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Author: Christophe Wiart
Publisher: Springer Science & Business Media
ISBN: 1597451606
Category : Medical
Languages : en
Pages : 236
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Book Description
In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.
Author: Christophe Wiart
Publisher: Springer Science & Business Media
ISBN: 1597451606
Category : Medical
Languages : en
Pages : 236
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Book Description
In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.
Author: Jayanta Kumar Patra
Publisher: CRC Press
ISBN: 0429675372
Category : Health & Fitness
Languages : en
Pages : 454
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Book Description
Ethnopharmacology and Biodiversity of Medicinal Plants provides a multitude of contemporary views on the diversity of medicinal plants, discussing both their traditional uses and therapeutic claims. This book emphasizes the importance of cataloging ethnomedical information as well as examining and preserving the diversity of traditional medicines. It also discusses the challenges present with limited access to modern medicine and the ways in which research can be conducted to enhance these modern practices. The book also explores the conservation procedures for endangered plant species and discusses their relevance to ethnopharmacology. Each chapter of this book relays the research of experts in the field who conducted research in diverse landscapes of India, providing a detailed account of the basic and applied approaches of ethnobotany and ethnopharmacology. The book reviews multiple processes pertaining to medicinal plants, such as collecting the traditional therapeutic values and validation methods. It also explores developments in the field such as the diversity and medicinal potential of unexplored plant species and applications in drug formulation to fight against anti-microbial resistance (AMR).
Author: Michael Heinrich
Publisher: John Wiley & Sons
ISBN: 1118930738
Category : Medical
Languages : en
Pages : 464
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Book Description
Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org
Author: Gerard Marshall Raj
Publisher: Springer Nature
ISBN: 9813297794
Category : Medical
Languages : en
Pages : 410
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Book Description
This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Author: Christophe Wiart
Publisher: CRC Press
ISBN: 1351737120
Category : Science
Languages : en
Pages : 303
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Book Description
Medicinal Plants of Bangladesh and West Bengal is a complete compendium. It provides the scientific name, classification, local name(s), historical background, local medicinal uses, botanical description, chemical constituents, pharmacological activity and toxicology of more than 100 medicinal spices used in Bengal. Chemical structures of active constituents are provided as well as numerous references. This book is an indispensable tool for researchers, as well as graduates in various disciplines, including pharmacy, pharmacology, medicine, biotechnology, nutrition, cosmetology and drug development. It is also suitable for anyone who is looking for natural products as leads to be developed in therapeutics, functional nutrition or cosmetology. Focuses on a group of herbs with economic importance – the spices. These herbs demonstrate the richness of chemical diversity and potential pharmacological applications Features field photos with local healers, markets and mode of preparation as well as providing a complete monograph for each plant Discusses the collection and observation of each medicinal spice and presents the ethnopharmacology recorded by the author in Bengal Provides a wealth of scientific information on medicinal spices from an expert in the field Fills an important niche due to the increasing global interests in natural foods and botanical drugs
Author: Bharat Singh
Publisher: John Wiley & Sons
ISBN: 3527825584
Category : Technology & Engineering
Languages : en
Pages : 1562
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Book Description
Covers the structurally diverse secondary metabolites of medicinal plants, including their ethnopharmacological properties, biological activity, and production strategies Secondary metabolites of plants are a treasure trove of novel compounds with potential pharmaceutical applications. Consequently, the nature of these metabolites as well as strategies for the targeted expression and/or purification is of high interest. Regarding their biological and pharmacological activity and ethnopharmacological properties, this book offers a comprehensive treatment of 100 plant species, including Abutilon, Aloe, Cannabis, Capsicum, Jasminum, Malva, Phyllanthus, Stellaria, Thymus, Vitis, Zingiber, and more. It also discusses the cell culture conditions and various strategies used for enhancing the production of targeted metabolites in plant cell cultures. Secondary Metabolites of Medicinal Plants: Ethnopharmacological Properties, Biological Activity and Production Strategies is presented in four parts. Part I provides a complete introduction to the subject. Part II looks at the ethnomedicinal and pharmacological properties, chemical structures, and culture conditions of secondary metabolites. The third part examines the many strategies of secondary metabolites production, including: biotransformation; culture conditions; feeding of precursors; genetic transformation; immobilization; and oxygenation. The last section concludes with an overview of everything learned. -Provides information on cell culture conditions and targeted extraction of secondary metabolites confirmed by relevant literature -Presents the structures of secondary metabolites of 100 plant species together with their biological and pharmacological activity -Discusses plant species regarding their distribution, habitat, and ethnopharmacalogical properties -Presents strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis Secondary Metabolites of Medicinal Plants is an important book for students, professionals, and biotechnologists interested in the biological and pharmacological activity and ethnopharmacological properties of plants.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470514019
Category : Science
Languages : en
Pages : 254
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Book Description
Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to environmental factors. The isolation and characterization of plant products, the identification of their role in the plant, and ways of synthesizing identical compounds or more potent analogues are covered. Also includes methods of culturing plant tissues and genetic engineering as a means of increasing the yield of desired substances from plants. Special emphasis is placed on plants previously unknown to Western scientists.
Author: Milan S. Stankovic
Publisher: MDPI
ISBN: 3039281186
Category : Science
Languages : en
Pages : 232
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Book Description
The book entitled Medicinal Plants and Natural Product Research describes various aspects of ethnopharmacological uses of medicinal plants; extraction, isolation, and identification of bioactive compounds from medicinal plants; various aspects of biological activity such as antioxidant, antimicrobial, anticancer, immunomodulatory activity, etc., as well as characterization of plant secondary metabolites as active substances from medicinal plants.
Author: Amritpal Singh
Publisher: CRC Press
ISBN: 1439853614
Category : Health & Fitness
Languages : en
Pages : 419
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Book Description
Bridging the gap between the ancient art of herbalism and the emerging sciences of ethnopharmocology and phytopharmacotherapy, this book highlights the major breakthroughs in the history of the field and focuses on future directions in the discovery and application of herb-derived medicines. Implementing the concept of reverse pharmacology, it inte
Author: Elisabeth Hsu
Publisher: Berghahn Books
ISBN: 0857456334
Category : Health & Fitness
Languages : en
Pages : 321
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Book Description
Plants have cultural histories, as their applications change over time and with place. Some plant species have affected human cultures in profound ways, such as the stimulants tea and coffee from the Old World, or coca and quinine from South America. Even though medicinal plants have always attracted considerable attention, there is surprisingly little research on the interface of ethnobotany and medical anthropology. This volume, which brings together (ethno-)botanists, medical anthropologists and a clinician, makes an important contribution towards filling this gap. It emphasises that plant knowledge arises situationally as an intrinsic part of social relationships, that herbs need to be enticed if not seduced by the healers who work with them, that herbal remedies are cultural artefacts, and that bioprospecting and medicinal plant discovery can be viewed as the epitome of a long history of borrowing, stealing and exchanging plants.
