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Author: Ahmet Höke
Publisher: Springer Science & Business Media
ISBN: 0387300112
Category : Medical
Languages : en
Pages : 226
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Book Description
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
Author: Ahmet Höke
Publisher: Springer Science & Business Media
ISBN: 0387300112
Category : Medical
Languages : en
Pages : 226
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Book Description
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
Author: Arthur J. Sytkowski
Publisher: Wiley-Blackwell
ISBN: 9783527304950
Category : Science
Languages : en
Pages : 0
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Book Description
The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
Author: Ajay K. Singh
Publisher: Academic Press
ISBN: 0080920462
Category : Medical
Languages : en
Pages : 534
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Book Description
The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. - Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems - Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work - Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field
Author: John W. Harvey
Publisher: Elsevier Health Sciences
ISBN: 1437723608
Category : Medical
Languages : en
Pages : 370
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Book Description
Combining essential hematology content with the diagnostic features of an atlas, Veterinary Hematology: A Diagnostic Guide and Color Atlas delivers all the information you need to accurately assess and diagnose the blood diseases of common domestic animals — including dogs, cats, horses, cattle, sheep, goats, pigs, and llamas. This all-in-one resource utilizes a clinically-oriented and user-friendly approach to guide you through the processes of selecting relevant diagnostic tests, collecting and preparing samples, interpreting sample results, and determining their clinical significance. High-resolution photomicrographs, full-color illustrations, and excellent schematic drawings, tables, and quick-reference algorithms help you clearly visualize these concepts and procedures. Two books in one gives you the information of a user-friendly, clinical textbook and the diagnostic features of a color atlas in a single reference. Practical, clinically-relevant text is comprehensive and yet concise in its delivery of vital information such as: Principles and procedures that are employed in recognizing normal, abnormal, and artifactual features of blood and bone marrow samples and developing accurate diagnoses Common cytochemical stains and summary charts for interpretation Sample collection, staining procedures, and diagnostic techniques Differentiating features of malignant and benign hematologic disorders Miscellaneous cells and blood parasites and their significance in the evaluation of blood smears Hematopoietic and non-hematopoietic neoplasms High- resolution photomicrographs and excellent schematic drawings, tables, boxes and quick-reference algorithms aid your understanding of basic clinical concepts and differential diagnostic considerations. Over 800 full-color illustrations help you clearly visualize the concepts and clinical features of the blood and bone marrow — from normal cell maturation to the development of various pathologies.
Author: American Psychiatric Association
Publisher: American Psychiatric Pub
ISBN: 1585627879
Category : Medical
Languages : en
Pages : 364
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Book Description
Since the development of pharmacoconvulsive therapy in 1934 and of electroconvulsive therapy (ECT) in 1938, ECT has proven far more valuable than just the intervention of last resort. In comparison with psychotropic medications, we now know that ECT can act more effectively and more rapidly, with substantial clinical improvement that is often seen after only a few treatments. This is especially true for severely ill patients -- those with severe major depression with psychotic features, acute mania with psychotic features, or catatonia. For patients who are physically debilitated, elderly, or pregnant, ECT is also safer than psychotropic medications. The findings of the American Psychiatric Association (APA) Task Force on ECT were published by the APA in 1990 as the first edition of The Practice of Electroconvulsive Therapy, inaugurating the development of ECT guidelines by groups both within the United States and internationally. Since then, advances in the use of this technically demanding treatment prompted the APA to mandate a second edition. The updated format of this second edition presents background information followed by a summary of applicable recommendations for each chapter. This close integration of the recommendations with their justifications makes the material easy to read, understand, and use. To further enhance usability, recommendations critical to the safe, effective delivery of treatment are marked with the designation "should" to distinguish them from recommendations that are advisable but nonessential (with the designations "encouraged," "suggested," "considered"). The updated content of this second edition, which spans indication for use of ECT, patient evaluation, side effects, concurrent medications, consent procedures (with sample consent forms and patient information booklet), staffing, treatment administration, monitoring of outcome, management of patients following ECT, and documentation, as well as education, and clinical privileging. This volume reflects not only the wide expertise of its contributors, but also involved solicitation of input from a variety of other sources, including applicable medical professional organizations, individual experts in relevant fields, regulatory bodies, and major lay mental health organizations. In addition, the bibliography of this second edition is based upon an exhaustive search of the clinical ECT literature over the past decade and contains more than four times the original number of citations. Complemented by extensive annotations and useful appendixes, this remarkably comprehensive yet practical overview will prove an invaluable resource for practitioners and trainees in psychiatry and related disciplines.
Author: Pietro Ghezzi
Publisher: Humana Press
ISBN: 9781627033077
Category : Science
Languages : en
Pages : 0
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Book Description
While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: David Grundy
Publisher:
ISBN: 9780470721308
Category :
Languages : en
Pages : 97
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Book Description
Substantially rewritten to include the most recent developments in the practical management of patients with potential spine injury and risk minimization techniques, this fourth edition also has a chapter on spinal cord injury in developing countries.
Author: Arthur J. Sytkowski
Publisher: John Wiley & Sons
ISBN: 3527605436
Category : Science
Languages : en
Pages : 237
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Book Description
The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
Author:
Publisher: Academic Press
ISBN: 0128122668
Category : Medical
Languages : en
Pages : 353
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Book Description
Erythropoietin, Volume 105, the latest release in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. Topics covered in this new volume include Erythropoietin Receptor Structural Domains, Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists, Endogenous Erythropoietin, Erythropoietin Receptor Signaling and Lipid Rafts, and Erythropoietin and Hypothalamic-Pituitary Axis. Each thoroughly reviewed volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors and others. This volume documents the activities of this vital molecule, also describing the structure and function of erythropoietin and its receptor. - Presents the latest information on erythropoietin - Provides a long-running series that focuses on updates and advances in vitamins and hormones - Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances
