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Author: M. Ali Aboudzadeh
Publisher: Springer Nature
ISBN: 3030620522
Category : Technology & Engineering
Languages : en
Pages : 473
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Book Description
The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion‐based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production.
Author: M. Ali Aboudzadeh
Publisher: Springer Nature
ISBN: 3030620522
Category : Technology & Engineering
Languages : en
Pages : 473
Get Book Here
Book Description
The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion‐based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production.
Author: Shahin Roohinejad
Publisher: John Wiley & Sons
ISBN: 1119247144
Category : Technology & Engineering
Languages : en
Pages : 288
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Book Description
A comprehensive text that offers a review of the delivery of food active compounds through emulsion-based systems Emulsion-based Systems for Delivery of Food Active Compounds is a comprehensive recourse that reviews the principles of emulsion-based systems formation, examines their characterization and explores their effective application as carriers for delivery of food active ingredients. The text also includes information on emulsion-based systems in regards to digestibility and health and safety challenges for use in food systems. Each chapter reviews specific emulsion-based systems (Pickering, multiple, multilayered, solid lipid nanoparticles, nanostructured lipid carriers and more) and explains their application for delivery of food active compounds used in food systems. In addition, the authors – noted experts in the field – review the biological fate, bioavailability and the health and safety challenges of using emulsion-based systems as carriers for delivery of food active compounds in food systems. This important resource: Offers a comprehensive text that includes detailed coverage of emulsion-based systems for the delivery of food active compounds Presents the most recent development in emulsion-based systems that are among the most widely-used delivery systems developed to control the release of food active compounds Includes a guide for industrial applications for example food and drug delivery is a key concern for the food and pharmaceutical industries Emulsion-based Systems for Delivery of Food Active Compounds is designed for food scientists as well as those working in the food, nutraceutical and pharmaceutical and beverage industries. The text offers a comprehensive review of the essential elements of emulsion-based systems for delivery of food active compounds.
Author: Seid Mahdi Jafari
Publisher: Academic Press
ISBN: 0128118393
Category : Technology & Engineering
Languages : en
Pages : 665
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Book Description
Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods
Author: Yuanjie Pan
Publisher:
ISBN: 9781339542485
Category :
Languages : en
Pages :
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Book Description
Ability of encapsulation systems to improve oxidative stability of the encapsulated bioactives and control the release of these compounds during digestion is critical for shelf-life of products and enhanced bioavailability of the encapsulated bioactives. The objectives of this study were to evaluate: (a) the effect of chemical and physical properties of the core and interface of encapsulation systems in influencing the oxidative stability of the encapsulated compounds, and (b) the influence of interfacial composition on dynamics of the interface during simulated intestinal digestion and the correlation of structural changes in interface with the release of free fatty acids. In this research, design of the interface of the encapsulation systems to improve the oxidative barrier properties includes engineering chemical and physical properties of the interface. Oil-in-water emulsion was selected as a model encapsulation system for encapsulating hydrophobic bioactive compounds. Chemical properties of the interface were engineered using localization of antioxidants at the interface by selecting emulsifiers with antioxidant properties and chemical conjugation of antioxidants to the interfacial layer. Physical properties of the interface were modified using a layer-by-layer coating approach at the emulsion interface. To evaluate the influence of core properties of the encapsulation systems in influencing oxidative stability of bioactives, encapsulation systems were designed using both lipid and protein cores. In the case of lipid core encapsulation systems, oil-in-water emulsion, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were evaluated. In the case of protein core particles, zein protein core particles were synthesized and the oxidative barrier properties of these particles were compared with emulsions. Oxidative barrier properties of the encapsulation systems were simulated by measuring the rate of reaction of peroxyl radicals generated in the aqueous phase with the encapsulated radical sensitive dye in the core. The results of peroxyl radical permeation were compared to the stability of encapsulated model bioactives in encapsulation systems. Structure changes of the interface of encapsulation systems during simulated intestinal digestion were measured using a Fluorescence Resonance Energy Transfer (FRET) based real-time method and these changes were correlated with the release of free fatty acids. Role of biopolymer coatings at the interface in influencing the structure changes of interface during intestinal digestion was evaluated. The results of this research demonstrate the advantage of localization of antioxidant at the interface using emulsifiers with antioxidant properties and localizing a model antioxidant at the interface by chemical conjugation of the antioxidant to the interfacial layer in reducing permeation of radicals and oxidation of a model encapsulated bioactive. However, short chain polymer coatings at the interface of encapsulation systems had limited impact on improving the oxidative stability of the model encapsulated bioactive. Zein colloidal particles had improved oxidative stability against radical induced oxidation compared to oil-in-water emulsions. Neither zein colloidal particles nor oil-in-water emulsions were capable of limiting oxygen induced oxidation. By comparing the oxidative stability of encapsulated bioactives in SLNs and NLCs, the results suggest that the intra-particle distribution of the encapsulated bioactive affected their oxidative stability. Oxidative stability of the encapsulated bioactive improved as the proportion of liquid lipid within particles increased in NLCs. FRET method was effective in measuring the real-time changes in the interface during digestion without separation the encapsulation systems. Results from the FRET measurements were correlated to the release of free fatty acids. The results demonstrate that the disruption of phospholipids at the interface and the displacement from the interface was instantaneous upon addition of bile salts. Moreover, addition of a second layer of polymers at the interface could decrease the extent of interface disruption by bile salts and pancreatic lipase and the release of free fatty acids during intestinal digestion. Overall, the results of this research provide a quantitative framework to engineer the interface and core of encapsulation systems and evaluate their oxidative barrier properties and also enable detailed understanding of real-time dynamics of interface of encapsulation systems during simulated intestinal digestion. This comprehensive approach can enable rational design and engineering of encapsulation systems for extended oxidative stability and controlled release of encapsulated bioactives.
Author: Seid Mahdi Jafari
Publisher: Academic Press
ISBN: 0128097418
Category : Technology & Engineering
Languages : en
Pages : 500
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Book Description
Nanoencapsulation of Food Bioactive Ingredients: Principles and Applications brings different nanoencapsulated food bioactive ingredients, their structure, applications, preparation, formulations and encapsulation methodologies, covering a wide range of compounds and giving detailed examples of the issues faced in their nano-encapsulation. The book addresses findings related to the study of natural food colorants, vitamins, antimicrobial agents, phenolic compounds, antioxidants, flavors, essential oils, fish oil and essential fatty acids, and other related ingredients. As a definitive manual for researchers and industry personnel working, or interested in, various branches of encapsulation for food ingredients and nutraceutical purposes, users will find this a great reference. Explains different categories of nanoencapsulated food ingredients, covering their applications, nanoencapsulation techniques, release mechanisms and characterization methods Addresses findings related to the study of natural food colorants, vitamins, antimicrobial agents, phenolic compounds, antioxidants, flavors and essential oils Provides a deep understanding and potential of nanoencapsulated food ingredients, as well as their novel applications in functional foods and nutraceutical systems
Author: Fabien Salaün
Publisher: BoD – Books on Demand
ISBN: 1838818693
Category : Technology & Engineering
Languages : en
Pages : 142
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Book Description
This book is intended to provide an overview and review of the latest developments in microencapsulation processes and technologies for various fields of applications. The general theme and purpose are to provide the reader with a current and general overview of the existing microencapsulation systems and to emphasize various methods of preparation, characterization, evaluation, and potential applications in various fields such as medicine, food, agricultural, and composites. The book targets readers, including researchers in materials science processing and/or formulation and microencapsulation science, engineers in the area of microcapsule development, and students in colleges and universities.
Author: Per Vilstrup
Publisher: Woodhead Publishing Limited
ISBN:
Category : Food
Languages : en
Pages : 276
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Book Description
CONTENTS Microencapsulation: what it is and its purpose; Microcapsule characterisation: release kinetics/mechanism; Legal aspects; Single core encapsulation -filmcoating; liposomes in the food industry and centrifugal coextrusion encapsulation; Multiple core encapsulation- encapsulation materials; the spray drying of food ingredients; modified spray congealing/spray drying of aqueous dispersions; microencapsulation and alginate; extrusion technology and microencapsulation.
Author: Carlos Bravo-Diaz
Publisher: Springer Nature
ISBN: 303087222X
Category : Technology & Engineering
Languages : en
Pages : 477
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Book Description
This book offers a new physical chemistry perspective on the control of lipid oxidation reactions by antioxidants, and it further explores the application of several oxidation inhibition strategies on food and biological systems. Divided in 3 parts, the book reviews the latest methods to control lipid oxidation, it examines lipid oxidation and inhibition in different food systems, and it finishes with an overview of the biological, health and nutritional effects of lipid oxidation. Chapters from expert contributors cover topics such as the use of magnetic methods to monitor lipid and protein oxidation, the kinetics and mechanisms of lipid oxidation and antioxidant inhibition reactions, interfacial chemistry, oxidative stress and its impact in human health, nutritional, sensory and physiological aspects of lipid oxidation, and new applications of plant and marine antioxidants. While focused on lipid peroxidation in food and biological systems, the chemistry elucidated in this book is applicable also to toxicology, medicine, plant physiology and pathology, and cosmetic industry. The book will therefore appeal to researchers in the lipid oxidation field covering food, biological and medical areas.
Author: Qian Shen
Publisher:
ISBN:
Category : Antioxidants
Languages : en
Pages : 278
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Book Description
"Astaxanthin is an active antioxidant and has beneficial effect on human health. However, its hydrophobic nature and susceptibility to light, heat and oxygen limit its application in most food systems. This study aimed to encapsulate astaxanthin using milk proteins and carbohydrate, in order to improve its stability and application in food systems. Whey protein isolate (WPI) and sodium caseinate (SC) are well known encapsulants and possess antioxidant properties. Soluble corn fibre 70 (SCF70) with DE 20 is believed to exhibit antioxidant activity and to improve encapsulating capacity of protein-based wall systems. They were therefore selected as the wall materials for encapsulation of astaxanthin. The wall solution was prepared from dissolving the emulsifier and carbohydrate containing a total of 20-24 wt% solids in water. The astaxanthin emulsions were prepared by two-stage homogeniser at 80 + 800 bars after passing through the homogeniser 4 times. The emulsion were then converted into powders with 0.33 wt% astaxanthin by spray drying at 160°C inlet air temperature and 70°C outlet air temperature. The properties of the emulsions were evaluated including droplet size, size distribution, zeta potential, and viscosity. The powder produced from spray drying were characterised by chemical and physical tests including water activity, microencapsulation efficiency, surface properties and oxidative stability. The interaction between wall materials was studied using Fourier Transform Infrared Spectroscopy (FTIR) while the bioaccessibility was investigated in an in vitro digestion study. Results show that droplet size of the astaxanthin emulsions was below 200 nm and size distribution appeared to be narrowly distributed. Therefore, particle size would have little effect on the physicochemical properties of spray dried powders. The low viscosity of the parent emulsions probably exhibited little effect on the spray drying process. It was found that the reconstituted emulsion and parent emulsion both had droplet size below 200 nm. This indicates that the astaxanthin emulsions could be stable during spray drying. Scanning electron microscopy reveals that formation of surface dents on some samples caused by particle shrinkage during early drying process. Particle with WPI based wall systems had smoother outer surface than those formulated with SC based wall matrices, suggesting that WPI could be a suitable encapsulating agent in combination with soluble corn fibre 70. Microencapsulation efficiency of the microencapsulated astaxanthin was above 88%, indicating the wall matrices were effective in preventing penetration of the organic solvent into the microcapsule. Storage test was conducted at 45°C and 33% relative humidity, under air and nitrogen environment. The oxidative stability of the astaxanthin microcapsules was determined by measuring peroxide value and p-anisidine value. Results show that surface oil might not be related to the oxidative stability of the microcapsules and other factors might adversely affect the oxidative stability. Changes in the physical state of the amorphous powders due to the difference in water activity between the powders and storage environment might influence the oxidative stability and the astaxanthin content in the microcapsules. Results indicate that wall composition may have little effect on the oxidative stability of the microencapsulated astaxanthin. Astaxanthin content in microcapsules with high oil content decreased slightly faster than in those containing less oil content. Oxidative stability of the microcapsules could be related to the antioxidant activity of raw materials. The FTIR results indicated the possibility of Maillard reaction products formation, which may also influence the oxidative stability of the microcapsules. The in vitro digestion results suggested that the digestivity of the WPI based wall systems might be better than that of the SC based wall systems, as the bioaccessibility of the microcapsule were higher. The presence of dietary fibre (i.e., SCF70) and wall thickness might affect the in vitro digestivity of the microcapsules. Overall, the best formulation showing the best bioaccessibility (71.67%) is the WPI/SCF 70 ratio of 1/0.5 and the wall/core ratio of 2. In summary, this research has shown that microencapsulation of astaxanthin by spray drying technique is capable of producing a more stable microcapsule that has potential application in food system"--Abstract.
Author: E Decker
Publisher: Woodhead Publishing
ISBN: 9780081014578
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Oxidative rancidity is a major cause of food quality deterioration, leading to the formation of undesirable off-flavours as well as unhealthy compounds. Antioxidants are widely employed to inhibit oxidation, and with current consumer concerns about synthetic additives and natural antioxidants are of much interest. The two volumes of Oxidation in foods and beverages and antioxidant applications review food quality deterioration due to oxidation and methods for its control. The second volume reviews problems associated with oxidation and its management in different industry sectors. Part one focuses on animal products, with chapters on the oxidation and protection of red meat, poultry, fish and dairy products. The oxidation of fish oils and foods enriched with omega-3 polyunsaturated fatty acids is also covered. Part two reviews oxidation in plant-based foods and beverages, including edible oils, fruit and vegetables, beer and wine. Oxidation of fried products and emulsion-based foods is also discussed. Final chapters examine encapsulation to inhibit lipid oxidation and antioxidant active packaging and edible films. With its distinguished international team of editors and contributors, the two volumes of Oxidation in foods and beverages and antioxidant applications is standard references for R&D and QA professionals in the food industry, as well as academic researchers interested in food quality.
