Epidemiology of Cancer of the Digestive Tract PDF Download
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Author: Pelayo Correa
Publisher: Springer Science & Business Media
ISBN: 9400975023
Category : Medical
Languages : en
Pages : 267
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Book Description
The digestive organs are the most frequent site of cancer in the world, accounting for approximately 30% of all malignant tumors. This prominent position has been present for many decades in spite of marked shifts in the freq uency of cancer of specific organs. The most remarkable shift has been the decrease in gastric cancer rates occurring concomitantly with an increase in colon cancer rates in most 'western' industrialized societies. Important exceptions to this rule, as well as other epidemiologic evidence, indicate that the opposite trends for gastric and colon cancers are not inevitable consequences of each other. Although genetic ally determined precancerous syndromes are well recognized, it is generally agreed that environmental factors play an overriding role in digestive cancer causation. The most obvious environmental factors seem to be the result of what we eat, drink, or smoke. Although the nutritional component of the diet is of unquestionable importance, the nonnutrient elements in our diet have also proven to be influential causative factors. Several studies have focused on the microenvironment at the level of the mucosa or the digestive organs as a micro cosmos where forces promoting and inhibiting carcinogenesis are operating for a prolonged period of time. Their interaction eventually determines the presence or absence of a malignant tumor. Our understanding of such modulating forces, hopefully, will someday allow us to modify the microenvironment in a favorable way and attain the goal of cancer prevention.
Author: Pelayo Correa
Publisher: Springer Science & Business Media
ISBN: 9400975023
Category : Medical
Languages : en
Pages : 267
Get Book Here
Book Description
The digestive organs are the most frequent site of cancer in the world, accounting for approximately 30% of all malignant tumors. This prominent position has been present for many decades in spite of marked shifts in the freq uency of cancer of specific organs. The most remarkable shift has been the decrease in gastric cancer rates occurring concomitantly with an increase in colon cancer rates in most 'western' industrialized societies. Important exceptions to this rule, as well as other epidemiologic evidence, indicate that the opposite trends for gastric and colon cancers are not inevitable consequences of each other. Although genetic ally determined precancerous syndromes are well recognized, it is generally agreed that environmental factors play an overriding role in digestive cancer causation. The most obvious environmental factors seem to be the result of what we eat, drink, or smoke. Although the nutritional component of the diet is of unquestionable importance, the nonnutrient elements in our diet have also proven to be influential causative factors. Several studies have focused on the microenvironment at the level of the mucosa or the digestive organs as a micro cosmos where forces promoting and inhibiting carcinogenesis are operating for a prolonged period of time. Their interaction eventually determines the presence or absence of a malignant tumor. Our understanding of such modulating forces, hopefully, will someday allow us to modify the microenvironment in a favorable way and attain the goal of cancer prevention.
Author: F. T. Bosman
Publisher: International Agency for Research on Cancer
ISBN:
Category : Medical
Languages : en
Pages : 424
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Book Description
"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].
Author: P. Hohenberger
Publisher: Springer Science & Business Media
ISBN: 3642562906
Category : Medical
Languages : en
Pages : 206
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Book Description
Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.
Author: Jae Bock Chung
Publisher: Springer Nature
ISBN: 9811560102
Category : Medical
Languages : en
Pages : 300
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Book Description
This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.
Author: U. Metzger
Publisher: Springer Science & Business Media
ISBN: 3642824323
Category : Medical
Languages : en
Pages : 170
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Book Description
One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.
Author: Vivian E. Strong
Publisher: Springer
ISBN: 3319158260
Category : Medical
Languages : en
Pages : 331
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Book Description
This volume provides the most comprehensive and complete resource available on all aspects of gastric cancer and it’s management. The book covers topics such as oncologic approaches to staging, treating, and following patients, filling a critical need for resource materials on these areas. As multidisciplinary care is an integral part of gastric cancer treatment, this text is unique in including a renowned group of expert authors from a variety of disciplines, including pathology, gastroenterology, medical oncology, surgery and clinical genetics. In addition, authors from an international pool of gastric cancer experts have covered the breadth of practice and understanding globally. Edited and organized by an expert from one of the most highly respected cancer institutions in the country, Gastric Cancer: Principles and Practice is an expert review of this field, serving as a valuable reference for physicians in training and in practice, as well as for researchers who are interested in the scope of issues and advances in this important malignancy.
Author: Suayib Yalcin
Publisher: Springer Nature
ISBN: 3030188906
Category : Medical
Languages : en
Pages : 711
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Book Description
This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309101697
Category : Medical
Languages : en
Pages : 341
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Book Description
In conjunction with drafting comprehensive legislation concerning compensation for health effects related to asbestos exposure (the Fairness in Asbestos Injury Act), the Senate Committee on the Judiciary directed the Institute of Medicine to assemble the Committee on Asbestos: Selected Health Effects. This committee was charged with addressing whether asbestos exposure is causally related to adverse health consequences in addition to asbestosis, mesothelioma, and lung cancer. Asbestos: Selected Cancers presents the committee's comprehensive distillation of the peer-reviewed scientific and medical literature regarding association between asbestos and colorectal, laryngeal, esophageal, pharyngeal, and stomach cancers.
Author:
Publisher: Academic Press
ISBN: 0128160764
Category : Medical
Languages : en
Pages : 1656
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Book Description
Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years
Author: Paul H. Sugarbaker
Publisher: Springer Science & Business Media
ISBN: 1461538823
Category : Medical
Languages : en
Pages : 405
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Book Description
Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.
