Effects of Exercise on Arterial Stiffness, Heart Rate Variability and Inflammatory Marker Hs-CRP in Type 2 Diabetes PDF Download
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Author: Anka Brozic
Publisher:
ISBN: 9780494389188
Category :
Languages : en
Pages : 206
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Book Description
In patients with type 2 diabetes (DM2) arterial stiffness, heart rate variability (HRV), high sensitivity C-reactive protein (hs-CRP) and hyperaemic calf blood flow were measured before and after 12 weeks of combined aerobic and resistance exercise training. Arterial stiffness and HRV were also measured after 20 minutes of moderate, aerobic exercise pre and post exercise training. A single acute bout of aerobic exercise results in significantly elevated central arterial stiffness both before and after 12 weeks of training whereas AAI is reduced prior to training only. After 12 weeks of training, significant improvements were found in: C-F PWV (p=0.026); augmentation index (p= 0.005); peak oxygen uptake (p=.002) fasting plasma glucose (p=0.041), abdominal circumference (p=0.001), BMI (p=0.004) and body fat (p=0.032). Improvements in arterial stiffness were not associated with any change in anthropometric measurements, aerobic fitness, hs-CRP or indices of heart rate variability.
Author: Anka Brozic
Publisher:
ISBN: 9780494389188
Category :
Languages : en
Pages : 206
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Book Description
In patients with type 2 diabetes (DM2) arterial stiffness, heart rate variability (HRV), high sensitivity C-reactive protein (hs-CRP) and hyperaemic calf blood flow were measured before and after 12 weeks of combined aerobic and resistance exercise training. Arterial stiffness and HRV were also measured after 20 minutes of moderate, aerobic exercise pre and post exercise training. A single acute bout of aerobic exercise results in significantly elevated central arterial stiffness both before and after 12 weeks of training whereas AAI is reduced prior to training only. After 12 weeks of training, significant improvements were found in: C-F PWV (p=0.026); augmentation index (p= 0.005); peak oxygen uptake (p=.002) fasting plasma glucose (p=0.041), abdominal circumference (p=0.001), BMI (p=0.004) and body fat (p=0.032). Improvements in arterial stiffness were not associated with any change in anthropometric measurements, aerobic fitness, hs-CRP or indices of heart rate variability.
Author: Joshua McGee
Publisher:
ISBN:
Category :
Languages : en
Pages : 128
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Book Description
Obesity is a major risk factor for cardiovascular disease (CVD), CVD mortality, and type 2 diabetes. Arterial stiffness and autonomic dysfunction are independent predictors of CVD and type 2 diabetes. Moreover, African Americans (AA) have a disproportionate prevalence of elevated arterial stiffness compared to Caucasians. Obese individuals have a greater prevalence of diminished autonomic nervous system activity compared to lean individuals. Despite evidence of aerobic exercise training benefiting arterial stiffness and autonomic dysfunction in the general population, optimal intensity and volume for AAs and obese individuals remain unclear. The purpose of this dissertation was to determine whether high-intensity aerobic exercise training improved arterial stiffness and aortic compliance to a greater degree than moderate intensity in obese AAs (study 1), if clinically significant weight loss from a combined hypocaloric diet and aerobic exercise intervention increases heart rate variability (HRV) in obese adults and to evaluate the impact of aerobic exercise volume on HRV during weight maintenance (study 2). Arterial stiffness or aortic compliance did not improve in response to 24 weeks of moderate- or high-intensity, supervised aerobic exercise training at a volume consistent with public health guidelines. However, both groups significantly increased cardiorespiratory fitness compared to the control group. In addition, we observed an inverse relationship between changes in cardiorespiratory fitness and aortic compliance. The results from this study suggest AAs may require greater volumes of weekly aerobic exercise than recommended for the general population to improve arterial stiffness. The 10-week, combined intervention improved major HRV indices of parasympathetic activity. The changes in parasympathetic activity were inversely associated with fasting insulin concentrations. Both groups retained all HRV benefits over the 18-week maintenance phase. The results from this study suggest weight loss via energy restriction and exercise alter autonomic function, leading to improved sympathovagal balance in obese adults, also exercise volumes consistent with physical activity guidelines maintains improvements in autonomic function from weight loss. Collectively, the results of this dissertation provide valuable public health insight for health professionals prescribing aerobic exercise to improve predictors of CVD and type 2 diabetes, specifically arterial stiffness, aortic compliance, and autonomic dysfunction in at-risk, obese adults.
Author: Linda S. Pescatello
Publisher: Springer
ISBN: 3319170767
Category : Medical
Languages : en
Pages : 347
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Book Description
As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as 24-hour ambulatory blood pressure profile and oxidative stress. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. Lastly, the book will end with a chapter on the interactive effects of genes and exercise on blood pressure. Chapters are grouped by physiological system or mechanism. The text begins with two overview chapters; one on the general effects of aerobic exercise training and the second on the general effects of resistance exercise training on blood pressure. Each chapter begins with a bulleted list of key points. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.
Author: Chetan Trivedy
Publisher: CRC Press
ISBN: 0340985011
Category : Medical
Languages : en
Pages : 771
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Book Description
This book is a dedicated resource for those sitting the Part A of the MCEM (Membership of the College of Emergency Medicine) examination. It forms an essential revision guide for emergency trainees who need to acquire a broad understanding of the basic sciences, which underpin their approach to clinical problems in the emergency department. Common clinical scenarios are used to highlight the essential underlying basic science principles, providing a link between clinical management and a knowledge of the underlying anatomical, physiological, pathological and biochemical processes. Multiple choice questions with reasoned answers are used to confirm the candidates understanding and for self testing. Unlike other recent revision books which provide MCQ questions with extended answers, this book uses clinical cases linked to the most recent basic science aspects of the CEM syllabus to provide a book that not only serves as a useful revision resource for the Part A component of the MCEM examination, but also a unique way of understanding the processes underlying common clinical cases seen every day in the emergency department. This book is essential for trainees sitting the Part A of the MCEM exam and for clinicians and medical students who need to refresh their knowledge of basic sciences relevant to the management of clinical emergencies.
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330
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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author: Peter Kokkinos
Publisher: Jones & Bartlett Learning
ISBN: 0763756121
Category : Health & Fitness
Languages : en
Pages : 434
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Book Description
Health Sciences & Professions
Author: Filippo Crea
Publisher: Springer Science & Business Media
ISBN: 8847053676
Category : Medical
Languages : en
Pages : 263
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Book Description
In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Author: Gerald F. Fletcher
Publisher: Wiley-Blackwell
ISBN: 9780879935597
Category : Medical
Languages : en
Pages : 446
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Book Description
The third edition of this popular and successful text has been fully revised and updated to take account of recent advances in the field, particularly in the physiology and pathophysiology of many disease processes. The text retains the original format of relevant physiology, test selection and test interpretation by case example. Essential aspects of paediatric chemical pathology, inborn errors of metabolism, reproductive endocrinology, tumours and toxicology are now included. As chemical pathology is receiving specific attention in medical courses, this text has been adapted to present this information in an understandable form, making it suitable for medical undergraduates and for medical and science postgraduates studying for exams of Colleges of Pathology and professional associations."
Author: Waliza Ansar
Publisher: Springer
ISBN: 8132226801
Category : Medical
Languages : en
Pages : 324
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Book Description
This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.
Author: Victor F. Froelicher
Publisher: Saunders
ISBN: 9780721684505
Category : Exercise tests
Languages : en
Pages : 0
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Book Description
Here's authoritative, step-by-step guidance on performing a full range of cardiac exercise tests. The New Edition of this respected resource has been thoroughly revised and updated to reflect the most current techniques and latest clinical data. Provides comprehensive coverage of cardiopulmonary physiology and methodology, nuclear testing, and echocardiography helps readers avoid complications by detailing the most dangerous testing circumstances and citing instances when cool down walks, pre-test physical exams or echocardiograms are advisable Discusses the proper ways to adjust treadmill protocols, calculate target heart rates, position the patient post-exercise, report exercise capacity and include predicative equations as part of the treadmill report Provides tabular summaries of major studies, accompanied by expert commentary Follows the new evidence-based ACC/AHA guideline format, class I, II, or III Reflects the latest guidelines on exercise testing from the Agency for Health Care Policy and Research Practice Guidelines on Cardiac Rehabilitation, the Surgeon Generals Report on Physical Activity and Health, the new editions of the AACVPR, and the ASCM Guidelines on Exercise Testing and Prescription
