economics
Languages : en
Pages : 934
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Book Description
Author: Andrew Teasdale
Publisher: John Wiley & Sons
ISBN: 1119551218
Category : Medical
Languages : en
Pages : 548
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Book Description
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
