Dynamical Biostatistical Models PDF Download
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Author: Daniel Commenges
Publisher: CRC Press
ISBN: 1498729681
Category : Mathematics
Languages : en
Pages : 391
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Book Description
Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be ap
Author: Daniel Commenges
Publisher: CRC Press
ISBN: 1498729681
Category : Mathematics
Languages : en
Pages : 391
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Book Description
Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be ap
Author: Albert Vexler
Publisher: CRC Press
ISBN: 1315353016
Category : Mathematics
Languages : en
Pages : 622
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Book Description
Statistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments. The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method, with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept, providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods for constructing correct and powerful statistical decision-making processes to be adapted for complex statistical applications. With techniques spanning robust statistical methods to more computationally intensive approaches, this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies, including clinical trials. Theoretical statisticians, medical researchers, and other practitioners in epidemiology and clinical research will appreciate the book’s novel theoretical and applied results. The book is also suitable for graduate students in biostatistics, epidemiology, health-related sciences, and areas pertaining to formal decision-making mechanisms.
Author: Alex Bottle
Publisher: CRC Press
ISBN: 1315355469
Category : Mathematics
Languages : en
Pages : 184
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Book Description
Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.
Author: Iftekhar Khan
Publisher: CRC Press
ISBN: 1466505486
Category : Mathematics
Languages : en
Pages : 332
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Book Description
Economic evaluation has become an essential component of clinical trial design to show that new treatments and technologies offer value to payers in various healthcare systems. Although many books exist that address the theoretical or practical aspects of cost-effectiveness analysis, this book differentiates itself from the competition by detailing
Author: Scott Evans
Publisher: CRC Press
ISBN: 1498767109
Category : Mathematics
Languages : en
Pages : 352
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Book Description
Fundamental Concepts for New Clinical Trialists describes the core scientific concepts of designing, data monitoring, analyzing, and reporting clinical trials as well as the practical aspects of trials not typically discussed in statistical methodology textbooks. The first section of the book provides background information about clinical trials. I
Author: Ying Yuan
Publisher: CRC Press
ISBN: 1315354225
Category : Mathematics
Languages : en
Pages : 238
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Book Description
Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
Author: Kerry B. Barker
Publisher: CRC Press
ISBN: 1315355906
Category : Mathematics
Languages : en
Pages : 226
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Book Description
Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various potential drug development strategies, the design and analysis of pharmacokinetics (PK) studies, and the design and analysis of efficacy studies.
Author: Benoit Liquet
Publisher: CRC Press
ISBN: 1040116884
Category : Computers
Languages : en
Pages : 415
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Book Description
Mathematical Engineering of Deep Learning provides a complete and concise overview of deep learning using the language of mathematics. The book provides a self-contained background on machine learning and optimization algorithms and progresses through the key ideas of deep learning. These ideas and architectures include deep neural networks, convolutional models, recurrent models, long/short-term memory, the attention mechanism, transformers, variational auto-encoders, diffusion models, generative adversarial networks, reinforcement learning, and graph neural networks. Concepts are presented using simple mathematical equations together with a concise description of relevant tricks of the trade. The content is the foundation for state-of-the-art artificial intelligence applications, involving images, sound, large language models, and other domains. The focus is on the basic mathematical description of algorithms and methods and does not require computer programming. The presentation is also agnostic to neuroscientific relationships, historical perspectives, and theoretical research. The benefit of such a concise approach is that a mathematically equipped reader can quickly grasp the essence of deep learning. Key Features: A perfect summary of deep learning not tied to any computer language, or computational framework. An ideal handbook of deep learning for readers that feel comfortable with mathematical notation. An up-to-date description of the most influential deep learning ideas that have made an impact on vision, sound, natural language understanding, and scientific domains. The exposition is not tied to the historical development of the field or to neuroscience, allowing the reader to quickly grasp the essentials. Deep learning is easily described through the language of mathematics at a level accessible to many professionals. Readers from fields such as engineering, statistics, physics, pure mathematics, econometrics, operations research, quantitative management, quantitative biology, applied machine learning, or applied deep learning will quickly gain insights into the key mathematical engineering components of the field.
Author: Adetayo Kasim
Publisher: CRC Press
ISBN: 1315356392
Category : Mathematics
Languages : en
Pages : 433
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Book Description
Proven Methods for Big Data Analysis As big data has become standard in many application areas, challenges have arisen related to methodology and software development, including how to discover meaningful patterns in the vast amounts of data. Addressing these problems, Applied Biclustering Methods for Big and High-Dimensional Data Using R shows how to apply biclustering methods to find local patterns in a big data matrix. The book presents an overview of data analysis using biclustering methods from a practical point of view. Real case studies in drug discovery, genetics, marketing research, biology, toxicity, and sports illustrate the use of several biclustering methods. References to technical details of the methods are provided for readers who wish to investigate the full theoretical background. All the methods are accompanied with R examples that show how to conduct the analyses. The examples, software, and other materials are available on a supplementary website.
Author: Constantine Gatsonis
Publisher: CRC Press
ISBN: 1351659456
Category : Mathematics
Languages : en
Pages : 634
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Book Description
Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies—experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections—causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.
