Cancer and the Environment

Cancer and the Environment PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309169240
Category : Science
Languages : en
Pages : 160

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Book Description
The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Cancer and the Environment

Cancer and the Environment PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309169240
Category : Science
Languages : en
Pages : 160

Get Book Here

Book Description
The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Saving Women's Lives

Saving Women's Lives PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309165946
Category : Medical
Languages : en
Pages : 384

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Book Description
The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Oral Contraceptives and Breast Cancer

Oral Contraceptives and Breast Cancer PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309044936
Category : Medical
Languages : en
Pages : 196

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Book Description
At least 10.7 million American women use oral contraceptives (OCs). The potential connection with breast cancer has caused concern among these OC users and uncertainty among many of their physicians. This new volume offers the most up-to-date information available on this critical topic. While the best available knowledge does not support any fundamental change in clinical practice with respect to the use of OCs, this book offers specific recommendations for more research to fully resolve the relationship between OCs and breast cancer. Noting consumer confusion, the volume includes a concise summary of benefits, risks, and other practical information for contraceptive users and their doctors. The volume presents current data on changes in patterns of OC use, differences in risk at different ages, the benefits of OCs, and more. Oral Contraceptives and Breast Cancer will be important reading for obstetricians/gynecologists and other health professionals, their patients who use OCs, contraceptive manufacturers, women's health advocates, policymakers, and researchers.

The Falling Age of Puberty in U.S. Girls

The Falling Age of Puberty in U.S. Girls PDF Author: Sandra Steingraber
Publisher:
ISBN:
Category : Child development
Languages : en
Pages : 72

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Book Description


Breast Cancer and the Environment

Breast Cancer and the Environment PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309220696
Category : Medical
Languages : en
Pages : 468

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Book Description
Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer. Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain. Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.

Breast Cancer Metastasis and Drug Resistance

Breast Cancer Metastasis and Drug Resistance PDF Author: Aamir Ahmad
Publisher: Springer Nature
ISBN: 3030203018
Category : Medical
Languages : en
Pages : 432

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Book Description
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Hormonally Active Agents in the Environment

Hormonally Active Agents in the Environment PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309064198
Category : Science
Languages : en
Pages : 453

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Book Description
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Environment and Breast Cancer

Environment and Breast Cancer PDF Author: Jose Russo
Publisher: Springer Science & Business Media
ISBN: 1441998969
Category : Medical
Languages : en
Pages : 247

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Book Description
Breast cancer is a complex disease caused by multiple environmental and lifestyle factors interacting with genetic susceptibility across the life span. Therefore, environmental factors are of intense interest to both researchers and community members, including women with breast cancer. There is not adequate literature that addresses this issue comprehensively from epidemiological, experimental, and translational research perspective. This book is aiming to fill this gap by gathering chapters from the most recognized experts in the field of breast biology and cancer with special interests in environmental issues.

Multiple Imputation for Nonresponse in Surveys

Multiple Imputation for Nonresponse in Surveys PDF Author: Donald B. Rubin
Publisher: John Wiley & Sons
ISBN: 0470317361
Category : Mathematics
Languages : en
Pages : 258

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Book Description
Demonstrates how nonresponse in sample surveys and censuses can be handled by replacing each missing value with two or more multiple imputations. Clearly illustrates the advantages of modern computing to such handle surveys, and demonstrates the benefit of this statistical technique for researchers who must analyze them. Also presents the background for Bayesian and frequentist theory. After establishing that only standard complete-data methods are needed to analyze a multiply-imputed set, the text evaluates procedures in general circumstances, outlining specific procedures for creating imputations in both the ignorable and nonignorable cases. Examples and exercises reinforce ideas, and the interplay of Bayesian and frequentist ideas presents a unified picture of modern statistics.

Environment and Breast Cancer

Environment and Breast Cancer PDF Author: Jose Russo
Publisher: Springer
ISBN: 9781489993915
Category : Medical
Languages : en
Pages : 0

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Book Description
Breast cancer is a complex disease caused by multiple environmental and lifestyle factors interacting with genetic susceptibility across the life span. Therefore, environmental factors are of intense interest to both researchers and community members, including women with breast cancer. There is not adequate literature that addresses this issue comprehensively from epidemiological, experimental, and translational research perspective. This book is aiming to fill this gap by gathering chapters from the most recognized experts in the field of breast biology and cancer with special interests in environmental issues.