Endogenous and Exogenous Neuroprotection by Neurotrophic Factors in the Mammalian Retina PDF Download
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Author: Daniel Matthew Paskowitz
Publisher:
ISBN:
Category :
Languages : en
Pages : 352
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Book Description
Neurotrophic factors play central roles in the developing and mature nervous system by promoting neuronal survival. The discovery in 1990 that an exogenously supplied neurotrophic factor could slow the progression of photoreceptor loss in an animal model of retinal degeneration has given rise to an active field of research whose ultimate goal is to develop neuroprotective therapy for patients with blinding diseases. At the same time, a growing body of evidence suggests that endogenously expressed neurotrophic factors maintain retinal health and mediate retinal responses to stress throughout life. This thesis investigates both the requirement for retinal expression of neurotrophic factors in a model of endogenous neuroprotection, and the activity of exogenous factors in a clinically relevant new model of retinal injury.
Author: Daniel Matthew Paskowitz
Publisher:
ISBN:
Category :
Languages : en
Pages : 352
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Book Description
Neurotrophic factors play central roles in the developing and mature nervous system by promoting neuronal survival. The discovery in 1990 that an exogenously supplied neurotrophic factor could slow the progression of photoreceptor loss in an animal model of retinal degeneration has given rise to an active field of research whose ultimate goal is to develop neuroprotective therapy for patients with blinding diseases. At the same time, a growing body of evidence suggests that endogenously expressed neurotrophic factors maintain retinal health and mediate retinal responses to stress throughout life. This thesis investigates both the requirement for retinal expression of neurotrophic factors in a model of endogenous neuroprotection, and the activity of exogenous factors in a clinically relevant new model of retinal injury.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 924
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Book Description
Author: Helga Kolb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Giovanna Gambarotta
Publisher: Frontiers Media SA
ISBN: 2889632687
Category :
Languages : en
Pages : 302
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Book Description
Author: Gerd Kempermann
Publisher: Oxford University Press, USA
ISBN: 9780195179712
Category : Language Arts & Disciplines
Languages : en
Pages : 464
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Book Description
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience-the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
Author: Leonard Levin
Publisher: CRC Press
ISBN: 0824756134
Category : Medical
Languages : en
Pages : 336
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Book Description
Ocular neuroprotection is aimed at protecting the death of photoreceptors, retinal ganglion, or other important neurons in cases of disease or trauma. Levin (ophthalmology and neurology, U. of Wisconsin at Madison, US) and Di Polo (pathology and cell biology, U. of Montreal, Canada) present 18 chapt.
Author: James D. Reynolds
Publisher: Springer Science & Business Media
ISBN: 3642120415
Category : Medical
Languages : en
Pages : 459
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Book Description
Pediatric retinal diseases are not simply retinal diseases that occur in children; rather, they are unique disorders that often are not found in adults. This textbook of the pediatric retina offers in-depth guidance on congenital and acquired diseases of the retina in the pediatric population. It is organized according to disease onset and timing, as well as anatomy. All chapters are written by leading authorities in the field from both the pediatric and the retinal perspective. A multidisciplinary approach to the topic is adopted, and critical information is included on disease classification and diagnosis, pathophysiology, genetics, complications, and prognosis. Pediatric Retina will be a useful source of information for pediatric ophthalmologists, retina specialists, and other eye care providers who care for children.
Author: Craig Halberstadt
Publisher: Elsevier
ISBN: 0080469043
Category : Science
Languages : en
Pages : 699
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Book Description
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation
Author: Gary R. Lewin
Publisher: Springer Science & Business Media
ISBN: 3642451063
Category : Medical
Languages : en
Pages : 514
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Book Description
This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
Author: Zlatko Dembic
Publisher: Academic Press
ISBN: 0124200109
Category : Medical
Languages : en
Pages : 323
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Book Description
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
