Tissue-Engineered Vascular Grafts PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Tissue-Engineered Vascular Grafts PDF full book. Access full book title Tissue-Engineered Vascular Grafts by Beat H. Walpoth. Download full books in PDF and EPUB format.
Author: Beat H. Walpoth
Publisher: Springer
ISBN: 9783030053352
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Author: Beat H. Walpoth
Publisher: Springer
ISBN: 9783030053352
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
Get Book Here
Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: TJ Bunt
Publisher: Wiley-Blackwell
ISBN: 9780879935764
Category : Medical
Languages : en
Pages : 420
Get Book Here
Book Description
Vascular graft infection is a complex and challenging problem for the vascular surgeon. Despite significant advances that have been made in managing patient problems associated with graft infection during the last 25 years, the topic of vascular graft infection has been only loosely covered in various textbooks. Fortunately, this monograph fills this void of information by offering a wealth of useful, clearly organized clinical knowledge
Author: Sigmund Adam Wesolowski
Publisher:
ISBN:
Category : Blood vessel prosthesis
Languages : en
Pages : 192
Get Book Here
Book Description
Author: Julian Chaudhuri
Publisher: Springer Science & Business Media
ISBN: 1402037414
Category : Medical
Languages : en
Pages : 373
Get Book Here
Book Description
For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.
Author: Andreas F von Recum
Publisher: CRC Press
ISBN: 9781560324799
Category : Medical
Languages : en
Pages : 944
Get Book Here
Book Description
This handbook addresses the needs of those who are involved in inventing, developing, and testing implants and are concerned about the interactions between biomaterial and body tissue. The authors explore the physical, chemical, mechanical and regulatory considerations of synthetic materials used in surgical and implant procedures, and how these factors impact the latest developments and new approaches. This updated edition provides the biomaterials professional with necessary information on a range of issues, including bulk characterization, surface evaluations, toxicological evaluations, in vitro methods for safety evaluation, methods for evaluating materials in special applications, surgical considerations, systems implantology, soft and hard tissue history, regulatory aspects, and clinical trials.
Author: Kazuo Tanishita
Publisher: Springer
ISBN: 4431548017
Category : Medical
Languages : en
Pages : 400
Get Book Here
Book Description
This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Author: The National Academies
Publisher: National Academies Press
ISBN: 0309104661
Category : Medical
Languages : en
Pages : 140
Get Book Here
Book Description
The 2006 conference, "Smart Prosthetics: Exploring Assistive Devices for the Body and Mind," attracted scientists, engineers and medical researchers to participate in a series of task groups to develop research plans to address various challenges within the prosthetics field. Eleven conference task groups gave the participants eight hours to develop new research approaches to various challenges, including: build a smart prosthesis that will grow with a child; develop a smart prosthetic that can learn better and/or faster; refine technologies to create active orthotic devices; and describe a framework for replacing damaged cortical tissue and fostering circuit integration to restore neurological function. Representatives from public and private funding organizations, government, industry, and the science media also participated in the task groups. This book provides a summary of the conference task groups. For more information about the conference, visit the Smart Prosthetics conference site. The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. The National Academies and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions upon which they can base entirely new research, and to encourage better communication between scientists as well as between the scientific community and the public. Funded by a $40 million grant from the W.M. Keck Foundation, the National Academies Keck Futures Initiative is a 15-year effort to catalyze interdisciplinary inquiry and to enhance communication among researchers, funding agencies, universities, and the general public with the object of stimulating interdisciplinary research at the most exciting frontiers. The Futures Initiative builds on three pillars of vital and sustained research: interdisciplinary encounters that counterbalance specialization and isolation; the identification and exploration of new research topics; and communication that bridges languages, cultures, habits of thought, and institutions. Toward these goals, the National Academies Keck Futures Initiative incorporates three core activities each year: Futures conferences, Futures grants, and National Academies Communication Awards. For more information about the Initiative, visit www.keckfutures.org.
Author: Michael Sonick
Publisher: John Wiley & Sons
ISBN: 0470963190
Category : Medical
Languages : en
Pages : 862
Get Book Here
Book Description
With the desire for dental implant therapy ever escalating, clinicians are faced with the challenge of augmenting deficient natural physiology to provide effective sites for implantation. Implant Site Development helps the clinician decide if, when, and how to create a ridge site amenable to implantation. This practical book offers solutions to many implant site preservation scenarios, discussing different treatment options, timing, a variety of materials and techniques, and their application to the clinical practice. With a unique integrated clinical approach, Implant Site Development covers a range of site development techniques. Highly illustrated, Implant Site Development presents diagrams and clinical photographs to aid with clinical judgment and will prove useful for any dental professional involved in implant therapy, from general practitioners to prosthodontists, but especially surgeons. This literature-based, yet user-friendly, reference will be indispensable to the novice or veteran clinician.
Author: Jamal J. Hoballah
Publisher: Springer Science & Business Media
ISBN: 038798500X
Category : Medical
Languages : en
Pages : 400
Get Book Here
Book Description
This must-have manual for surgical residents and vascular surgery trainees is copiously illustrated with more than 250 original line drawings. The author presents in a step-by-step fashion the techniques for all common vascular reconstructions, basics of exposure and access, as well as invaluable technical pearls and tips. The text provides the surgical trainee with the opportunity to review and practice the necessary vascular reconstructions before entering the operating room. The illustrations and clear instructions make this a manual that is referred to again and again throughout the surgical residency.
